瞳孔不等

The most common reported clinical symptoms are: hearing impairment (95%), cerebellar ataxia (88%), pyramidal signs (76%), dementia (24%), anosmia (17%), anisocoria (10%) and sensory signs (13%).

最常见的临床表现为：听力损害（95%）、小脑性共济失调（88%）、锥体束征（76%）、痴呆（24%）、嗅觉丧失（17%）、瞳孔大小不等（10%）、感觉症状（13%）。

Results there were unconsciousness, respiratory rhythm disturbance and hyporeflexia of pupil light reflex immediately after injury, and reactiveness decrease and activity retardation still existed even after resuming consciousness. at anatomical scene, subarachnoid hemorrhage or cerebroventricular haemorrhage were widespread. at an early stage, there were swelling, collapse, and axonal retraction ball formation at cortico-medulla junction, callosum, brainstem, and cerebellar white matter under microscope. but at the later stage, gitter cell proliferation and nest-like aggregation were major pathophysiological changes at focal brain tissue.

结果 伤后大鼠均即刻出现原发昏迷，其中2只于损伤后20 min内死亡，余持续时间1-30 min不等；伤后大鼠呼吸节律紊乱，瞳孔对光反射减弱或消失，醒后均有程度不等的反应性下降，肢体活动迟缓；肉眼可见广泛蛛网膜下腔出血或脑室出血；光镜下可见皮髓交界区、胼胝体区、脑干、小脑白质等部位的神经轴索有不同程度的肿胀、断裂、轴索球形成，后期有小胶质细胞增生，局部呈巢样聚集。

Cases of anisocoria have been reported from exposure of the eyes to aerosol bronchodilators.

暴露于使用气溶胶给支气管扩张剂时双侧瞳孔大小不等的病例已经有报道。

The index case was a 5-month-old infant girl who had anisocoria from 4 weeks of age. One hour after 1% apraclonidine hydrochloride was instilled in each eye, there was blanching of the periocular skin, and the parents reported that the infant was excessively drowsy. Two hours after receiving apraclonidine, the infant was taken to the emergency department for lethargy and unresponsiveness, with bradycardia (84 beats/min), shallow respiration (40 breaths/min), and blood pressure 115/85 mm Hg. Oxygen saturation was 80% but improved rapidly to 100% when oxygen was given via a face mask. Eight hours after receiving apraclonidine, the infant had returned to normal.

指标案例是一名5个月大的女婴，她从4周大时就有瞳孔大小不等的状况；在1%的apraclonidine氯化氢徐徐滴点她的双眼后1个小时，眼眶周边的皮肤即变白，而她的家长表示她变得非常嗜睡；在使用apraclonidine 2个小时之后，该名女婴因嗜睡和无应答性，以及心搏过慢（每分钟84下）、呼吸浅弱（每分钟40次）以及血压115/85 mm Hg等症候而被送进急诊室；血氧饱和度原先为80%，在面罩给氧后迅速回复到100%，在使用apraclonidine 8个小时后，该名女婴终于回复健康状态。

The index case was a 5-month-old infant girl who had anisocoria from 4 weeks of age. One hour after 1% apraclonidine hydrochloride was instilled in each eye, there was blanching of the periocular skin, and the parents reported that the infant was excessively drowsy. Two hours after receiving apraclonidine, the infant was taken to the emergency department for lethargy and unresponsiveness, with bradycardia (84 beats/min), shallow respiration (40 breaths/min), and blood pressure 115/85 mm Hg. Oxygen saturation was 80% but improved rapidly to 100% when oxygen was given via a face mask. Eight hours after receiving apraclonidine, the infant had returned to normal.

指标案例是一名5个月大的女婴，她从4周大时就有瞳孔大小不等的状况；在1%的apraclonidine氯化氢徐徐滴点她的双眼后1个小时，眼眶周边的皮肤即变白，而她的家长表示她变得非常嗜睡；在使用apraclonidine 2个小时之后，该名女婴因嗜睡和无应答性，以及心搏过慢（每分钟84下）、呼吸浅弱（每分钟40次）以及血压115/85 mm Hg等症候而被送进急诊室；血氧饱和度原先为80%，在面罩给氧后迅速回复到100%，在使用apraclonidine 8个小时后，该名女婴终於回复健康状态。

"Apraclonidine, a selective alpha-2-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine," write Patrick Watts, MBBS, MS, from the University Hospital of Wales in Cardiff, United Kingdom, and colleagues."An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil due to its alpha-1-effect on a pupil with denervation supersensitivity.... The easy availability of apraclonidine, its mild alpha-1-agonist activity, and its hitherto benign safety profile has encouraged its use as a first-line drug in the diagnosis of oculosympathetic paralysis."

英国加地夫市威尔斯大学附设医院的外科学硕士Patrick Watts及研究同仁指出，Apraclonidine是一种选择性的α-2-拮抗剂，是用来降低眼内压，并减少其母系药物降保适使用上的相关全身性副作用；在一项针对apraclonidine作用位置的研究中，因其单侧瞳孔神经切除之α-1-效应，而附带提出单侧瞳孔无交感神经支配患者之瞳孔大小不等为可逆转，apraclonidine之高可利用率，其轻微的α-1-拮抗活性，以及迄今良好的用药安全档案，更强化其作为视交感神经瘫痪诊断第一线药物的使用率。

Logistic regression analysis discovered that the symptoms correlate with outcome are consciousness,flushed cheeks,anisocoria,accelerated breathing,gruff breathing,fever,spontaneous perspiration,dry stool and foul breath.3 Electroencephalography monitoring22 patients were included and no patient\'s electroencephalogram was normal. Special types of electroencephalogram include 1 spindle coma and 3α,θcoma, and 1 patient\'s electroencephalogram appeared spike and slow wave complex.

Logistic回归分析显示神志、两颧潮红、瞳孔不等、呼吸急促、呼吸气粗、发热、自汗、便于、口臭与结局相关。3.3脑电监测结果共纳入患者22例，生存组和死亡组患者无1例正常脑电图表现，特殊类型脑电有1例纺锤波昏迷，3例α、θ昏迷，1例出现棘慢复合波。

Poor consciousness,flushed cheeks,anisocoria,accelerated breathing and fever indicate poor short-term prognosis while gruff breathing,foul breath, spontaneous perspiration,dry stool indicate good short-term prognosis.

其神志差、两颧潮红、瞳孔不等、呼吸急促、发热预示差的近期预后，呼吸气粗、口臭、自汗、便干提示近期预后较好。

Poor consciousness,flushed cheeks,anisocoria,accelerated breathing and fever indicate poor short-term prognosis while gruff breathing,foul breath, spontaneous perspiration,dry stool indicate good short-term prognosis.

其神志差、两颧潮红、瞳孔不等、呼吸急促、发热预示差的近期预后，呼(来源：7bABC论5f5f文网www.abclunwen.com)吸气粗、口臭、自汗、便干提示近期预后较好。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。