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Results Compared high kV X-ray chest film with spiral CT,to simplex silicosis,X-ray films coincided with CT scans;to mixed silicosis,the effect of CT scans were better than X-ray's;to large nodule,coalesced progressive massive fibrosis,the detected ratio of CT scans were higher than X-ray chest films;to silicosis complication,for example,emphysema,pleural thickening,phthisic,mediastinal impairment lympy node etc,CT scans were more reliable than X-ray films,especially HRCT can earlier find silicotic nodule and fine structure of focus.Selective application of CT scan,had great diagnostic value in complicated silicosis and silco-tuberculosis and lung cancer complicated with silicosis etc.

结果 高千伏X线胸片与螺旋CT作对比,结果对单纯矽肺并发肺癌,CT片与X线胸片基本一致;对于复杂矽肺并发肺癌CT优于X线胸片;对于大结节、肺内进行性大块纤维化(progressive massive fibrosis,PMF)融合、空洞及钙化CT检出率明显高出胸片;对矽肺并发肺癌的合并其他如肺气肿、胸膜肥厚、结核、纵隔淋巴受累等CT均较胸片可靠;特别是HRCT能早期发现矽肺肿块样病灶中细微结构,选择性应用CT,对复杂矽肺并发肺癌合并结核等鉴别诊断有很大价值。

AIM: To investigate the relationship between basic fibroblast growth factor and the development of silicosis in mice.

目的 :建立小鼠矽肺动物模型,探讨碱性成纤维细胞生长因子与矽肺进程的关系,揭示其在细胞以及分子水平的调控。

To find the best strategy for prevention and treatment of silicosis and reduce the incidence and mortality of silicosis.

目的 寻找防治矽肺的最佳策略,降低矽肺的发生率和死亡率。

Objective To determine the feasibility of rabbit as an experimental animal for establishing a silicosis model.

目的通过对大鼠和家兔矽肺模型在高分辨率CT图像和病理结果的对照分析,确定家兔在复制矽肺模型上的可行性。

Background: The interaction between macrophages and SiO2 is generally believed to play an important role in silicosis formation.

背景:矽肺的发病机制中,一般认为肺巨噬细胞与石英(SiO2)相互作用而产生的诸多因子在矽肺发生发展过程中起到关键性作用。

Spiral CT is superior to radiography in detecting the silicotic nodule and complications, and it has a practical value in the diagnosis of this condition.

螺旋CT在矽肺大小结节的显示及并发症的检出上优于X线平片,对矽肺的正确、综合诊断具有重要价值。

ConclusionSpiral CT is superior to radiography in detecting the silicotic nodule and complications, and it has a practical value in the diagnosis of this condition.

螺旋CT在矽肺大小结节的显示及并发症的检出上优于X线平片,对矽肺的正确、综合诊断具有重要价值。

The results showed that SiO2 and total protein contents, PAM numbers and LDH activity in silicotic rats decreased gradually with the severity of silicotic pathologic changes.

结果表明,矽肺大鼠BALF中SiO2粉尘和总蛋白量以及细胞总数和LDH活性,均随矽肺病变加重而逐渐减少。虽然,BAL对不同程度矽肺病变均能洗出一定量的细胞和非细胞成分的物质,但以早期病变组排出量最多。

Furthermore, the complications detected by spiral CT and chest radiography were as follows: emphysema was detected in 11 cases by CT and six by radiography; pulmonary tuberculosis was detected in five cases by spiral CT and three by radiography; lymph node enlargement or calcification in mediastinum or pulmonary hilus were detected 21 cases by CT and 15 by radiography.

CT检出矽肺并发肺气肿11例,X线胸片检出6例;CT检出矽肺并发肺结核5例,X线胸片检出3例;CT检出矽肺并发纵隔和肺门淋巴结大或钙化21例,X线胸片检出15例。

Furthermore, the complications detected by spiral CT and chest radiography were as follows: emphysema was detected in 11 cases by CT and six by radiography; pulmonary tuberculosis was detected in five cases by spiral CT and three by radiography; lymph node enlargement or calcification in mediastinum or pulmonary hilus were detected 21 cases by CT and 15 by radiography.

CT检出矽肺并发肺气肿11例,X线胸片检出6例;CT检出矽肺并发肺结核5例,X线胸片检出3例;CT检出矽肺并发纵隔和肺门淋巴结或钙化21例,X线胸片检出15例。

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