磷酰胺

Results: a In the negative control group, spontaneous chromosome aberration and micronucleus rated the mice's were very low; in the positive control group, chromosome aberration and micronucleus rate of the mice's were highest. b Before cyclophosphamide intoxation, when the four kinds of vegetables and hilts juice were preventively irrigated into the mice's stomachs respectively, the chromosome aberration and micronucleus rate in the negative control group were lower than these in the positive control group (P.05); but after intoxation, when the four kinds of vegetables and fruits juice were therapeutically irrigated into the mice's stomachs respectively, the chromosome aberration and micronucleus rate were similar with the result above mentioned . c Acing the four kinds of vegetables and fruits, sea-buckthorn lad the best preventive and curative effects.

结果：a在阴性对照组中，小鼠自发的染色体畸变率和微核率极低；在阳性对照组中，小鼠染色体畸变率和微核率最高。b在环磷酰胺染毒之前，分别将4种蔬菜水果汁给小鼠进行预防性灌胃，其染色体畸变率和微核率均比阳性对照组低(P.05)；在染毒之后，分别将4种蔬菜水果给小鼠治疗性灌胃，其结果与上述实验结果相似。c在4种蔬菜水果中，以沙棘的预防和治疗效果为最好。

Of them 25 cases of oral cancer (G1-2) were randomly divided into trail and control group . The remained 11 cases of nasopharyngeal and maxillary sinus cancer (NPC-MSC, mainly G3-4) were attributed to a third group (1st course: sBRM, then 2nd course: IAC). The order of drug-use of sBRM is: pre-immunomodulation of the reactivity of patient low-dose CTX and PolyI∶C, then in- juring tumor and thereby modulation of its immunogeneity (DDP-PYM regimen , thereafter, reaction enhancement modu- lation [low-dose rhuIL-2, Cimetidine and Indomethacin ] . All drugs, except for CTX, PolyI∶C and Indo, were fractionally delivered in a manner of continously infution in 8-10 hours via a retaining intra-external carotid artery catheter CAVAFIX 335 SPLITTOCAN G14, B.

将其中25例晚期口腔高、中分化鳞癌病人随机分为实验治疗（12例）和对照治疗（13例）两组，实验组采用sBRM疗法，具体用药为：先用小剂量环磷酰胺和聚肌胞对机体反应性作预调变，然后用低剂量DDP-PYM化疗杀伤&致创&癌细胞，使其免疫原性增强并借之诱导肿瘤浸润淋巴细胞，化疗结束后续用小剂量rhuIL-2激活和扩增TIL，特别是其中的T细胞，并借助小剂量西咪替丁、消炎痛调节机体以原发灶为中心的癌受创相关反应。

Methods （1）the experiment in body:the knubbly cell S 180 and the cwer cancer knubbly cell H 22 was inoculated in left and front axillary of rats,which were taken medicine in stomach next day.Saline,cyclophosphamide and different dose Fufangshuizhiwan were used re-spectively in negative comparison group,electropositive comparison group and Chinese medicine group for12days.

（1）体内抑瘤实验：取小白鼠左前腋下接种S 180 瘤种和H 22 肝癌瘤种，次日开始灌胃给药，阴性对照组给予生理盐水，阳性对照组给予环磷酰胺，中药组分别给予大、小剂量的复方水蛭丸，连续用药12天。

The extract of propolis could relieve leucocytopenia and thrombocytopenia caused by chemotherapeuant clearly.

蜂胶提取物与环磷酰胺合用有协同抗肿瘤作用，并能减轻肿瘤化疗药物的毒副作用。

Methods Models of leucocytopenia induced by irradiation were prepared by 60Coγ-ray and by cyclophosphamide injection. The shengbaiyin was administrated orally. The white blood cell counts, reticulocyte count, the number of nucleated bone marrow cells,T cell transformation indices, activity of tunmor necrosis factor and interleukin-6(IL-6) in blood of leukopenia mice on the 5th, 10th, 15st day after chymisty therapeutics were checked.

用60Coγ照射和注射给予环磷酰胺的方法形成骨髓抑制和免疫低下小鼠模型，中药生白饮合剂给予口服，以外周血白细胞、骨髓有核细胞、淋转指数以及细胞肿瘤因子、白细胞介素－6(IL-6)活性为观察指标。

Aim To study the immunomodulatory activity of total flavonoids of Litsea Coreana Leveille on cyclophosphamide-induced immunosuppressive mice.

目的 研究豹皮樟总黄酮(litsea coteana total flavone， LCTF)对环磷酰胺(cyclophosphamide， Cy)诱导的免疫低下小鼠免疫功能的影响。

Methods 36 patients with mastocarcinoma Ⅲ are given CAP regimen (Cyclophosphamide、 Adriamycin, arid Cisplatin) for one cycle-of 21 - 28 days,after preoperation chemotherapy 2-3 cycles,evaluation of effect is conducted.

在我院收治的36例Ⅲ期乳腺癌患者术前应用环磷酰胺联合阿霉素和顺铂方案21～28天为一周期，术前化疗2～3周期后评价疗效。

Objective To detect the effect of cyclophosphamide administered by means of metronomic chemotherapy combined maximum tolerated dose chemotherapy on the angiogenesis, carcinogenesis and metastasis of Lewis lung cancer on C57BL/6 mouse model.

目的 探讨环磷酰胺节律化疗联合最大耐受量化疗对小鼠Lewis肺癌肿瘤生长、血管生成和远处转移的影响。

Objective To detect the effect of cyclophosphamide administered by means of metronomic chemotherapy combined maximum tolerated dose chemotherapy on the angiogenesis, carcinogenesis and metastasis of Lewis lung cancer on C57BL/6 mouse model. Method The mice were randomly divided into four groups:（1）metronomic chemotherapy group,（2）MTD group,（3）combination group（metronomic chemotherapy combined MTD group）,（4）control group.

目的 探讨环磷酰胺节律化疗联合最耐受量化疗对小鼠Lewis 肺癌肿瘤生长、血管生成和远处转移的影响方法荷瘤小鼠随机分4组：分别（1）CTX节律化疗组；（2）MTD组；（3）联合组（CTX节律化疗联合MTD化疗）；（4）对照组。

Methods:One case with relapse、refractory and metastasis primary hepatocarcinoma was treated with metronomic therapy regimen:Cyclophosphamide 50mg qd,Xiloda 1000mg bid and Celecoxib 200mg bid, and observed for 4 months.

采用小剂量环磷酰胺50mg每日一次，塞来昔布200mg每日二次，希罗达1000mg每日二次。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。