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Herein, we report the enantioselective total syntheses of slagenins A-C and their antipodes. Starting from readily available ethyl -4-chloro-3-hydroxy-butanonate, elongation of the carbon chain with diazomethane, followed by oxidation of the given α-diazoketone using distilled DMD, afforded a key intermediate α-ketoaldehyde .

本文从方便易得的-4-氯-3-羟基-丁酸乙酯出发，经重氮甲烷延伸碳连、DMD氧化相应的α-重氮酮，制得α-酮醛；该化合物与尿素在氢氟酸作用下，以协同方式非对映选择性的直接构建了cis-四氢呋喃并[2，3-d]咪唑啉-2-酮双环结构，进而合成了天然产物slagenins A、B、和C的对映体。

Methods: Mice bearing in vivo transplanted tumor-H22 hepatic carcinoma were used to evaluate the drug"s activity of anti-tumor and GAPSGF"s efficacy enhancing effect by calculating the ratio of antitumor and q. HE dyeing was applied to observe the tumor"s morphological changes after the anti - tumor drug. It is observed the change of theperipheral white blood cells in serum and the body weight to analyze the GAPSGF"s toxicity reducing effect on the anti - tumor drug-Cytoxan. Applying ELISA method to observe the change of IL-2 in serum ,Applying carbon clearance method to test the function of uninuclear phagocyte,took the weight of the spleen and thoracic gland, analyzed the mechanism — efficacy enhancing and toxicity reducing of GAPSGF.

构建体内动物移植性H_(22)肝癌模型，通过计算抑瘤率与q值来分析药物的体内抗肿瘤活性，判断树舌多糖GF注射液的增效作用；采用瘤组织常规HE染色观察药物作用下的肿瘤细胞形态变化；观察外周血WBC数和体重改变来分析树舌多糖GF注射液对环磷酰胺抗肿瘤的减毒作用；采用ELISA法测定血清IL-2、小鼠碳粒廓清法测定单核吞噬细胞功能、取胸腺与脾脏称重测定脏器指数等以分析树舌多糖GF注射液增效减毒的作用机制。

Among the organophosphorus flame retardants, caged bicyclic phosphates have been in greatfavor, and many investigations have been done about them. It is found that caged bicyclicphosphates and their derivatives can serve as effective flame retardants to some polymers.

以季戊四醇为基的双环笼状磷酸酯及其衍生物兼具丰富的碳源和酸源，与三聚氰胺等配合使用可发挥良好的膨胀阻燃作用，因此它们的合成和应用倍受研究者的关注。

The reaction of carbodiimide 14 with various neucleophiles was investigated. The selectivity of cyclization of the carbodiimide 14 with NH_3, RNH_2, R_2NH and NH_2NH_2 were studied, some of the gualidene-type intermediates were isolated and the possible mechanism was suggested.

探讨了碳二亚胺14与各种亲核试剂如NH_3、RNH_2、R_2NH以及水合肼的成环反应的选择性，并分离得到了部分胍中间体，提出了反应可能的机理，对反应的选择性进行了合理的解释。

Part II:The electrocatalytic oxidation of guanine, adenine, guanosine-5'-monophosphate and ssDNA was performed in the presence of iron bis(2,2':6',2"-terpyridine) and Fe tris(1,10-phenanthroline) complexes as a homogeneous catalysts with Fe redox couple. The electrocatalytic and electroanalytic properties of guanine with an iron bis(2,2':6',2"-terpyridine) complex was measured by the amperometry method using the rotating disk electrodes. Electropolymerization of iron tris(5-amino-1,10-phenanthroline) complex produced thin polymer films on a gold, platinum, nickel, and glassy carbon electrode.

第二部分利用iron bis(2，2'：6'，2&-terpyridine)和Fetris(1，10-phenanthroline)之金属错合物当作均相的催化剂对於鸟嘌呤、腺嘌呤、5'-鸟嘌呤核苷单磷酸盐(guanosine-5'-monophosphate)和单股DNA进行电催化氧化的研究。iron bis(2，2'：6'，2&-terpyridine)之金属错合物对於鸟嘌呤的电催化和电分析性质可利用计时安培法并使用旋转环-碟电极进行测量。rontris(5-amino-1，10-phenanthroline)之金属错合物可经由电聚合过程所形成的聚合薄膜固定在黄金、白金、镍和玻璃碳电极上。

Wherein X is an oxygen atom or a sulfur atom; C*, C** and C*** are asymmetric carbons; R 1 , R 2 , R 4 , R 5 , R 8 , R 9 and R 10 are each a lower alkyl group optionally having substituent and the like, or R 4 and R 5 and the like in combination optionally form a homocyclic ring optionally having substituent and the like; R 3 is an aryl group optionally having substituent and the like; R 6 and R 7 are each a hydrogen atom and the like; Nu is -CR 16 (COR 17 )(COR 18 ) wherein R 16 , R 17 and R 18 are each a lower alkyl group optionally having substituent and the like, and the like; and EWG is an electron withdrawing group.

通式中，X代表氧或硫；C *、C **和C ***分别表示不对称碳；R 1 、R 2 、R 4 、R 5 、R 8 、R 9 和R 10 分别代表任选取代的低级烷基等，条件是例如R 4 和R 5 可以相互结合形成任选取代的同素环等；R 3 代表任选取代的芳基等；R 6 和R 7 分别代表氢原子等；Nu表示-CR 16 (COR 17 )(COR 18 )(其中R 16 、R 17 和R 18 分别代表任选取代的低级烷基等)等；并且EWG表示吸电子基团。

The two major categories are aliphatic, with the carbon atoms in straight or Branched chains or in nonaromatic rings, and aromatic

烃主要的两种类型是脂肪类和芳香类。。脂肪烃中的碳原子排成直线或分支的链，或者结成非芳香族的环。

The two major categories are aliphatic, with the carbon atoms in straight or branch ed chains or in nonaromatic rings, and aromatic

烃主要的两种类型是脂肪类和芳香类。。脂肪烃中的碳原子排成直线或分支的链，或者结成非芳香族的环。

The two major categories are aliphatic, with the carbon atom s in straight or branched chains or in nonaromatic rings, and aromatic

烃主要的两种类型是脂肪类和芳香类。。脂肪烃中的碳原子排成直线或分支的链，或者结成非芳香族的环。

With the increase of Mg2, the concentration of CO2 gradually reduces, and the majority of the volatile and semivolatile organic products, especially styrene monomer and some polycyclic compounds, take on increasing tendencies.

随着氢氧化镁含量的增加，二氧化碳的浓度逐渐降低；残渣中焦碳的含量以及大多数的挥发性和半挥发性有机产物，尤其是聚苯乙烯单体和一些多环化合物明显增加。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。