碘化

The reaction of polyfluoroalkyl iodides with 4-pentenoic acids initiated by sodium dithionite was realized to give polyfluoroalkyl substituted lactones.

我们研究了多氟烷基碘代烷与4-戊烯酸类化合物等在连二亚硫酸钠引发下的反应，得到了氟烷基取代的内酯化合物，我们将该反应称为氟烷基化内酯化反应；并建立了一个利用该反应合成含氟内酯的新方法，首次利用氟烷基化内酯化反应进行高立体选择性双环含氟内酯及手性含氟内酯等的合成，已合成含氟内酯新化合物50余种。

Experimental process: jing and 3- methyl -2- methyl ethyl ketonesynthesizes by the benzene zong; Again the glacial acetic acidcatalysis produces 2, 3, 3 - trimethyl - 3H - yinduo; Again has thealkylate response production yinduo iodide after the methyl iodide;The iodide takes off molecular HI under NaOH to become freejier thealkali; Adds 5 - nitryls salicylic aldehydes in the ethyl alcohol forthe solvent under if to respond finally produces 6 '- the nitryl yinduolin spiral benzene and pinan; Through the infrared spectrum andthe ultimate analysis irrevocably proved its structure, and studiedthe annulus with to open the annulus the light to send changes colorthe performance, explained in different solvent medium ultravioletabsorption spectrometry solvent effect, and the comparisondiscoloration the response speed number difference, finally mixed itadds to the methyl methacrylate, the peroxidation benzoin formyl in the plexiglass, tested 6 '- the nitryl yinduolin spiralbenzene and pinan in the glass fatigue resistance, thethermostability.

实验过程：由苯肼和3-甲基-2-丁酮合成腙；再冰醋酸催化生成2 ，3 ，3—三甲基—3H—吲哚；再经过碘甲烷发生烷基化反应生成吲哚碘化物；碘化物在NaOH下脱去一分子HI成为费歇尔碱；在乙醇为溶剂下加5－硝基水杨醛与其反应最后生成6'—硝基吲哚啉螺苯并吡喃；通过红外光谱和元素分析确证其结构，并研究了环体与开环体的光致变色性能，解释了在不同溶剂介质中紫外吸收光谱的溶剂效应，并比较褪色反应速率数的差异，最后将其掺加到甲基丙烯酸甲酯，过氧化二苯甲酰有机玻璃中，测试6'—硝基吲哚啉螺苯并吡喃在玻璃中的抗疲劳性、热稳定性。

In the Hanus method, an iodine bromide reagent is used instead of iodine monochloride.

在哈纳斯法中，溴化碘试剂代替氯化碘被使用。

This thesis consists of four parts as follows: Part I: ReviewThe purpose of the present review is to summarize the organic chemistry of polyvalent iodine compounds regarded as Chlorides, Fluorides, Oxidize reagents in the field of organic synthesis, especially focus on their synthetic application and space structure, there are lots of reaction examples to illustrate the incomparable merits of organic polyvalent iodine compounds in the synthesis of some drugs and natural products.

本论文由以下四部分组成：第一部分：文献综述本部分比较全面地回顾了有机含碘化合物作为氯化、氟化、氧化试剂在精细有机合成中的应用，主要针对含碘试剂的合成及其结构做了比较详细的综述，并且列举了大量反应实例引证了这种类型试剂在药物及天然产物合成方面具备的优势。

In a similar way, using N,N\'-dibenzyl tartamide as auxiliary,-(2-methyl)allyl-2-chloro-phenyl-methyl azide, a vital intermediate of Repaglinide, can be prepared via asymmetric allylation of o-chlorobenzaldehyde in

产物经氧化和碘加成内酯化反应得到阿伐他汀中间体(3R，5S)-3-羟基-5-碘甲基戊内酯(10)；将N-苄基酒石酸二酰胺用于邻氯苯甲醛的不对称烯丙基化反应以较高光学收率得-甲基烯丙基-2-氯苯基-甲基醇

