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The alternative method of O-demethylation,methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

方法在以蒂巴因为原料,经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中,分别采用甲磺酸/DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

Results The synthesis condition was improved. The method of methane sulfonic acid/DL-methionine was found an ideal substitute of BBr3 for less cost. While using hydrobromic acid, the O-demethylation and hydrolyzation could be combined in one stage.

结果 优化了纳洛酮的合成工艺,甲磺酸/DL-甲硫氨酸法试剂价格低廉,可降低生产成本;而氢溴酸法不但试剂价格更低,还可将去氧甲基化和水解合并为一步反应,使新工艺的总收率提高到59.90%,产品质量符合中国药典。

In this thesis, two classes nonquaternary Cholinesterase Reactivators (1,2,4-oxadiazole and a -ketothio Hydroximic Acids derivatives ) and some clinical therapy used reactivators added to almost 40 cases have been caculated by using Comparative Molecular Field Analysis,ab initio and molecular mechanism methods. The characteristics of the molecular orbitals and the quantitative structure-activity relationship have been investigated.

本文利用比较分子力场法,量子化学从头算法,分子力学及计算化学回归分析等方法,对1,2,4-oxadiazole类非季铵肟胆碱酯酶复能剂,α—酮硫代异羟肟酸酯复能剂及部分现临床使用的复能剂,近40个化合物进行了计算,分析和研究了其电子结构和几何结构特征,建立了定量构效关系方程,得到了以下一些有意义的结果。

The construction process includes the following steps: constructing recombinant plasmid containing phhA and phhB; transforming the recombinant plasmid to hygrophilous aeromonad; and screening recombinant hygrophilous aeromonad with the recombinant plasmid.

该重组菌中含有β-酮硫解酶基因phbA和乙酰乙酰辅酶A还原酶基因phbB。其构建方法包括以下步骤:1构建含phbA和phbB基因的重组质粒;2转化该重组质粒到嗜水气单胞菌中;3筛选出含有重组质粒的重组嗜水气单胞菌。

It is found that the sensitivity of the photosensitive system with N-alkylthioacridone is improved strongly by further addition of diphenyl iodonium salt and actibator.

由硫代吖啶酮、二苯基碘鎓盐和活化剂组成的共引发体系使光聚合涂层的感度大大提高

Only Cr reacts with DDTC to form a 1: 3 complex which is then extracted with methyl isobutyl ketone and determined by flame atomic absorption spectroscopy.

本文拟定的方法是在pH-4条件下,用二乙胺硫代甲酸钠与甲基异丁基甲酮络合萃取铬,用原子吸收光谱法测定。

Firstly, polyacrylamide with 26 million molecular weight was compounded in lab through establishing optimum compounding initiator proportionality of 1:1. 3 and mass concentration of 170 mgL^(-1), temperature of 10 ℃, acrylamide mass percentage of 25%, electrical conductivity of 3.6 μSm^(-1) and pH value of 6.57. The salt-resistance, thermal endurance and shear-resistance of polyacrylamide could be enhanced b introducing sulfonic acid group or styrene sulfonate group or drawing the two groups above at the same time. Secondly, chelator HEDP, bactericide isoquinoline ketone and oxygen scavenger thiourea were optimized to improve the compatibility of polyacrylamide and formation water.

在由室内试验确定了复合引发剂最佳比值1:1.3和质量浓度170 mgL^(-1)、合成最佳温度10℃、丙烯酰胺单体质量分数25%、电导率3.6μSm^(-1)和pH值6.57后,合成出相对分子质量高于2.6×10^7的聚丙烯酰胺,同时通过丙烯酰胺单体复配引入磺酸基团、苯乙烯磺酸基团或同时引入此两种基团,提高了聚合物的抗盐、抗温、抗剪切性能;后针对聚丙烯酰胺与地层水配伍性差的问题,优选出HEDP螯合剂、异噻唑烷酮杀菌剂和除氧剂硫脲,对聚合物稳定效果明显。

Carotenoids in carrots and tomatoes, isothiocyanates in broccoli and cabbage, and flavonoids in soy, cocoa and red wine are just a few examples.

象胡萝卜和番茄中的胡萝卜素,花椰菜和洋白菜中的异硫氰酸酯,大豆,可可粉和红酒中的黄酮就是一些例子。

Carotenoids in carrots and tomatoes, isothiocyanates in broccoli and cabbage, and flavonoids in soy, cocoa and red wine are just a few examples.

例如,胡萝卜和番茄中的类胡萝卜素、椰菜和卷心菜中的硫氰酸盐、以及大豆、可可和红酒中的类黄酮。

Lipoic acid is an essential coenzyme in the oxidative decarb-boxylation of α-keto carboxylic acids.

α-硫辛酸作为一种辅酶,在α-酮酸的氧化脱羧过程中起重要作用。

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