破骨细胞

In contrast, it decreases osteoclastic cell differentiation and resorbing activity, and increases osteoclast apoptosis.

同时雷奈酸锶还可以抑制破骨细胞分化和破骨细胞活性并刺激破骨细胞凋亡。

Cytotoxic action on osteoclasts was significant at 10-1mol/l ～10-3mol/l fluorine, and acute cell death was found in 10-1mol/l and 10-2mol/l fluorine groups under phase-contrast photomicroscope. Inapparent changes were observed in 10-4mol/l～10-7mol/l fluorine groups.

倒置相差显微镜下10-1mol/L～10-3mol/L氟对破骨细胞呈现明显毒性反应。10-1mol/L、10-2mol/L可致破骨细胞急性死亡。10-4mol/L～10-7mol/L氟对破骨细胞形态的影响不明显。

ESEM showed on one highly mineralized construct that partial displacement of oneosteoclast exposed specialized structures of the cellular membrane facing the bonesurface, namely, the ruffled border and podosomes of the sealing zone, as well as theresorption pit under the ruffled border, unequivocally indicating that osteoclast-likecells formed have the ability to resorb bone-like matrix produced by osteoblasts invitro.

细胞在大矿化结节周围分布的差异反映了在大小类似的情况下，结节矿化程度越高，对周围的TRAP阳性细胞的趋化能力越强。F-actin荧光染色显示了在大矿化节结上F-actin环的出现，这是破骨细胞具有吸收活性的特征标志，直接证明了所形成的类破骨细胞具有骨吸收活性。

Emerging evidence indicates that both osteoclastic activity and osteoblastic activity are required for the development of prostate cancer bone metastasis.

愈来愈多的证据显示，破骨细胞和成骨细胞共同参与了前列腺癌的骨转移，调节破骨细胞和成骨细胞的细胞因子影响前列腺癌细胞的发展与转移。

Now it is accepted that osteoblasts, in addition to being directly responsible for bone formation, also indirectly control bone resorption by mediating osteoclastic precursor cells differentiation and mature osteoclasts function.

现在普遍认为成骨细胞除了具有骨形成的直接功能以外，还能够通过介导破骨细胞前体细胞分化和成熟破骨细胞活化过程间接控制骨吸收。

For normal adult male rat,calcitonin depresses the osteoclastic resorption obviously through reducing the number of active resorptive surface and depressing osteoclastic activity;on the other hand,calcitonin depresses the osteoid producing activity of osteoblasts by indirectly affecting the coupling process between resorption and formation.Calcitonin administered in short did not affect the bone volume.

降钙素对正常成年雄性大鼠松质骨而言，可以明显抑制破骨吸收，这种作用可能是通过减少活性吸收表面数量和降低破骨细胞的吸收功能来完成的；可以抑制成骨细胞形成类骨质的活性，这种作用可能不是直接的，而是通过降钙素对骨吸收的抑制作用进而影响了骨吸收与骨形成的之间的偶联而完成的；短期应用降钙素骨量无变化。

Results As compared with control group,the bone trabecula was thinner in experiment group,and the bone structure was rarefaction and disorder, with less bone mass.

结果 与对照组比较，实验组骨小梁纤细，结构稀疏紊乱，骨量少，部分骨小量断裂，成骨细胞和破骨细胞数量均增多，骨陷窝内破骨细胞活跃；骨密度下降。

The culture was treated with lutein of different concentrations 10^(-8mol/L、10^(-7)mol/L、10^(-6)mol/L, respectively. The culture cells were fixed and were stained for tartate-resistant acidic phosphatase after 7d. The formation of osteoclasts was quantified by counting the number of TRAP(superscript +) multinuclear cells. The percentage of bone resorbed surface, TRAP activity and the expression of receptor activator of NF-KB mRNA were analysed. The appearance of reduced mice osteoclasts was typical.

受试细胞分为对照组、叶黄素低剂量组10^(-8mol/L、叶黄素中剂量组10^(-7mol/L和叶黄素高剂量组10^(-6mol/L，并设立空白对照组。7 d后取细胞玻片进行抗酒石酸酸性磷酸酶染色，观察破骨细胞并计数；取骨片进行甲苯胺蓝染色，光镜下统计骨吸收陷窝面积；测量抗酒石酸酸性磷酸酶活性以及破骨细胞表面NF-κB活化受体mRNA表达量。

In this study, we could not find significantly less root resorption lacuna and significantly less TRAP activity in the IL-1 group than in normal group, but there was significant difference betweens TNFα group and normal group.

其中IL-1调控于破骨细胞前体的分化阶段，TNF α调控成熟破骨细胞功能激活阶段。2：RANKL／RANK调控系统既作用于破骨细胞前体的分化、成熟，又作用于功能激活阶段。

After culture on coverslips and bovine cortical bone slices for 1, 3, 5, and 7 days, morphologic features, TRAP staining and bone absorptive lacunae were observed to evaluate osteoclast cells.

结果显示，当培养细胞在RANKL和M-CSF联合作用下，TRAP阳性染色的单核和多核破骨细胞可在3天内迅速形成，骨片吸收实验显示骨片上出现典型的骨吸收征象；在M-CSF(50ng/ml)协同作用下，RANKL呈剂量依赖型诱导TRAP阳性破骨细胞生成。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。