磷酰胺

Methods S180 and H22 mice were divided into solanine (37.50、18.75, and 9.37mg/kg) groups, negative control group and cytoxan (30mg/kg) group, whom were given drugs by sc.

将S180和H22荷瘤小鼠分为龙葵碱37.50、18.75、9.37mg/kg组、阴性对照组和环磷酰胺(30mg/kg)组，各组sc给药。

MATERIAL AND METHODS: The micronucleus test of mouse bone marrow cell and the sperm abnormality test in rats were used in this study.

材料与方法：采用骨髓嗜多染红细胞微核测试法和精子畸形法评价HY拮抗环磷酰胺所致的遗传物质的损伤作用。

The results suggest that CP might have reproductive damage effect to sperm and testicular germ cell in mice.

小鼠腹腔注射环磷酰胺对雄性小鼠生殖细胞有损害作用。

Cyclophosphamide may causes immunosuppression through the induction of apoposis of thymocyte.

环磷酰胺的免疫抑制作用可能是通过诱导免疫细胞凋亡而产生的。

Methods: Mice bearing in vivo transplanted tumor-H22 hepatic carcinoma were used to evaluate the drug"s activity of anti-tumor and GAPSGF"s efficacy enhancing effect by calculating the ratio of antitumor and q. HE dyeing was applied to observe the tumor"s morphological changes after the anti - tumor drug. It is observed the change of theperipheral white blood cells in serum and the body weight to analyze the GAPSGF"s toxicity reducing effect on the anti - tumor drug-Cytoxan. Applying ELISA method to observe the change of IL-2 in serum ,Applying carbon clearance method to test the function of uninuclear phagocyte,took the weight of the spleen and thoracic gland, analyzed the mechanism — efficacy enhancing and toxicity reducing of GAPSGF.

构建体内动物移植性H_(22)肝癌模型，通过计算抑瘤率与q值来分析药物的体内抗肿瘤活性，判断树舌多糖GF注射液的增效作用；采用瘤组织常规HE染色观察药物作用下的肿瘤细胞形态变化；观察外周血WBC数和体重改变来分析树舌多糖GF注射液对环磷酰胺抗肿瘤的减毒作用；采用ELISA法测定血清IL-2、小鼠碳粒廓清法测定单核吞噬细胞功能、取胸腺与脾脏称重测定脏器指数等以分析树舌多糖GF注射液增效减毒的作用机制。

In this paper, we have studied the effect of medicinal vesiculation on the hematopoietic function and its mechanism in mice treated by Cyclophosphamide.

本实验通过环磷酰胺小鼠模型，观察了天灸对化疗小鼠的造血功能和腹腔巨噬细胞分泌粒细胞－巨噬细胞集落刺激因子能力的影响。

The animals were divided into 4 groups: Control group, CsA group, Cyp group and CyP+CsA group.

动物随机分4组：对照组、环孢素A组、环磷酰胺组和CsA+CyP组。

However, alkylating agents, such as cyclophosphamide, and the topoisomerase II inhibitors, doxorubicin and epirubicin, are associated with two types of cytogenetically distinct leukemias after adjuvant chemotherapy.

然而，烷化剂如环磷酰胺、拓扑异构酶II抑制剂、阿霉素、表阿霉素都与辅助化疗后的两种细胞遗传学不同的白血病的发生相关。

TFC could remarkably inhibit the ear edema induced by dimethylbenzene in mice at the dose of 125,250,500mg.kg~(-1), the swelling of rats hind paws induced by carrageenan and primary inflammatory reaction in AA rats at the dose of 84,168,336 mg.kg~(-1) and reduce the weight of granuloma induced by cotton in rats at the dose of 84,168,336mg.kg~(-1), respectively.

TFC的免疫调节作用体外研究发现，TFC0.005，0.05，0.5，5，50 mg·L~(-1可明显提高环磷酰胺(cyclophosphamid，Cy)诱导免疫功能低下小鼠的脾淋巴细胞增殖反应，而对正常小鼠的脾淋巴细胞增殖无明显作用。

Results: the results showed that extracts of Artemsia dracunculus L. at the dose of 7.5%,3.75%,1.875% 20 ml/kg.w, can cause a signficant increase of WBC (P.05), thymus index, spleen index,(P.05) phagocytic rate and phagocytic index of phagocyte,(P.05) the transformation rate of the spleen lymphocytes,(P.05) and the serum IL-2(P.05),serum hemolysin concentration 50%( P.05)in immunodepressed mice. Conclusions: extracts oil from Artemsia dracunculus L. can significantly enhance the non-specific, cell-mediated and humoral immunological function in immunodepressed mice.

结果：与模型组比较，椒蒿挥发油各组均能升高小鼠外周血白细胞数(P＜0.05)；均能升高胸腺指数(P＜0.05)、脾指数(P＜0.05)；均能提高免疫受抑小鼠腹腔巨噬细胞的吞噬率，吞噬指数(P＜0.05)；均能升高脾淋巴细胞转化率(P＜0.05)；椒蒿挥发油各组血清IL-2值明显高于环磷酰胺对照组(P＜0.05)；椒蒿挥发油各组均可升高小鼠的血清半数溶血值(P＜0.05)。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。