研究试验

In this paper, problems of trend test in clinical experiment are studied mainly by the statistical inference method under order restriction. The ori- gins of order restricted statistical inference are usually dated back to the early 1950s. At about the same time, a number of researchers started working inde- pendently on similar problems. The field developed rapidly during the 1960s and early 1970s and formed the more perfect theory of estimation and test- ing.

中文题名临床试验中的趋势性检验副题名外文题名 Trend test in clinical experiment 论文作者马艳萍导师史宁中教授学科专业概率论与数理统计研究领域\研究方向学位级别博士学位授予单位吉林大学学位授予日期2002 论文页码总数97页关键词临床试验趋势性检验数理统计约束下统计推断馆藏号BSLW /2003 /R311 /1 本文主要利用序约束下的统计推断方法对临床试验中的趋势性检验问题进行了研究。

Based on the current condition of Henan aluminum soil recultivation, we located an empty and waste area after exploited at Xiaoguan Mine of Changcheng Aluminum Industrial Company and carried out a series of experiment and research on soil recultivation there in terms of engineering recultivation, biological recultivation and soil ripeness.

依据河南省铝土矿土地复垦的现状，选取长城铝业公司小关铝土矿开采后的采空区、废石场进行土地复垦的试验和研究。主要进行了工程性复垦试验、生物性复垦试验、土壤熟化试验研究。

Three types of base asphalt and six SBS were used to produce SBS modified asphalt. The interaction of SBS modified asphalt was discussed in different states between the base asphalt and SBS based on their compositions. Through the traditional tests, such as penetration, soften point and ductility, and US SHRP tests, the results indicated that influences to affect the temperature susceptibility, high and low temperature performance, aging characteristics are base asphalt, SBS types and their dosages. The functions of penetration to viscosity and complex shear modulus G~* to complex dynamic shear viscosity η~* were set up, and then theviscosity-temperature susceptibility of wide temperature span and the calculation method of low temperature viscosity were obtained."Process" evaluation criterions, high grading critical temperature T_ and low grading criticaltemperature T_ , were suggested according to the high and low temperatureperformances of SBS modified asphalt. Using the experience of Repeated Creep and Recovery Test for Binders, a new high-temperature evaluation index,modification rutting factor G~*~(-9) was obtained. The results after RTFO and PAV aging indicated that traditional tests didnt differentiate base asphalt and SBS modified asphalt, but dynamic mechanics temperature spectrum and G*-5 black chart clearly reflected the influence of aging to the SBS modified asphalt. With the IR and GPC tests, the reason of aging to the SBS modified asphalt were due to asphalt phase oxygenated and SBS phase depredated.

论文选择3种油源的基质沥青和6种SBS改性剂制备改性沥青，通过分析基质沥青和SBS改性剂的组成结构特点，得出了不同状态下SBS改性沥青的SBS与基质沥青的相互作用机理；通过针入度、软化点、延度等常规试验以及美国SHRP试验，分析了基质沥青、SBS改性剂类型与剂量对SBS改性沥青的温度敏感性、高低温特性及老化特性的影响；建立了针入度-粘度、复数模量G~*-复数粘度η~*的换算关系，得出了宽温度域的粘温指数VTS和较低温度下粘度的计算方法；通过高低温性能分析提出了&过程&评价参数高温等级温度T_和低温等级温度T_；借鉴重复恢复与蠕变试验研究成果，得到了SBS改性沥青高温评价指标改进型抗车辙因子G~*~(-9)；RTFO和PAV老化后的性能试验结果表明，常规试验难以区分SBS改性沥青与基质沥青的差异，而动态力学温度谱、G~*-δ黑斑图可以反映老化作用对SBS改性沥青的影响，且通过IR试验和GPC试验得出SBS改性沥青老化是沥青相的氧化和SBS的降解共同引起的；通过不同温度下SBS改性沥青混合料的旋转压实SGC试验，根据粘度与剪变率的关系，提出用剪变率60(1／s)测试SBS改性沥青的粘温曲线，并按照0.17±0.02Pa.s和0.28±0.03Pa.s确定施工温度。

Measured the basic physical parameters of unsaturated soils in Three Gorges Reservoir area; 2 measured the initial sample matric suction using the unsaturated triaxial testing system, which can be used to evaluate the unsaturated soil strength and stress; 3 the drying and moisture absorption experiments were executed using the Tempe apparatus, and got the Soil-Water Characteristic Curve, permeability coefficients of every stress level were simulated according to the parameters from the SWCC; 4 the unsaturated soil strength tests were carried out using the GDS triaxial testing system, then got the Mohr circle and shear strength parameters; the results from different stress paths were compared; meanwhile, the axial strain-stress ratio-volume strain curve of different matric suction and different radial pressure was got, as well as their relationship; The research, which provided the necessary data and reference for Three Gorges Reservoir area geologic disaster, is the basic component of Three Gorges Reservoir geologic disaster prevention and research, and experimental results will be used directly in the project.