Tetrachloroterephthalic acid was prepared by chlorinating terephthalic acid, oleumsolvent and iodine catalyst. Tetrachloroterephthalic acid was acylated by sulphurous oxychloride in the presence of DMF to form tetrachloroterephthaloyl chloride. The acyl chloride product was fluorinated by potassium fluoride and esterified by methanol to synthesize dimethyl tetrafluoroterephthalate. The ester was reduced with potassium borohydride and lithium chloride to give tetrafluoroterephthalyl alcohol. The above product was bromated in the hydrobromic acid to obtain 4-bromomethyl-2,3,5,6-tetrafluoro-benzene methanol. 4-Methyl-2,3,5,-6-tetrafluorobenzene ethanol was obtained by reducing the bromide with magnesium. In the exist of DCC and DMAP, tefluthrin was got by the condensation reaction between 4-methyl-2,3,5,6-tetrafluoro-benzene methanol and-(1RS,3RS)- 3-(2- chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cycolpropanecar-boxylate acid.

对苯二甲酸与氯气在碘存在下以发烟硫酸为溶剂进行氯化制备四氯对苯二甲酸；再以DMF为催化剂与二氯亚砜反应生成四氯对苯二甲酰氯；以氟化钾为氟化剂，环丁砜为溶剂置换氟化，再与甲醇酯化得到四氟对苯二甲酸甲酯；以KBH4-LiCl为还原剂二甲醚为溶剂反应制得四氟对苯二甲基苄醇；以氯苯为溶剂在溴化氢溶液中溴化得到溴化产物；在乙醇溶液中经镁粉还原得到4-甲基-2，3，5，6-四氟苄醇；甲基苄醇与功夫酸在催化剂二环己基碳二亚胺和4-二甲氨基吡啶作用下缩合得到七氟菊酯，总收率达43.6%。

The results showed polymeric diaryliodonium salts were effective aryl ion transfer reagents. Thirdly, a new type polymer supported hypervalent iodine reagents poly { [4-Hydroxy iodo] styrene} has been developed. It was an effective oxidative reagent, and could be applied to the one pot synthesis of 4-arylthiazoles.

然后，我们以聚苯乙烯羟基对甲苯磺酰氧基碘苯为原料，成功制备了一类新型聚合物高碘试剂—聚苯乙烯负载的炔基碘盐，并研究了其作为炔基转移试剂的有效性：(1)该试剂可对硫、氮、硒等负离子进行亲电炔基化反应，合成炔基亚砜、0，0-二烃基二硫代磷酸炔基酯、1-苯乙炔基苯并噻唑以及炔基硒醚。

In chapter 4, we have described an improved method for the preparation of ethynylferrocene. Ethynylferrocene was prepared in satisfactory yield by reaction of formylferrocene with triphenylphosphine and carbon tetrachloride followed by dehydrohalogenation in the presence of n-BuLi.

第三章中，我们研究了钯催化下碘杂环化合物的羰基化—酰胺化反应、羰基化—酯化反应和与末端炔烃的羰基化交叉偶联反应，为一步合成多官能团化合物开辟了新的途径，同时，得到的这些产物经过进一步官能团转化后，可以成为一些天然产物合成中的重要中间体化合物。

The recent research progress of oxidation carbonylation of amines/β-amino alcohols, alkoxycarbonylation of epoxides, carbonylative Suzuki coupling, carbonylative Sonogashira, and double carbonylation of aryl iodides has been presented, focusing on the carbonylation reactions studied by us in the past few years, with 81 references.

综述了胺／氨基醇类化合物氧化羰化、环氧化合物氢酯基化、碘代芳烃的羰化Suzuki偶联、羰化Sonogashira以及双羰基化等重要羰基化反应的研究状况，特别是结合本课题组近年来在该领域中的工作，并对羰基化反应的发展及应用前景进行了展望。

The quality values including melting point, iodine value (36.46g/100g, saponification value (197.10mg/g), etc were almost the same as that of CB iodine value (37.05g/100g), saponification value (195.30mg/g).

乌桕类可可脂的特征值(碘价36.46g/100g，皂化价197.10mg/g等)均与天然可可脂(碘价37.05g/100g，皂化价195.30mg/g)的相似。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。