砷

Objective To probe into the situation and significance of p16 gene CPG island methylation in patients with arseniasis caused by coal-burning pollution.

目的了解抑癌基因p16启动子区CPG岛在燃煤型砷中毒患者中甲基化的情况和意义。

Cell proliferation played a critical role in the development of arseniasis caused by coal-burning.PCNA might be used as a biomarker for prognosis of the disease.

在燃煤型砷中毒发病过程中，细胞增殖起重要作用；PCNA可作为该病预后的生物标记物。

Objective To analyze the expression of skin proliferous cell nucleus antingen of patients with arseniasis caused by coal-burning.

摘要］ 目的分析燃煤型砷中毒患者皮肤增殖细胞核抗原的表达。

Human arseniasis is still the problem which has been paying close attention to so far in the internal and external medical field.

人类砷中毒至今仍是国内外医学界关注的课题。

MATERIALS AND METHODS: Using telomeric repeat amplification protocol assay and ABC immunohistochemical technique, the level of telomerase activation and PCNA expression were evaluated in 29 skin lesions of arseniasis patients and 10 cases of normal skin.

材料与方法：采用端粒重复序列扩增法和免疫组化ABC法检测29例砷中毒患者病损皮肤及10例正常皮肤组织中的端粒酶活性和PCNA表达情况。

Objiective: To explore wether urine porphyrins can be used as an exposure biomarker of endemic arseniasis.

目的：探讨尿中卟啉类化合物能否作为地方性砷中毒暴露性生物标志物并在实际工作中推广使用。

Objective In order to research arseniasis's mechanism on causing poisoning,especially resulting in skin carcinoma and search sensitive,practical monitoring index of DNA damage.

目的 探讨砷中毒的致癌机理及寻找灵敏、实用的DNA损伤监测指标。

As an important grain production base of North China, Hetao area can provide high-grade farm products. But there are some serious eco-geochemical problems including soil salification, which restricts regional agricultural development, and endemic diseases of arseniasis and fluorosis, which badly affect the human health.

作为我国北方重要的粮食生产基地可以为全国生产出优质的绿色产品；但河套地区也具有比较严重的生态地球化学问题，首先是土壤的盐渍化制约了河套地区农业的发展，其次是全区以砷氟中毒为主的地方病比较严重，极大地影响了该区人民的身体健康。

Methods PCR-SSCP and PCR product cloning, sequencing were performed to detect mutation of p16 gene exon 2 in peripheral blood of 60 patients with arseniasis caused by coal-burning pollution,at the same time,PCR-based methylation assay was performed to analyze the methylation of p16 gene exon 1. Results No p16 gene exon 2 mutation was found in 60 cases.

采用聚合酶链反应-单链构象多态性分析和PCR产物克隆测序技术对60例砷中毒患者外周血中p16基因第2外显子突变情况进行检测，同时采用甲基化敏感的限制性内切酶方法对p16基因第1外显子甲基化情况进行分析。

Arsenicalism causes evident damage of cellular energy metabolism and ultrastructure in rat brain.And the fetus rats are severely affected than the adults rats.

慢性砷暴露对大鼠脑细胞超微结构和能量代谢功能有明显损伤作用，仔鼠损伤程度比成鼠更严重。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。