硬化病

Results: The lesion located in the left choana region and left sphenoidal sinus of this case involved the left pharyngeal mucous space, left infratemporal fossa and its adjacent bone structure. CT showed that the rhinoscleroma in granulomatous stage was a soft mass which was irregular in shape, with a well-defined margin, inhomogeneous density and bone destruction. MRI showed heterogeneous hyperintensity on T1WI and isointensity on T2WI with an intermediate heterogeneous enhancement.

结果：病变起源于左侧后鼻孔及左侧蝶窦区，累及左侧咽粘膜间隙、左侧颞下窝及邻近骨质；结合本病例及文献复习，肉芽肿期鼻硬结病CT表现为不规则软组织肿块，轮廓清楚，密度不均匀，可见骨质破坏，残存骨质呈硬化改变；MRI表现为T1WI高信号T2WI等信号影，信号不均匀，增强后中度不均匀强化。

Aims :Chronotropic incompetence, an attenuated heart rate response to exercise, is an independent predictor of cardiovascular mortality, but it is not known whether chronotropic incompetence is related to carotid atherosclerosis.

目的：变时性机能不全是心血管病死亡率的独立预测因子，但是我们尚不清楚变时性机能不全同颈动脉粥样硬化是否相关。

Among 24 cases, lesions of 3 were found to be malignant(12.5%), in which 2 were carcinoma in situ, 1 were invasive duct carcinoma; the others were benign(87.5%), in which there were 9 cystichy perplas, 6 duct ectasia, 5 galactophore cirrhosis, 1 intraductal papillom.

乳腺癌3例(占12.5%)，其中导管原位癌2例，浸润性导管癌1例；良性乳腺病变21例(占87.5%)，其中囊性小叶增生9例，乳腺导管增生及扩张6例，硬化乳腺病5例，导管内乳头状瘤1例。

Methods:Arterial intimal thicknessABIand hsCRP were measured in 342 patients with hypertension.

目的：探讨超敏C反应蛋白及踝臂指数对高血压病患者颈动脉粥样硬化的预测价值。

Furthermore, both sclerodermoid and lichenoid subtypes responded.

而且，硬化型与苔藓样病变型均有效。

However, overall, a lobulated architecture is preserved.

所以，形态学特点是符合乳头部腺瘤伴有旺炽上皮增生和硬化性腺病改变的。

Most patients with this disease have a monophasic course, but a minority may have a recurrence. A diagnosis of multiple sclerosis should be considered if further neurological signs develop.

大多数的病患只经历单次的疾病，少数会复发，未来几10年仍需追踪，注意是否会演变为多发性硬化症。

In this review data on the use of rituximab is presented from 92 studies involving 1197 patients with the following diseases: systemic lupus erythematosus, idiopathic thrombocytopenic purpura, anti-neutrophil cytoplasmic antibody associated vasculitis, Grave's disease, autoimmune hemolytic anemia, pemphigus vulgaris, hemophilia A, cold agglutinin disease, Sjogren's syndrome, graft vs. host disease, thrombotic thrombocytopenic purpura, cryoglobulinemia, IgM mediated neuropathy, multiple sclerosis, neuromyelitis optica, idiopathic membranous nephropathy, dermatomyositis, and opsoclonus myoclonus.

本综述资料总结了92项共1197例患者应用利妥昔的研究，包括系统性红斑狼疮、特发性血栓性血小板减少性紫癜，抗中性粒细胞抗体相关性血管炎、甲状腺功能亢进、自身免疫性溶血性贫血、寻常型天疱疮、甲型血友病、冷凝集素病、干燥综合征、移植抗宿主疾病、血栓性血小板减少性紫癜、IgM介导性神经病、多发性硬化、视神经脊髓炎、特发性膜性肾病、皮肌炎和眼肌阵挛性肌阵挛。

Patients with nephrosclerosis, diabetic nephropathy and amyloidosis were selected as high mortality risk groups. Overall and cardiovascular mortality beyond 100 d in the low-risk group (n = 372) was 14% and 3.5%, and in the HRG (n = 99) 31% and 16%, respectively.

原发病为肾硬化、糖尿病肾病和肾淀粉样变的患者作为高死亡率危险组。100天后低危组（n = 372）总死亡率和心血管病死亡率分别为14%和3.5%，而HRG（n = 99）分别为31%和16%。

Objective In order to understand the role of the immune function in the pathogenetic mechanism of multiple sclerosis.

多发性硬化的病因尚不完全清楚，但其自身免疫的发病机制已得到证实和公认，属于特异性抗原介导的细胞免疫和体液免疫共同参与的中枢神经系统炎性脱髓鞘病。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。