磷脂

Mobility of membrane phospholipid and receptors: membrane phospholipid was labeled with the NBD-C〓-HPC and the mobility was measured with FRAP technique, the results showed that the membrane phospholipid mobility gradually deceased with the time of ligand stimulation.

1膜磷脂和受体流动性：利用NBD-C〓-HPC荧光标记细胞膜磷脂和荧光漂白后恢复技术测量膜磷脂流动性，结果显示膜磷脂流动性随配体刺激时间增加而逐渐下降。

Membrane affinity quantified by IAM and liposome/buffer systems was a more efficient predicator of α values than hydrophobicity from n-octanol/buffer system. Consequently, not only hydrophobic force but also attractive polar extra-interactions involved in the binding to IAM and liposomal membranes but not in an n-octanol phase, ascribed to the binding process within AM. The binding to ordered lipid membrane in the larger part determined drugs'binding to AM intracellular compositions, and the ordered phospholipid plasma membrane was a potential site for drugs'binding in AM.

脂质体／水系统和磷脂膜色谱所测定的膜亲和性比正辛醇／水系统的疏水性更好的预测巨噬细胞内药物的α值，因此包含在磷脂膜色谱中但并不体现在正辛醇／水系统中药物与磷脂膜之间的额外吸引性极性作用力对药物在细胞内结合有着重要贡献；药物与有序磷脂膜的结合在很大程度上决定着药物与巨噬细胞内成分的结合，有序磷脂分子膜可能是巨噬细胞内部潜在的结合部位。

Sphingomyelin,phosphatidylcholine,phosphstidylethsnolamine,and cardiolipinare observed in model rats and treatment rats.

观察并对比了两种模型大鼠和相应治疗组的神经鞘磷脂、磷脂酰胆碱、磷脂酰乙醇胺和磷脂酰甘油的含量变化。

Changes of lipid components in cellular membranes of the aging mice, including phosphalipids , cholesterol , phosphatidyl choline , phosphatidyl ethanolamide , sphingomyelin , as well as aging index of cellular membrane-SM/PC and Ch/PL.

对老龄小鼠大脑细胞膜脂质构成变化的影响，包括总磷脂、胆固醇、磷脂酰胆碱、磷脂酰乙醇胺、鞘磷脂及细胞膜老化指数SM／PC、Ch／PL的变化；3。

Methods: Lecithin and the sucrose ester-phospholipids liposome were prepared using the ethyl ether injection method by mixing sucrose ester with lecithin, sphingomyelin and cholesterol according to different lipids ratio.

按不同比例将乙酸异丁酸蔗糖酯与卵磷脂、鞘磷脂和胆固醇混合，溶于乙醚中，然后注入pH7.2的PBS缓冲液中，制成卵磷脂脂质体及蔗糖酯－卵磷脂脂质体。

Primary culture of type II alveolar epithelial cells was performed using IgG panning technique. The experiment was divided into groups as VEGF, Dexamethasone, VEGF plus dexamethasone and a control, to determine total phospholipids, phosphatidylcholine, phosphatidyl glycerol and sphingomyelin.

方法孕19天Wistar大鼠剖腹取胎鼠，原代培养肺泡Ⅱ型细胞，分成VEGF组、地塞米松组、VEGF加地塞米松组和对照组进行试验，测定肺表面活性物质总磷脂、磷脂酰胆碱、磷脂酰甘油、鞘磷脂含量。

Furthermore, taurine-treated microsomes showed a higher incorporation of radiolabled oleoyl-CoA into diacylglycerol, phosphatidylethanolamine, sphingomyelin and lysophosphatidylcholine lipid fraction in comparison with the control microsomes.

牛磺酸可改变微粒体膜脂质成分（如降低游离胆固醇、磷脂酰丝氨酸和鞘磷酸，升高磷脂酰乙醇胺和磷脂酸的浓度）和膜磷脂脂肪酸成份，并降低微粒体膜脂质的流动性。

Objective: Novel liposomes composed of hydrogenated soybean phosphatidylcholine and soybean phosphatidylcholine was prepared to encapsulate total alkaloids from seed of Strychnos nux-vomica. The pharmaceutical properties of the novel liposomes were compared with corresponding HSPC or SPC liposomes.

中文摘要：目的：制备了以氢化大豆磷脂和普通大豆磷脂为膜材的马钱子总生物碱复合磷脂脂质体，并与相应的单一磷脂脂质体比较药剂学性质。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

Thus, the su tance know in commercial as "lecithin" is designated 1,2-diacyl--glycero-3-pho hory is used for the portion of the molecule exclusive of choline.

卵磷脂是胆碱磷酸甘油酯，也称为磷脂酰胆碱或最好称为3--磷脂酰胆碱。磷脂酰一词用来表示除胆碱以外的那一部分卵磷脂分子。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。