硝氨基

PVC resin, PTFE resin, fumaric acid, anthraquinone, nitroanthraquinone, paraaminophenol, melamine, cyanuric acid, sulfanilic acid, chemical inhibitor 168, azoic coupling component As, stearate, aniline, nitroaniline, pentaerythritol, chlorcosane, sodium calcium, triethylene diamine, sodium benzene sulphinate, m-phthalic acid, thiourea, aniline black dyestuffs, acid dyestuff, etc.

聚氯乙烯树脂、聚四氟乙烯树脂、反丁烯二酸、蒽醌、硝基蒽醌、对氨基苯酚、三聚氰胺、氰尿酸、对氨基苯磺酸、抗氧剂168、色酚As、硬脂酸盐、苯胺、硝基苯胺、双季戊四醇、氯？？？腊、甲酸钙、三乙烯二胺、苯亚磺酸钠、间苯二甲酸、二甲酯五磺酸钠、硫脲、油溶性苯胺黑染料、酸性黑染料等有机化工原料和中间体。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Nine kinds of compounds are synthesized with NTO〓, PA〓, TNR〓'used as acid radical, and CHZ, SCZ·HCl, AG·H〓CP〓 served as the materials. Among them eight kinds of compounds have been never reported in the literature and one has been prepared at home for the first time. The structures of these compounds are characterized by using the element analysis and the FT-IR measurements.

以3-硝基-1，2，4-三唑-5-酮离子、2，4，6-三硝基苯酚离子、2，4，6-三硝基间苯二酚离子为酸根，以碳酰肼、盐酸氨基脲、氨基胍重碳酸盐为原料合成富氮化合物，得到了8种未见文献报道的新富氮化合物，另有1种是国内首次合成的新型富氮化合物。

The new synthetic technology of some important anthraquinone intermediates derived from 1-amino- anthraquinone, l-amino-4-hydroxy-anthraquinone, l-amino-4-bromo- anthraquinone-2-sulfonic acid, 1,5- and 1,8 dinitro- anthraquinone, have been studied.

本文研究了几种重要的由1-氨基蒽醌衍生的蒽醌型中间体：1-氨基-4-羟基蒽醌、1-氨基-4-溴蒽醌-2-磺酸和1，5-及1，8-二硝基蒽醌的合成化学，在此基础上开发了上述中间体的合成新技术。现行1-氨基-4-羟基蒽醌的生产技术是从1-氨基蒽醌出发，经二溴化再水解制得，溴的耗量在1.5mol以上。

When the resulting nitro compounds was reduced over 5% Pd/C catalyst, the nitro phosphinic acids required more catalyst that the esters nitro phosphinic acid, and dinitro compounds required more catalyst than mono-nitro compounds in the case of all nitro groups completely changed into amino groups.

用5％Pd/C作催化剂，将上述硝基物还原时发现，次膦酸形成的硝基物比次膦酸酯形成的硝基物需要更多催化剂才能使硝基全部还原成氨基；二硝基化合物比单硝基化合物需要更多的催化剂。

Amino-6-nitrobenzodifuroxan was prepared through a three-step reaction from starting material 3, 5-dinitrobenzoic acid:(1)3, 5-dinitroaniline (1) was synthesized from the reaction of DNBA and hydrazoic acid in inert solvent 1, 2-dichioroethane through Schmidt rearrangement with yield of 89.6%;(2) 1 was subjected to nitration to prepare pentanitroaniline (2) with yield of 51.1%;(3) The title compound was prepared from 2 and sodium azide in acetic acid through denitrogenation and then Schmidt rearrangement with yield of 86.8%, m.p.204℃～206℃.

以3，5-二硝基苯甲酸为原料经过3步反应合成了7-氨基6-硝基苯并二氧化吠咱：第1步反应，在二氯乙烷惰性溶剂中，DNBA与叠氮酸反应并发生Schmidt重排反应生成3，5-二硝基苯胺(1)，产率89.6%；第2步反应，1在含100%硫酸的硝硫混酸中硝化生成五硝基苯胺(2)，产率51.1%；第3步反应，2与叠氮酸反应，不经分离直接进行热解脱氮、Schmidt重排反应，得到目标化合物， m.p.204℃~ 206℃，产率86.8%。

The preliminary bioassays indicated that, at 500 g/mL, 1-(o-tolyl-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4g) and 1-(2,4-dimethyl- phenyl)-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonyl)semicarbazide (4k) showed inhibitory activities 90% and 80% against Blumeria graminis, respectively; and at 25 g/mL, 4-phenyl-4-(4-chloro-3-ethyl-1- methylpyrazol-5-ylcarbonylsemicarbazide (4c) showed inhibitory activity 70.1% against Botrytis cinerea and 1-2-nitro-phenyl-4-(4-chloro-3-ethyl-1-methylpyrazol-5-ylcarbonylsemicarbazide (4d) showed inhibi-tory activitiy 51.3% against Pyricularia oryzae.

