硼烷基

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

In one embodiment, the invention is a system for initiating free radical polymerization comprising: a in one part, one or more amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms and optionally containing one or more heteroatoms or heteroatom containing functional moieties, and one or more cationic counter ions and b in a second part, a liberating compound which reacts with the nitrogen atom bound to the boron atom upon contact with the amido-borate to form an organoborane radical.

在一个实施方案中，本发明是引发自由基聚合的体系，包括：a在一个部分中，一种或多种含有一个或多个包含有机硼酸根的阴离子酰氨基-硼酸盐部分和一个或多个阳离子抗衡离子的酰氨基-硼酸盐化合物，其中的硼原子键合到氨的氮原子或含一个或多个氮原子的有机化合物，例如烃基胺、烃基聚胺或含一个或多个氮原子和任选含一个或多个杂原子或含杂原子的官能部分的芳族杂环的氮原子上，和b在第二部分中，在与酰氨基-硼酸盐接触时与键合到硼原子上的氮原子反应形成有机硼烷基团的释放化合物。

In the process of laboratory study, oxycodone was prepared by oxidating thebaine at 6,14-position under oxydol, hydrodeoxidizing 7,8-position double bond and 14-position ether under palladium catalyst. Furthermore, N-methyl of oxycodone was isolated byα-chloro-ethyl chloroformate under anhydrous condition and protection of 14-position hydroxyl to obtain noroxycodone, which was further converted into methylnaltrexone by N-alkylation in presence of cyclopropyl bromomethane, then by isolating 3-position methyl of methylnaltrexone under boron tribromide, becoming hydrochloride to prepare target compound, natrexone hydrochloride.

实验室工艺方面，本文首先用双氧水氧化蒂巴因的6-位和14-位、在钯炭催化下加氢还原7-8位双键和14-位醚合成羟考酮，然后提出并优化了在无水和14-位保护的情况下，用氯甲酸-α-氯乙酯脱去羟考酮的N-位甲基合成去甲羟考酮，再用环丙甲基溴将去甲羟考酮的N-位烷基化合成甲基纳曲酮，最后采用三溴化硼脱去甲基纳曲酮的3-位甲基和成盐酸盐合成盐酸纳曲酮。

Which is made up of long carbon chain by N-alkylation or acylation,The surface activity is greatly enhanced because of structure of borate surfactants and the basic property of long carbon chain.

它们将长碳链通过N烷基化和酰化联接在一起的一类含硼表面活性剂，由于是含四配位硼氧杂环结构的表面活性剂和结合长碳链的基本性质从而极大的提高了表面活性。

Two benzothiazole ester compounds containing boron with different alkyl chain, Di-n-hexyl-[2-(2-benzothiazolylthio)] ethyl boric acid ester (BNS-1) and Dicyclohexyl-[2-(2-benzothiazolylthio)] ethyl boric acid ester(BNS-2), were synthesized and their tribological performance as additives in rapeseed oilwas investigated using a four-ball testing machine.

合成了两种含不同烷基链的含硼苯并噻唑酯类化合物，即二正己氧基-2-[(2-苯并噻唑基)硫代]乙氧基甲硼烷(BNS-1)和二环己氧基-2-[(2-苯并噻唑基)硫代]乙氧基甲硼烷(BNS-2)。

Work 工作:(1) feasible process development for high-pure tetraalkyphosphonium salt as catalysts for polymerizations, potential sale 2-4 million us$;(2) simple and feasible preparation process for phosphonium salt as ionic liquids, biocides and phase transfer catalysts;(3) new and industrially feasible processes for highly sterically hindered alkylphosphines as catalyst ligands, these include tricyclohexyl-phosphine, phosphorinanes and dsmphos2,3- bis(9-phosphabicyclononylbutane;(4) sterically hindered dialkylphosphinic acid as new generation of co/ni extractant;(5) alkylphosphonium wittig reagents and the wittig reactions with them;(6) exploration of the application of borane chemistry in the synthesis of highly sterocally hindered organophosphines;(7) customer preparation of samples of a variety of organophosphorus compounds for customers all over the world.

用作高分子聚合反应催化剂的高纯度四烷基瞵盐的实用生产流程。产品销售前景 2-4 百万美元；(2)用作离子化液体，杀菌剂和相转移催化剂的烷基瞵盐的简单实用合成方法；(3)高位阻烷基磷化氢催化剂配体的工业实用合成路线的研究，这包括，三环己烷基磷， phosphorinanes 和 dsmphos 2，3-bis(9-phosphabicyclononylbutane ；(4)高位阻二烷基膦酸金属萃取剂的工业实用合成路线的研究；(5)烷基膦 wittig 反应试剂的研究；(6)硼化学在高位阻烷基磷化氢合成中的应用；(7)为世界各地提供顾客合成服务。

At present, much attention had been paid to the study of the surfactants with four coordinate boron oxygen heterocycles structure, however, the main work was focused on the synthesis of the surfactants containing boron with short-carbon chain alkyls and their basic properties.

目前研究的方向主要是含四配位硼氧杂环结构的表面活性剂，但都是对一些含短链烷基的合成和基本性质研究，对含长碳链的还极少见文献报道。

Little literature on the aspect of surfactants containing boron with long-carbon chain alkyls had been found.Using diethanolamine, boric acid, hexadecanol as starting materials, after a series of reaction such as vapour phase process bromizating, esterifying, alkylating, a new type of surfactants with boron RNB had been obtained. The structures of the compounds had been identified by elemental analysis, IR and HNMR.

本论文采用二乙醇胺、硼酸、十六醇等为主要原料，经气相法溴化、酯化、烷基化等一系列反应合成了一种新型含硼表面活性剂RNB，并通过元素分析、红外、核磁对其结构进行了确认。

Finally, the influence of trialkyl borane BPh〓, B (c-hexyl 〓 and B 〓 on ethylene polymerization by metallocene was studied.

本文还研究了烷基硼化物BPh〓、B(c-hexyl〓和B〓对茂金属催化体系的影响。

The Aphos-Pd_2 system was proved very efficient for the coupling of alkyl boranes and the results are collected in Chapter 4.At the temperature of 50℃,a variety of aryl chlorides successfully coupled with alkyl boranes as well.

该类型配体对烷基硼试剂与溴代芳烃和烯烃的Suzuki偶联反应有着很好的效果，并且被成功地用于一系列氯代芳烃的反应，但反应温度为50℃。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。