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破骨细胞

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These early results suggest that serum TRACP levels correlate well with histological indices of osteoclasts and may serve as a specific marker for osteoclastic activity in patients with renal bone disease.

这些早期的结果显示血清TRACP水平与破骨细胞的组织学和一些其它的东西有良好的相关性能做为一个监测肾骨疾病患者骨质疏松的指标。

BACKGROUND: Serum tartrate-resistant acid phosphatase 5b is a new marker of potential clinical use to monitor osteoclastic activity and bone resorption rate.

背景: 血清抗酒石酸酸性磷酸 5b 是检测破骨细胞活性及骨重吸收比率的一个潜在临床使用的新标记物。

Calcitonin is a hormone, composed of 32 amino acid residues. The main function of CT is to suppress osteoclastic resorption of bones followed by decreases in serum Ca level in mammals.

降钙素是由32个氨基酸残基组成的一种多肽类激素,其主要生理功能是参与体内的钙磷代谢,通过抑制破骨细胞的活性,促进钙在骨中的沉淀,从而降低血钙含量。

Osthole and TCFC reduced the bone lose by decreasing the osteoclast formation, its TRAP activity, and osteoclastic bone resorption.

蛇床子素和蛇床子总香豆素是通过抑制破骨细胞的形成、抗酒石酸酸性磷酸酶的活性和骨吸收作用减少骨质丢失的。

These osteoclasts had low resorptive activity when incubated on bone slices.

将这些破骨细胞在骨片上进行培养时,其再吸收活性较低。

Results The eroded surface,active resorptive surface,nuclear number of osteoclasts in calcitonin group were less than in control group.

结果 骨吸收陷窝表面、活性吸收表面、破骨细胞平均细胞核数,降钙素组明显小于对照组。

PDGF can modulate the functional balance between OB and OC directely or obliquely, and promote bone fracture healing and bone defect repairs, which is considered as a unwounded method that replaces some operations to treat such kind of patients.

PDGF直接或通过与其他生长因子的协同作用,调节成骨-破骨细胞之间的功能性平衡,加快骨折愈合和其他骨病损伤修复。如能实现和骨生物材料有机结合,有望使无创治疗代替有创手术,从而使此类患者减轻痛苦,缩短疗程。

Methods Transgenic mice and the intercrossed progeny between the founder mice of human Cathepsin-K gene and wild ICR were detected by Southern blot hybridization with DIG labeling probe.

组织蛋白酶K是一种溶酶体含有的半胱氨酸蛋白酶,它有选择性的在破骨细胞引起的骨吸收中起特殊的作用[1,2 ] 。

Results ICD (0.5,5 and 50 μmol/L) caused dose-dependent reduction in the number of osteoclastic bone resorbing lacunae. The inhibitory effect ICD (5 μmol/L) was more remarkable than that of aminopropanediphosphonate. Both ICD and APD reduced the surface area of osteoclastic bone resorbing lacunae.

结果 ICD(0.5,5与50 μmol/L)使体外破骨细胞性骨吸收陷窝数目呈剂量依赖性减少,中等浓度(5 μmol/L)的抑制作用明显高于阳性对照药帕屈磷酸钠,两药均可使吸收陷窝表面积明显降低,而且ICD作用更明显。

But in the repaired area, we can see more osteoclasts, more osteocyte loculi, and their square enlarged.

但前者破骨细胞数量较多,骨陷窝数量和面积也较大,BMP免疫组化染色阳性较强。

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