初步生物活性实验结果表明，在500 mg/mL浓度下，化合物1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-(2-甲基苯基)氨基脲(4g)， 1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-(2，4-二甲基苯基)氨基脲(4k)对小麦白粉病菌的抑制率分别达到90%和80%；在25 mg/mL浓度下，化合物1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-苯基氨基脲(4c)对黄瓜灰霉病菌的抑制率达到70.1%；化合物1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-苯基氨基脲(4c)和1-(4-氯-3-乙基-1-甲基-1H-吡唑-5-甲酰基)-4-(2-硝基苯基)氨基脲(4d)对稻瘟病菌的抑制率均达到51.3%。

The results of biological tests indicated that, at 25 g/mL, 1-(4-bromo-3-ethyl-1-methyl-pyrazol-5'-ylcarbonyl-4-(2-nitrophenyl) semicarbazide (4d) showed inhibitory activities (52.6%) against Pyricularia oryzae. 1-(4-bromo-3-ethyl-1-methyl-pyrazol-5'-ylcarbonyl)-4-(3-chlorophenyl) semicarbazide (4j), 1-(4-bromo-3-ethyl-1-methyl-pyrazol-5'-ylcarbonyl)-4-(2,4-dimethylphenyl) semicarbazide (4k), 1-(4-bromo-3-ethyl-1-methyl-pyrazol-5'-ylcarbonyl)-4-(3,4-dimethyiphenyl) semicarbazide (41) and 1-(4-bromo-3-ethy-1-methyl-pyrazo1-5'-ylcarbonyl)-4-(2,4-difluorophenyl) semicarbazide (4m) showed inhibitory activities (45.6%) against Pyricularia oryzae, repestively.

初步生物活性实验结果表明，在25μg/mL浓度下，1-（1-甲基－3-乙基－4-溴－5-吡唑甲酰基）－4-（2-硝基苯基）氨基脲(4d)对水稻稻瘟病菌Pyricularia oryzae抑制活性达到52.6%；1-1-甲基－3-乙基－4-溴－5-吡唑甲酰基）－4-（3-氯苯基）氨基脲(4j，1-（1-甲基－3-乙基－4-溴－5-吡唑甲酰基）－4-（2，4-二甲基苯基）氨基脲(4k)，1-（1-甲基－3-乙基－4-溴－5-比唑甲酰基）－4-（3，4-二甲基苯基）氨基脲(41)和1-（1-甲基－3-乙基－4-溴－5-吡唑甲酰基）－4-（2，4-二氟苯基）氨基服(4m)对水稻稻瘟病菌Pyricularia oryzae抑制活性达到45.6%。

The o-aminobenzaldehyde ethylene acetals can be synthesized from corresponding o-nitrobenzaldehyde by reducing the nitro-group after the protection of carbonyl by ethylene. 2-Aminophenyl ketone ethylene ketal can also be prepared from 2-nitrophenyl ketones by this method.

邻氨基苯甲醛乙二醇缩醛可以由含不同取代基的邻硝基苯甲醛经羰基以乙二醇缩醛保护后还原硝基得到，邻氨基芳香酮乙二醇缩酮可以同样的方法由邻硝基芳香酮得到。

The effects of solvent type,concentration of the aqueous ammonia on the yields of target compounds were studied. The different results between 2,6-diamino-3,5-dinitropyridine (and 2,6-diamino-3,5-dinitropyridine-1-oxide) and 3-nitropyridien were analyzed.

探讨了溶剂类型、氨水浓度等反应条件对目标化合物产率影响，并讨论了2，6-二氨基-3，5-二硝基吡啶(2，6-二氨基-3，5-二硝基吡啶-1-氧化物)氧化胺化反应结果与3-硝基吡啶不同的原因。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。