砷化的

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

Examples are provided by the following preparations: arsenious sulphide from arsenious acid and hydrogen sulphide: gold or silver sols by reduction of the corresponding salts of gold or silver, silver chloride from very dilute solutions of silver nitrate and sodium chloride.

例子由以下准备提供：亚砷硫化物从亚砷酸和氢化硫：金或银sols 由金子或银，银色氯化物对应的盐的减少从非常硝酸银和氯化钠的稀溶液。

The results show that finer grained sediment samples tend to have higher concentrations of As and Pb.

研究结果发现磺港溪底泥中的砷、铅浓度皆会随著颗粒细粒化而明显地增加。

Objective To understand the situation of secondary skin cancer of hyperkeratosis of skin spot caused by coal-burning type of arsenic poisoning.

目的 了解燃煤型砷中毒皮肤角化点继发皮肤癌变的情况。

The cleanly production technology of second arsenic-alkali residue achieved the absolute separation of arsenic, soda and antimony in the lixivium.

二次砷碱渣清洁化生产技术实现了浸出后液中的砷、锑、碱的全分离，对于环境保护及资源的综合利用具有重要的现实意义。

Objectives To detect the methylation of P15(superscript INK4B) gene in patients with myelodysplastic syndromes and to investigate the demethylating effects of decitabine and arsenic trioxide (As2O3). Methods The bone marron mononuclear cells from 14 MDS patients were collected.

目的 检测骨髓增生异常综合征患者P15(上标 INK4B)基因甲基化状况；探讨5-氮杂－2'-脱氧胞嘧啶和三氧化二砷(As2O3)对MDS患者细胞的去甲基化作用。

MATERIALS AND METHODS: Using telomeric repeat amplification protocol assay and ABC immunohistochemical technique, the level of telomerase activation and PCNA expression were evaluated in 29 skin lesions of arseniasis patients and 10 cases of normal skin.

材料与方法：采用端粒重复序列扩增法和免疫组化ABC法检测29例砷中毒患者病损皮肤及10例正常皮肤组织中的端粒酶活性和PCNA表达情况。

Methods PCR-SSCP and PCR product cloning, sequencing were performed to detect mutation of p16 gene exon 2 in peripheral blood of 60 patients with arseniasis caused by coal-burning pollution,at the same time,PCR-based methylation assay was performed to analyze the methylation of p16 gene exon 1. Results No p16 gene exon 2 mutation was found in 60 cases.

采用聚合酶链反应-单链构象多态性分析和PCR产物克隆测序技术对60例砷中毒患者外周血中p16基因第2外显子突变情况进行检测，同时采用甲基化敏感的限制性内切酶方法对p16基因第1外显子甲基化情况进行分析。

The distribution of arsenic in coal has two genetic types:that is,terrigenous sediment and addition of epigenetic mineralization,and the arsenic abundance in the later is higher obviously than that in the former.

煤中砷的分布有两种成因类型：陆源沉积型、后期矿化叠加型，后者的含砷丰度显著高于前者。

Traditional copper surface roughening treatment involve the use of arsenide-containing electrolyte which is harmful to environment.

对铜箔表面进行粗化处理，传统的粗化工艺中要使用砷化物，不仅操作不便而且危害环境。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。