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破骨细胞

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In the osteoporotic control group, the activities of serum AKU and TRAP, the masses of spongy bone and cortical bone of the femurs, and the quantity of the osteoclasts were increased, with the BMD of the lumbar vertebrae and tibia decreased, suggesting osteoporotic conditions.

对照组大鼠血清AKP和TRAP活性增加,股骨松质骨和皮质骨骨量减少,破骨细胞数量增加,腰椎、胫骨骨密度下降,呈现骨质疏松变化。

Ingrowth of blood vessel tissue and osteo-blast could be seen in both sides.

结果术后3周,硫酸钙尚可见残留颗粒,自体骨完全降解;植骨区域内均可见到大量的破骨细胞,并有血管纤维组织长入。

The tumor was excised and was found to be composed of bony trabeculae in a fibrotic stroma with many osteoclasts, a finding consistent with osteitis fibrosa.

切除肿块后发现肿块的成分为骨小梁和纤维化机制,机制中有许多破骨细胞,此发现与纤维性骨炎相符。

In vivo, CD11b+-cre/Dicer-null mice had mild osteopetrosis due to decreased osteoclast number and bone resorption.

体内实验发现,由于破骨细胞数目减少以及骨吸收作用降低,CD11b+-cre/Dicer-null小鼠表现出轻微的骨硬化症。

The bones were harvested, then bones length and length of their diaphyses were measured under stereo microscope. The histomorphometric analyses on midlongitudinal sections of bones were performed.

16d胎龄雌性小鼠尺骨在含有葛根素的BGJb培养基中旋转培养4 8h后,测量骨总长和骨干长度;HE染色,光镜下计数破骨细胞和肥大软骨细胞。

For this purpose, it is necessary to create scaffolds that can be degraded by osteoclasts and enable osteoblasts to build new mineralized bone matrix.

为了这一点,人们有必要创造一种支架,它不仅可以被破骨细胞降解也能让成骨细胞在其中生成新的矿化骨基质。

Since the osteoclast is the only cell in the body that is capable of resorbing bone, understanding its biology will be necessary for developing a new therapeutic approach for osteoporosis.

因为破骨细胞是体内唯一能吸收骨的细胞,建立治疗骨质疏松新方法有必要了解其生物学特性。

Osteoblasts are seen lining the irregular trabeculae, and there is an osteoclast near the center.

不规则骨小梁周围可见成骨细胞排列,中心部位可见破骨细胞

At the end of the culture, PBMCs cultured on coverslips were fixed and stained for tartrate resistant acid phosphatase, a marker of osteoclast.

对培养终末细胞作组织化学染色,检测破骨细胞特征性标志物抗酒石酸磷酸酶的表达;并以象牙磨片上虫蚀样骨吸收陷窝的形成为指标检测其生物学活性。

Alcohol primarily induce changes in MSCs, osteoblasts and osteoclasts, such as the proliferation, differentiation and function. As a result, it inhabit bone formation and promote bone resorption, fat increased and a series of pathophysiological changes.

目前认为酒精主要通过改变MSCs、成骨细胞、破骨细胞等的增殖、分化和功能,抑制成骨、促进骨吸收,引起骨组织形成减少同时脂肪组织增多等一系列病理生理变化,最终形成骨质疏松。

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