磷酰胺

Objective To determine the risk of sustained amenorrhea in premenopausal women with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy.

环磷酰胺是临床最常应用的烷化剂，在对由免疫介导的风湿病、肾病、神经系统疾病及血液病等疾病的治疗中，疗效肯定。

Purpose To investigate the protective effect of anthraquinone glycosides from coffee senna on immunosuppressive mice induced by cyclophosphamide.

目的 探讨望江南蒽醌苷对环磷酰胺造成的免疫低下小鼠的保护作用。

Results: 32 patients with PNS suffered from acute oliguria or anuria,acute deterioration of renal function and rising of serum BUN and SCr, excluding secondly glomerular disease and acute tubular necrosis?

结果 ：原发性肾病综合征在病情中突然发生少尿或无尿，肾功能急骤恶化，血尿素氮及肌酐上升，排除继发性肾小球疾病及其他原因引起的急性肾小管坏死、急性间质性肾炎和双肾静脉主干血栓形成，经甲基强的松龙和环磷酰胺或吗替麦考酚酯及标准疗程泼尼松、血液透析等对症治疗，32例患者肾功能均改善。

Objective: Study the anti-tumor effects of asiatic acid combined with chemotherapeutics cyclophosphamide or 5-fluorouracil (5-Fu).

目的：研究积雪草酸(asiatic acid， AA)与化疗药物环磷酰胺，5-氟尿嘧啶(5-Fu)联用的抗肿瘤作用。

Methods The bone marrow cells of pure Kumming species of mice were used as experimental material in which the micronucleusand sister chromatid exchanges induced by cyclophosphamide were used as an index.

方法以昆明纯种小鼠的骨髓细胞为实验材料，用公认的诱变剂环磷酰胺诱发的微核率和姐妹染色单体互换频率为指标，研究EGCG对CP诱导小鼠骨髓细胞MN和SCE的影响。

Methods: The expression of mutated P53 gene in human lymphocytes was investigated using flow cytometry.And the micronucleus and sister chromatid exchange tests were studied in vitro.

以正常人外周血淋巴细胞为材料，用流式细胞仪检测环磷酰胺对突变型P53基因表达的影响，同时以微核及姐妹染色单体互换为指标，进行致突变研究。

All of patients were treated by local cycloplegic, systemic treatment with glucocorticoid and cytoxan. The followed-up period was 1 year or more.

所有患者均采用睫状肌麻痹剂以及全身联合应用糖皮质激素和环磷酰胺治疗，随访至少1年以上。

ResultsThe major clinical features are shown as follow: polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes, bone lesion and anemia.50% patients are benefit from the treatment of prednisone and cyclophosphamide.

结果主要临床特征：多发性周围神经病、脏器肿大，内分泌改变，单克隆浆细胞异常，皮肤改变，骨破坏，水肿是POEMS的主要表现。予强的松联合环磷酰胺治疗，有效率50%。

Methods The leukopenia animal model were duplicated with cyclophosphamide by ear vein injection in rabbits.Acupuncture on the rabbits and measure the leukocyte count and classification of peripheral blood every day.On the last day,anesthetized the rabbits,open the abdominal cavity,cut a piece of spleen tissue,and observed the diameter of splenic sinusoid basal lamina eyehole under microscope.

通过家兔静脉注射环磷酰胺复制白细胞减少症模型，采用电针治疗，每天分别于耳缘静脉采血进行外周血白细胞计数和分类，观察血象变化，并于处死前麻醉动物，开腹取脾组织电镜下观测脾血窦基膜小孔口径大小。

The cyclophosphamide group(n=15) was treated with CTX 0.81.0 g/1.73 m2 body surface area infused intravenously once a month for 68 months.

环磷酰胺（CTX冲击组：15例患者采用CTX 0.8～1.0 g/1.73 m2静滴，每月1次，连续6～8个月。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。