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After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

Negative behavior outweighs positive behavior, so a bad apple can spoil the whole barrel, but one or two good workers can't "unspoil" it, researchers at the University of Washington said in the current issue of the journal Research in Organizational Behavior.

华盛顿大学的研究人员在最新一期的《组织行为研究》中指出,消极行为的影响力比积极行为大,所以一个坏苹果会毁掉整桶苹果,但一两个好员工却无法起到&反破坏&的作用。

Negative behavior outweighs positive behavior, so a bad apple can spoil the whole barrel, but one or two good workers can't "unspoil" it, researchers at the University of Washington said in the current issue of the journal Research in Organizational Behavior.

华盛顿大学的研究人员在最新一期的《组织行为研究》中指出,消极行为的影响力比积极行为大,所以&一粒老鼠屎坏了一锅汤&不足为奇,但一两个好员工却无法起到&反破坏&的作用。

ResultsCompared with group A and group C, significant increase in the levels of IL 8 and MDA and decrease in the activities of SOD and GSH Px were noted in group B (F=5.86-18.41,q=3.15-7.17, P.01); compared with group A, the activity of SOD and GSH Px was not changed markedly, the levels of IL 8 and MDA rised slightly but with no statistically significant. Mitochondria became vacuolated and deformed in group B, slightly swollen in group C.

结果 与A组、C组相比较,B组SOD、GSH Px的活性显著下降,MDA含量、IL 8浓度显著上升(F=5.86~18.41,q=3.15~7.17,P.01);与A组比较,C组SOD、GSH Px活性无明显变化,MDA含量及IL 8浓度轻微上升,但无统计学差异。B组肺组织线粒体破坏,呈空泡样变,C组仅见线粒体轻微肿胀。

STZ can induce chemical insulitis and autoimmune insulitis, destroy both alpha and deltas cells, and make vacuolization and fibrosis in islets.

STZ可同时诱发化学性胰岛炎和自身免疫性胰岛炎,破坏α细胞和β细胞,使胰岛出现空洞形成和组织纤维化。

This destroys, or ablates, the tissue at these locations and interrupts the triggers for the heart arrhythmia.

这破坏或消融在这些位置上的组织,并且中断对心脏心律失常的触发。

Thermal energy destroys the growths by coagulating the blood supply, while preserving healthy tissue.

热能破坏速度由凝固的血液供应,同时维护健康组织。

This kind of crime is the most serious official corruption, which is that government officials colluding with the organization with underworld society nature.

国家工作人员涉黑犯罪是与黑社会性质组织相互勾结的官员腐败,它严重地破坏了社会的安定局面和经济的健康发展,同时还损害了党和政府的廉洁形象。

And inflation, in the end, misdirects and disorganizes production.

而最终,通货膨胀将把生产引上错误的轨道,并破坏生产的组织。

Enshielding and conniving the crime of the organization with characteristic of sinister gang is that national public servants ensiled or connive it to break law, resulting in commit crime. It not only destroys social managing order, but also damages the normal order of national organ.

本罪既破坏了社会管理秩序,又侵害了国家机关的正常活动,在处理这类犯罪时,要注意这里的&包庇&是事后包庇,如果事前包庇,则认为是一种共同犯罪,应以组织、领导、参加黑社会性质组织罪论处。

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With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务,乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐,因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。

Closes the eye, the deep breathing, all no longer are the dreams as if......

关闭眼睛,深呼吸,一切不再是梦想,犹如。。。。。。