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破骨细胞

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The histiological characteristcs, and activities of alkine phosphatase and acid phosphatase of the implantan were examined to study the effects of fluoride on biological activities of BMP.

结果 氟对BMP的生物活性有直接的影响,氟能促进BMP将更多的成纤维细胞转化为成骨细胞,并能增强成骨细胞的功能,加速钙盐沉积,而破骨细胞功能有所下降。

As for absorption percentage, no statistical differences were foundin femurs. But in vertebrae, raloxifene of 1mg/kg/d with estradiol valerate of0.4mg/kg/d had a significant lower value than the other 3 groups.

3在骨吸收指标每毫米破骨细胞数上,4个组在股骨和腰椎上无差异;在骨吸收周长百分数上,4组在股骨无差异,在腰椎,雷洛昔芬+高E2组要低于其他三组。

Methods: The multinucleated giant cells were separated from giant cell tumour and cultured with bone slice.

目的:比较骨巨细胞瘤中的多核巨细胞与破骨细胞骨吸收的功能特点。

Methods: The multinucleated osteoclasts were derived by 1,25-dihydroxyvitamin D3 and dexamethasone from bone marrow cells in the coculture system with primary osteoblastic cells.

采用原代培养的成骨细胞和骨髓单核细胞联合培养的方法,在1.25-2维生素D3和地塞米松作用下,使骨髓单核细胞分化形成破骨细胞

This review focused on the biological significance of matrix metalloproteinases in its regulation when mesenchymal stem cells differentiate into myoblastic, osteoblastic, chondroblastic, neural, and apidoblastic lineages.

文章详细阐述了基质金属蛋白酶在间充质干细胞分化为成肌细胞、成骨细胞、破骨细胞、神经细胞、脂肪细胞过程中所起的重要生物学作用,并对基质金属蛋白酶在间充质干细胞分化中的调控作用进行分析。

Objective: To observe the effects of berberine on osteoclastic differentiation and bone resorption action in vitro, and to investigate the cellular mechanism of its inhibitory effects on bone resorption.

目的:研究小檗碱对破骨细胞分化及骨吸收功能的影响,探讨小檗碱抑制骨吸收的细胞学基础。

Our results showed that serum TRAP can be a sensitive marker for osteoclastic function in bone metabolism;it is of significance for clinic and basic research in bone metabolism.

结果说明:血清TRAP活性可作为骨代谢过程中破骨细胞功能的较灵敏的指标,对骨代谢的临床及基础研究具有重要意义。

RESULTS: HE staining showed that bone resorption in Ti treatment group was increased obviously and the structure of bone trabecula was disottlerly and osteoporotic, the volume of osteoclast was enlarged and number was increased. The findings were reduced in etanercep groups, especially in 200 μg/kg group.

结果:苏木精-伊红染色结果为单纯钛处理组骨吸收明显增加,骨小梁结构紊乱及骨质疏松,破骨细胞的形态变大,数目变多;依那西普干预组上述表现减轻,尤以200μg/kg剂量为明显。

Transiliac bone biopsy showed highly increased bone mass (+63% versus age- and sex-matched controls), a decrease in bone remodeling without evidence of active osteoblasts, and a severe decrease in the dynamic parameters of bone formation (mineralizing surfaces,-90% and bone formation rate,-93% versus age- and sex-matched controls).

经髂骨的活检示骨量显著增加(与年龄和性别匹配的对照者相比增加了63%),骨重建降低且没有发现破骨细胞活化的证据(与年龄和性别匹配的对照者相比:矿化面-90%,骨形成率-90%)。

The third passage osteoblasts were plated at the density of 5×104/ml in 75ml culture flask, twenty four hours later treatment factors were added.

许多激素及细胞因子通过调节破骨细胞和成骨细胞这两类细胞的数量和活性,使骨量维持动态平衡。

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