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AIM: To investigate the effect of PD98059, a specific repressor of extracellular signal regulated kinase1/2 (ERK1/2), on the proliferation of the murine lymphocytes. METHODS: Lymphocytes were isolated from lymphoid nodes of BALB/c mouse. After stained with carboxy fluorescein diacetate, succinimidyl ester, the cells were stimulated with polyclonal activators, concanavalin and phorbol 12,13 dibutyrate plus ionomycin.

分离小鼠淋巴结细胞,藉羧基荧光素乙酰乙酸染色,用多克隆刺激剂刀豆A蛋白或者佛波醇酯加离子霉素刺激,以流式细胞术分析PD98059对淋巴细胞增殖的影响;利用碘化丙锭染色分析PD98059对细胞周期的影响。

In chapter one, at first, we simply outlined some reactions promoted by samarium diiodide in recent years.

第一章,首先我们综述了近几年来二碘化钐促进的有机反应在有机合成中的应用。

The first one is focused on the samarium diiodide promoted organic reactions and their applications in organic synthesis.

碘化钐促进的有机反应在有机合成中的应用;2。

The first one is focused on the samarium diiodide promoted organic reactions and their applications in organic synthesis.

第一章,首先我们综述了近几年来二碘化钐促进的有机反应在有机合成中的应用。

Nitroarenes can be reduced by samarium diiodide to afford a nitrogen anion,which is a living species and can be acylated by relatively weaker acylating ester agents.

碘化钐(SmI2)在四氢呋喃溶剂中还原硝基化合物,可以生成氮负离子中间体,该中间体具有较高的反应活性。

And then the intermolecular reductive cyclization reaction of N,N-diethyl-o-nitrobenzenesulfonamide with nitriles promoted by samarium diiodide was studied. 2H-1,2,4-Benzothiadiazine 1,1-Dioxides were prepared in good yields under mild and neutral conditions.

然后研究了二碘化钐促进的邻硝基N,N-二乙基苯磺酰胺与腈发生的分子间交叉还原偶联反应,一步合成了2H-1,2,4-苯并噻二嗪-1,1-二氧化物。

Treatment of dials with N-tert-butanesulfinamide, all biaryl dials were successfully converted into the corresponding bis-imines which were then treated with samarium diiodide to afford diamine products. The absolute configurations of all the intramolecular coupling products were determined by X-ray crystallography.

轴手性二醛与N-叔丁基亚磺酰胺缩合得到相应的亚胺,其为一对非对映异构体。N-叔丁基亚磺酰亚胺在二碘化钐条件下得到的偶联产物,经X-衍射也确定了其立体构型。

Studing on samarium diiodide promoted asymmetric intramolecular reducing coupling reactions, we have made the resolution of the racemic biaryl dials by using enantiomeric N-tert-butanesulfinamine as the resolving reagent successfully and thus obtained a series of axially chiral biaryl dials with high enantiomeric excess.

中文摘要在二碘化钐促进的分子内不对称还原偶联反应中,我们不仅对联芳基二醛底物的合成路线进行了优化,还发现N-叔丁基亚磺酰胺辅基可以作为手性试剂,成功地对联芳基骨架二醛化合物进行拆分,得到高对映体过量的轴手性二醛类化合物。

The side-effects of the chemical were horrific: with particles lodged in her cranium and forming cervical cysts, Dorine suffered enormous and mounting pain.

X 光技术中需要用射线不能穿透的碘化油作对比剂,而这种化学物质会带来可怕的副作用:粒子留存在她的颅腔中,同时还结成宫颈囊肿,巨大的病痛愈演愈烈,残酷地煎熬着多莉安。

In 1965 she had undergone a routine back operation which involved X-rays using the radio-opaque10 contrast agent lipiodol. The side-effects of the chemical were horrific: with particles lodged in her cranium and forming cervical cysts, Dorine suffered enormous and mounting pain.

而那时,妻子的身体状况已开始令人担忧。1965年她按照计划进行了背部手术,需要进行X光检查。X光技术中山网站建设需要用射线不能穿透的碘化油作对比剂,而这种化学物质会带来可怕的副作用:粒子留存在她的颅腔中山网站建设,同时还结成都网站建设宫颈囊肿,巨大的病痛愈演愈烈,残酷地煎熬着珠海网站建设莉安。

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这一模式非常关注商人的网络信用基础。

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