磷酰胺

Embryos were explanted and cultured 4 hours after CP administration. On d 10.5, culture was terminated and embryos were examined for yolk sac diameter, head length and crown-rump length and teratogenic effects of CP.

本文应用小鼠全胚胎培养技术，通过妊娠d 8分别ip 5，10，15和20 mg.kg-1环磷酰胺，研究了该药对器官原基形成期胚胎的致畸作用，并对其致畸机理作了初步探索。

The immunodulatory effects were measured by clearance rate K of charcoal particles, phagocytic index a, thymus and spleen index, ear swelling degree, HC50 value and so on.

方法环磷酰胺诱导小鼠免疫功能低下，予金橘黄酮，观察小鼠碳粒廓清指数K、吞噬指数a、胸腺和脾脏指数、耳肿胀度、血清溶血值（HC50）等指标的变化。

The extracts from evening primrose flower could significantly enhance the cellular immune function in immunosuppressed mice. Effects of ethylacetate extract was better than those of water extract.

月见草花乙酸乙酯提取物和水提取物均可明显增强环磷酰胺免疫抑制小鼠的细胞免疫功能，其中乙酸乙酯提取物的作用优于水提取物。

Methods The immuno-suppressive mice models were induced by intraperitoneal injection of cyclophosphamide (50mg/kg). T cell Proliferation response to ConA, the level of TNF-α and IFN-γ were determined after administering evening primrose flower extracts in high, medium and low-dose.

小鼠腹腔注射环磷酰胺(Cyclophosphamide， Cy)50mg/kg建立免疫抑制模型，然后将月见草花两种提取物分别以高、中、低三个剂量（低剂量437.5mg/kg、中剂量875mg/kg和高剂量1750mg/kg）每天1次灌胃，观察对小鼠脾脏T淋巴细胞增殖能力、肿瘤坏死因子－α(Tumor Necrosis Factorα， TNF-α)和干扰素－γ(Interferonγ， IFN-γ)分泌水平的影响。

Routine treatment group(n=28) received adriamycin 40 mg/m~2;vincristine 2 mg.

两组环磷酰胺用量为750 mg/m2，强的松100 mg口服，第1~5天；21天为1周期，共计4周期。

However, the cytotox-ic dugs cant selectively kill the cancer cells without any side -effects, the decrease of peripheral blood WBC for myleosuppression caused by cytotoxic dugs contribute to the limitation of regular chemotherapy. Evidence was provided that cisplatin and cyclophosphamide used for ovarian cancer caused apoptosis in several in vivo tumors. For the reasons above, in our study, we detected the apoptosis of total peripheral blood WBC in patients with ovarian cancers before and after chemotherapy.

然而，由于化疗药物的非选择性组织杀伤引起的骨髓抑制而导致的末梢血白细胞减少，已经成为限制化疗剂量和按期进行规范性化疗的重要障碍，研究已证实卵巢癌的常规化疗方案中的顺铂及环磷酰胺能在多种肿瘤组织中诱导凋亡。

In addition to the common effect of supplementing qi, YiQiYangYin Fang has unique clinical application in exercise-induced fatigue disease because of its function of reinforcing yin; YiQiBuShen Fang is used for treating senescence diseases by reason of its function of invigorating kidney.

本课题以中医药理论为指导，依据益气养阴方和益气补肾方的功效与应用，结合目前运动性疲劳和衰老的产生机制等方面的研究进展，采用现代药理学研究方法，观察益气养阴方和益气补肾方对环磷酰胺致小鼠免疫抑制的抵抗作用及对小鼠常压耐缺氧和断头后张口喘气时间的抗应激能力，同时分别采用运动性疲劳大鼠模型和自然衰老大鼠模型进一步探讨益气养阴方抗运动性疲劳机制及益气补肾方抗衰老机制。

The percentage of hemizygous LOH in CP-induced mutants (50%) was 2.4 times than that of the control (20.7%).

环磷酰胺诱导产生半合子LOH的比例(50%)是对照(20.7%)的2.4倍。

MethodsPolyprenols separated and purified from ginkgobiloba L were administered alone and in combination with 5 Fu,CTX and PDD,and in contrast with 5 Fu,CTX and PDD alone,the experiments were carried out on mouse transplanted Heps and EC.

方法从银杏叶中分离纯化聚戊烯醇，分别与氟脲嘧啶(5 Fu)、环磷酰胺和顺铂联合应用，对移植性Heps和EC荷瘤小鼠进行抑瘤实验，并与 5 Fu、CTX和PDD单独用药比较。

METHODS: 1200 rheumatologists and internists were asked to provide medical files for patients with anti-TNF agents given as a second-line treatment for active SRV refractory to cyclophosphamide and glucocorticoids.

1200名风湿病专家和内科医生提供抗TNF制剂治疗对环磷酰胺和激素疗效差的系统性类风湿血管炎患者的医学资料。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。