碘醇

Started from D-tyrosine, we obtained the tetramic acid 96 using Jouin reaction. The assembly of the second fragment 109 was stared from 1,4-butandiol,using asymmetric alkylation reaction developed by Oppolzer as a key step. Coupling of the tetramic acid 96 with 109 provided the key intermediate 110 according to Yoshii\'s procedure. After remove protective group and Sharpless epoxidation, we obtained the key intermediate 113. Its macrocyclization to form the final product is in progress.

本论文的第二章主要对Macrocidin A开展了合成工作，我们从D构型的酪氨酸出发，经过官能团转换；利用Jouin反应生成Tetramic acid 96，另外一个片断从1，4-丁二醇开始经过多步反应生成碘化物104，利用Oppolzer发展的手性樟脑磺酰胺为辅基参与的不对称烷基化反应，引入手性甲基，生成关键中间体109，接着通过Yoshii发展的方法连接96和109生成110，经过Sharpless不对称环氧化反应建立环氧化合物，然后脱去保护基得到关环前体113，分子内的Mitsunobu反应进行关大环反应正在进行之中。

A process for the carbonylation of allylic butenyl ether (for example, methyl crotyl ether, 3-methoxybutene-1 and mixtures thereof) or mixture of butadiene and alcohol and production of beta-gamma unsaturated carboxylic acid esters (for example, methyl-3-pentenoate) utilizing a rhodium-containing catalyst for example, dicarbonylacetylacetonate rhodium(I or the like promoted with an iodide-containing compound (for example, HI, AlI3, SnI4, TiI4, CrI3, and CoI2 or the like).

一种将烯丙型丁烯基醚(如甲基巴豆基醚、3－甲氧基丁烯－1及其混合物)或者丁二烯与醇的混合物羰基化的方法，以及由含碘化物化合物(如HI、AlI3、SnI4、TiI4、CrI3和CoI2或等效物)促进，用含铑催化剂如二羰基乙酰丙酮酸铑(I或其等效物制备β－γ不饱和羧酸酯(如甲基－3－戊烯酸酯)的方法。

Plain scan and enhanced scan were performed in these patients with Siemens 64-slice spiral CT with the following parameters: 1.0-mm section thickness,0.6-mm collimation,pitch of 1, voltage of 120Kv and tube current of 100mAs, The scanning range is from the thoracic inlet to posterior costophrenic angle; A 80-100ml dose of nonionic iodinated contrast material is injected intravenously at approximately 4-5 ml/sec.

扫描采用Siemens 64层螺旋CT；扫描参数选择层厚1 mm，准直0.6mm，螺距1，管电压120 kV，电流100 mAs；扫描范围从胸廓上口至后肋膈角；强化时对比剂为非离子型对比剂(碘海醇，350 mg I/ml)，注射流率4～5 ml/s，对比剂总量80～100 ml；采用人工智能触发扫描技术，触发点选择肺动脉主干横断层面，阈值为100 HU，触发扫描延迟时间为6 s。

AIM: To investigate the effect of PD98059, a specific repressor of extracellular signal regulated kinase1/2 (ERK1/2), on the proliferation of the murine lymphocytes. METHODS: Lymphocytes were isolated from lymphoid nodes of BALB/c mouse. After stained with carboxy fluorescein diacetate, succinimidyl ester, the cells were stimulated with polyclonal activators, concanavalin and phorbol 12,13 dibutyrate plus ionomycin.

分离小鼠淋巴结细胞，藉羧基荧光素乙酰乙酸染色，用多克隆刺激剂刀豆A蛋白或者佛波醇酯加离子霉素刺激，以流式细胞术分析PD98059对淋巴细胞增殖的影响；利用碘化丙锭染色分析PD98059对细胞周期的影响。

Methods: A model to evaluate lymphocyte proliferation stimulated with a polyclonal activator, concanavalin A, was established by vital dye carboxyl fluorescin diacetate succinmidyl ester labeling technique. Effects of the different doses of anisomycin on the lymphocyte proliferation were estimated by flow cytometry and MTT methods. The propidium iodide labeling technique was applied to assay the effect of the different doses of anisomycin on changes of the lymphocyte cell-cycle stimulated by ConA or by phorbol ester plus Ionomycin. The percentage of the expression level of CD69 and CD25 on the activated lymphocytes was evaluated by fluorescin-conjugated monoclonal antibody double labeling technique.

以活体染料羧基荧光素乙酰乙酸琥珀酰亚胺酯染色，建立在多克隆刺激剂刀豆蛋白A刺激下评价小鼠淋巴细胞增殖的模型，通过流式细胞术和MTT法分析茴香霉素在不同剂量下对淋巴细胞增殖的作用；采用碘化丙锭染色分析茴香霉素对ConA或佛波醇酯加离子霉素刺激的小鼠淋巴细胞周期变化的作用；利用荧光标记的单克隆抗体双染技术和流式细胞术观察茴香霉素对小鼠CD3~+T细胞早期及中期活化标志分子CD69和CD25表达的影响。

This paper optimized the reaction condition for alcohol-halogen acid method and dimethyl sulfate method based on reviewed the main means which iodomethane can be synthesized.

在综述碘甲烷常用制备方法的基础上，对醇氢卤酸法及硫酸二甲酯法进行了条件优化及对比总结。

The way to prepare iodomethane using methanol, potassium iodine and acid as regents has the disadvantages such as many side reactions and low yield, while the synthesize route from dimethyl sulfate and potassium iodine has the advantages of high yield and simple separation.

醇与氢卤酸作用是制备卤代烃的常用方法，以甲醇为试剂，以碘化钾与酸作用生成氢碘酸制备碘甲烷的方法存在副反应多、收率不高的特点；而以硫酸二甲酯及碘化钾为试剂的合成路线具有操作容易、收率高、纯化简单的优点。

The electronic effect of para substituents and both the steric and electronic effect of meta substituents in the substituted iodosobenzene were well linear correlated to the yields of cyclohexanol.

取代亚碘酰苯中对位取代基的电子效应和间位取代基的电子及立体效应对氧化产物环己醇的产率有良好线性相关性。

Catalytic Synthesis of Cyclohexanone 1, 2-Propylene Ketal by Chitosan Supported with Iodine

篇名 壳聚糖负载单质碘催化合成环己酮1， 2-丙二醇缩酮

By combining resolution and protection of DBSPINOL with menthyl chloroformate, the enantiopure SPINOL and other 4,4'-derivatives have been synthesized effectively via (1S)--4,4'-dibromo-l,r-spirobiindane-7,7'-diyl bis-menthyl carbonate with n-BuLi following reacting with electrophiles of I2, MeI, CO2 and water.

在制备其它衍生物反应中，薄荷醇碳酸酯成为羟基的保护基，DBSPINOL碳酸酯用正丁基锂处理后，再和亲电试剂作用合成了其它4，4'位二碘代、二甲基取代和二羧基取代SPINOL新化合物。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了