1量测了三峡库区非饱和土的基本物性参数； 2用非饱和土三轴试验仪量测了试样的初始基质吸力，为评估非饱和土的强度和应力水平提供参考； 3用Tempe仪和体积压力板仪进行了非饱和土的干燥和吸湿试验，得到了土-水特征曲线，并根据其参数拟合出各级吸力状态下对应的渗透系数； 4用GDS三轴仪进行了强度试验，得到了Mohr圆和抗剪强度参数；并比较分析了不同应力路径下试验结果；同时得到不同吸力和不同围压下轴向应变-应力比-体应变的关系曲线和其相互关系。该研究是三峡库区地质灾害防治研究工作的基础性工作，其结果将直接应用到工程实际中，为三峡库区地质灾害提供必要的数据和参考。

Based on the previous results, the method to derive creep constructive model from the indoor experiment data is studied, and these study works are also finished: the reasonable method to determine instance elasto-plastic deformation according to experiment curve, the optimization method to perform curve fitting based on experiment data, the universal method to derive creep constructive model from experiment results.

4在已有研究成果的基础上，对从室内试验数据成果导出流变本构模型的方法进行探讨，研究从室内流变试验曲线上确定瞬时弹塑性变形的合理方法，以及对流变试验数据进行曲线拟合的最优化方法，探讨由室内试验数据成果导出流变本构模型的一般性方法。

In 1999, the Liaoning provincial important Sci-Tec started a key problem project for the technology of protecting and preventing of dangerous river bank and plain reservoirs. Under the support of this project, this research was carried out for experiment of engineering properties and bank engineering applications of geosynthetics. In order to solve the life and soil retention criteria of geosynthetics problems in bank engineering applications, the indoor tests, in-situ tests, locale antitypes tests and observations, theory analysis, and engineering examples analysis have been performed.

结合堤岸防护工程实际条件，采取室内试验、野外试验、工程现场原型试验或观测以及理论分析和大量工程实例验证分析的方法，对堤岸防护工程中应用的土工合成材料相关工程特性，尤其是老化规律和较大孔径织造布保土性准则，进行了较系统、深入的试验研究；在此基础上，通过典型工程实例及大量工程应用实践总结分析，重点对土工织物软体排、土工模袋、土工膜堤岸防护工程的设计方法和施工技术进行了研究。

Detail Contents: Genetic disorders -- Immune deficiencies -- Breast cancer -- Colon cancer -- Melanoma -- Cystic fibrosis -- Hemophilia -- Liver disease -- Cardiovascular disease -- Muscular dystrophy -- Alzheimer's disease -- Parkinson's disease -- Huntington's disease -- Viruses: the cornerstone of gene therapy -- Viruses are living crystals -- Viral genomes may be RNA or DNA -- Viruses evolved from plasmids -- Viruses know how to infect cells -- The virus as a gene vehicle -- Viruses used in gene therapy -- Ashi DeSilva: a promising start -- Clinical trials defined -- Cells of the immune system -- Adenosine deaminase -- Preliminary research -- Clinical procedure for ADA gene therapy -- The DeSilva clinical trial -- Jesse Gelsinger: down to earth -- Ornithine transcarbamylase -- Preliminary research -- Clinical procedure for OTC gene therapy -- The Gelsinger clinical trial -- The investigation -- Concluding remarks -- Future prospects -- Safer vehicles -- Reducing immune rejection of the vector -- Improved risk assessment -- Redesigning human anatomy and physiology -- Ethics of gene therapy -- The Belmont report -- Clinical trials -- Physiological enhancement -- Cosmetic applications -- Legal issues -- Regulatory agencies -- The Gelsinger legal trial -- International regulation -- Resource center -- Eucaryote cell primer -- Recombinant DNA primer -- The human genome project -- X-linked severe combined immunodeficiency (SCID-X1)-- Alzheimer's disease -- Huntington's disease.

