破骨细胞

How mitochondrial biogenesis is integrated with osteoclast differentiation is unknown.

但线粒体的生物发生是怎样和破骨细胞的分化整合到一起的还不清楚。

Objective: To purify and identify the osteoclasts from the tissue of human giant cell tumor of bone.

目的从人骨巨细胞瘤组织中分离纯化及鉴定破骨细胞。

Compared with the control group, the number of TRAP(superscript +) multinuclear cells, TRAP activity and the percentage of bone surface in lutein middle-dose group and lutein high-dose group significantly decreased (P.05). But the expression of RANK mRNA significantly increased (P.05) by treated in different doses of lutein.

诱导培养的破骨细胞形态特征明显；叶黄素中、高剂量组在细胞数量、TRAP活性上与对照组相比有明显统计学差异(P.05)；叶黄素各剂量组在mRNA表达量上与对照组相比有明显统计学差异(P.05)，且呈量效关系。

Compared with the control group, the number of TRAP+ multinuclear cells and TRAP activity of trans-resveratrol middle-dose group and trans-resveratrol high-dose group have significantly decreased (P.05). But the expression of RANK mRNA has significantly increased (P.05) being treated in different dose trans-resveratrol.

结果 诱导培养的破骨细胞形态特征明显；反式白藜芦醇中、高剂量组在细胞数量、TRAP活性上与对照组相比有明显统计学差异(P.05)；反式白藜芦醇各剂量组在mRNA表达量上与对照组相比有明显统计学差异(P.05)，且呈量效关系。

Results: The TRAP positive multinuclear cells were induced from rat marrow mononuclear cells after inoculating for 5 clays. RT-PCR analysis showed that ASIC1, ASIC2 and ASIC3 mRNA were present in the osteoclasts, and the corresponding proteins expressions were detected.

结果：诱导5d后可见抗酒石酸盐酸性磷酸酶阳性多核细胞出现，大鼠破骨细胞在mRNA和蛋白水平均可检测到ASIC1、ASIC2和ASIC3基因的表达产物。

A large multinucleate cell found in growing bone that resorbs bony tissue,as in the formation of canals and cavities.

破骨细胞一种巨大的多核细胞，发现于吸收骨组织的生长骨中，如在管和腔的形成时的生长骨中

Part 2. Expressions of Involved Genes and Apoptosis in Osteoclastic Precursors

第二部分磨损颗粒对破骨细胞前体细胞相关基因表达及凋亡影响。

Therefore, RANKL, RANK, and OPG provide a ligand/receptor/soluble receptor system for the molecular basis of osteoclastic regulation by osteoblasts.

这样，RANKL，RANK以及OPG构成了一种配体／受体／可溶性受体调控系统，成为成骨细胞调控破骨细胞的分子基础。

Results When the osteoclasts were cocultured with primary osteoblasts, the growth of osteoblasts had more preponderances.

成骨细胞对破骨细胞分化及功能成熟的影响与两者的相对数量有关。

In the whole life of human being, bone is always in the process of new-old alteration, which means osteoclast absorbing old sclerotin and osteoblast forming new sclerotin.

人的一生中骨骼一直处于新旧更替的过程中，即由破骨细胞吸收旧的骨质，成骨细胞形成新的骨质。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。