细节内容︰遗传疾病-免疫的缺乏-乳腺癌-结肠癌-黑瘤-囊性纤维变性-血友症-肝疾病-心血管疾病-肌营养不良-早老性痴呆病-帕金森疾病-亨廷顿疾病-病毒︰基础的基因治疗-病毒在活著水晶--病毒的基因可能是RNA或者DNA --病毒从plasmids被逐步形成--病毒知道怎样感染细胞--作为一辆基因车辆的病毒--基因治疗使用的病毒-Ashi DeSilva︰有希望开始-临床试验确定--细胞的这免疫系统-Adenosine deaminase-初步研究-临床程式给埃达基因治疗--这DeSilva临床试验-婕西Gelsinger︰到地球-Ornithine transcarbamylase-初步研究-临床程式给OTC基因治疗-- Gelsinger临床试验-调查-达成评论-前景-更安全的车辆--矢量的降低免疫的拒绝-改进风险估计-重新设计人解剖学和生理学--伦理学的基因治疗-那些贝拉蒙特报告-临床试验-生理提升-美容应用-法律问题-协调机构-- Gelsinger 合法审讯-国际管理-资源中心人物-Eucaryote信元第一-Recombinant DNA 入门--人类基因工程-- X 连结的严重的结合的免疫缺陷(SCID-X1)-早老性痴呆病--亨廷顿的疾病。

Its rule of change was obtained. On the basis of other studies, the flocculation kinetics and flocs structure was studied. By making some assumptions, collision frequency were presented. Then the the flocculation kinetics model was established through population balance equation. Comparison of experimental data and modeling results indicate that there are the same trend between the two. So the model can predict flocs number and size during flocculation of Yellow River's loess particles without using empirical parameters. The TEM and SEM were used to obsever flocs in the study of floc structure. The flocculation was divided as flocculi, floc and floc aggregate. The flocs structure model was established by assumption that particles position in floc accords with tetrahedron. The fractal dimension of model and experimental flocs was found to be coincident. So the model can reflect the structure of flocs formed in flocculation of Yellow River's loess particles by macromolecule flocculant at a certain extent.

最后，本文还对絮凝动力学和絮体结构进行了研究，在前人研究的基础上，针对高分子絮凝黄河泥沙，对絮凝过程作了一些符合试验条件的假设，建立了颗粒碰撞频率表达式，应用了颗粒数量平衡方程，从而建立了絮凝过程的动力学生长模型，模型计算结果与试验数据对比表明，二者趋势一致，在没有使用经验参数的情况下基本上能够描述黄河泥沙絮凝过程中絮体数量和尺寸分布的变化过程；对絮体结构的研究中，应用扫描电子显微镜和透射电子显微镜对絮体进行了观察，将絮体分为絮粒、絮团和絮网三个不同的生长阶段，通过假设颗粒结合位置符合正四面体，建立了絮体结构模型，计算得到的模型絮体分形维数基本与试验中的实际絮体相符，在一定程度上能眵反映高分子絮凝黄河泥沙生成的絮体结构。

Its rule of change was obtained.On the basis of other studies,the flocculation kinetics and floes structure was studied. By making some assumptions, collision frequency were presented.Then the the flocculation kinetics model was established through population balance equation. Comparison of experimental data and modeling results indicate that there are the same trend between the two. So the model can predict floes number and size during flocculation of Yellow River's loess particles without using empirical parameters.The TEM and SEM were used to obsever floes in the study of floe structure.The flocculation was divided as flocculi,floc and floe aggregate.The floes structure model was established by assumption that particles position in floe accords with tetrahedron.The fractal dimension of model and experimental floes was found to be coincidentSo the model can reflect the structure of flocs formed in flocculation of Yellow River's loess particles by macromolecule flocculant at a certain extent

最后，本文还对絮凝动力学和絮体结构进行了研究，在前人研究的基础上，针对高分子絮凝黄河泥沙，对絮凝过程作了一些符合试验条件的假设，建立了颗粒碰撞频率表达式，应用了颗粒数量平衡方程，从而建立了絮凝过程的动力学生长模型，模型计算结果与试验数据对比表明，二者趋势一致，在没有使用经验参数的情况下基本上能够描述黄河泥沙絮凝过程中絮体数量和尺寸分布的变化过程；对絮体结构的研究中，应用扫描电子显微镜和透射电子显微镜对絮体进行了观察，将絮体分为絮粒、絮团和絮网三个不同的生长阶段，通过假设颗粒结合位置符西安建筑科技大学博士学位论文合正四面体，建立了絮体结构模型，计算得到的模型絮体分形维数基本与试验中的实际絮体相符，在一定程度上能够反映高分子絮凝黄河泥沙生成的絮体结构。

Applications of face-fired boilers are not so many on our country's industry, So the researches on it, especially on high-duty boilers (for example 330MW), are very limited. And further study is needed to make up for domestic vacancy about this. Author of this paper has done some researches on 330MW boiler both in theory and experiments by applying Computer Aided Test principles. Numerical simulation is dominating part of CAT, also the core of this paper.

对冲燃烧锅炉在我国的应用并不是很多，所以对它所进行的研究极为有限，特别是对于较大容量(如330MW)的机组，相应的试验和数值计算都很少，很多的问题仍等待进一步的研究，本文正是为了填补国内的空白，从理论和试验的角度，运用计算机辅助优化数值试验原理和方法，对330MW对冲锅炉进行研究。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。