直至最后

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后，易感神经元会萎缩直至死亡，原因可能有兴奋性中毒（神经递质对神经元表面受体的过度刺激引起），钙稳态失衡，炎症反应，能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合，可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应，也可调节不同信号级联反应，这些级联反应对于维持神经元活动性和生存性意义重大。

The first gut reflux moves digesta from the gizzard back into the proventriculus once for each gastro-duodenal contraction cycle.

这种收缩循环会重复很多次，直至饲料粒径降到1毫米以下，最后通过向十二指肠括约肌转运物质的小缝离开肌胃。

So we designed a adaptive synchronizing controller based on hereinbefore hardware environment: first a small magnitude reference signal r is outputted to system through the signal card (to ensure that the vibrating system works in a linear state), and this signal is sent to the moving coil of vibrator through the power amplifier, so vibration is produced through electromagnetic induction. Secondly the vibration signal can feedback to the data acquiring card in the servo system through the acceleration sensor on the Vibroseis reactor M〓 and the base-plate M〓, then the computer can get the current vibrating state y〓 of the coil of vibrator according to the feedback information from the data acquiring card, and give a real time comparing between the current state y〓 and the reference output y〓 of the set-in reference model with current reference input being r , then regulates the correlative controlling parameters according to the error e〓=y〓-y〓 till y〓→y〓, finally normal signal sweeping begins with a certain phase fixed. Meanwhile a synchronization signal for seismic signal record is sent to seismograph from synchronization signal outputting component in the Vibroseis system to perform the controlling process of synchronization of sweeping phases.

为此，我们基于以上的硬件环境设计了一个自适应同步控制器：首先通过信号发生卡对系统输出小幅度的参考信号r(从而保证振动系统工作处于线性状态)，信号通过前置放大器、功率放大器等送到激震器动圈，并通过电磁感应产生振动，振动信号通过可控震源激震器反应块M〓和基板M〓上的加速度传感器反馈给伺服系统中的数据采集卡，工控计算机根据采集卡的反馈信息，获取当前激震器动圈的振动状态y〓，并实时地将该状态与内置的参考模型在当前参考输入r下的参考输出y〓进行辨识，再将两者输出误差e〓＝y〓-y〓对系统的有关控制参数进行调整，直至y〓→y〓，最后在经过某一固定的相位后，开始信号的正常扫描过程，与此同时，由可控震源系统的同步信号输出部件向地震仪送出一地震信号记录同步信号，进而完成扫描相位同步控制过程。

I will compress them within the narrowest compass they will bear, staling the general principle, but not all its limitations. Equal and exact justice to all men, of whatever state or persuasion, religious or political; peace, commerce, and honest friendship with all nations, entangling alliances with none; the support of the State governments in all their rights, as the most competent administrations for our domestic concerns and the surest bulwarks against antirepublican tendencies; the preservation of the General Government in its whole constitutional vigor, as the sheet anchor of our peace at home and safety abroad; a jealous care of the right of election by the people--a mild and safe corrective of abuses which are lopped by the sword of revolution where peaceable remedies are unprovided; absolute acquiescence in the decisions of the majority, the vital principle of republics, from which is no appeal but to force, the vital principle and immediate parent of despotism; a well-disciplined militia, our best reliance in peace and for the first moments of war, till regulars may relieve them; the supremacy of the civil over the military authority; economy in the public expense, that labor may be lightly burthened; the honest payment of our debts and sacred preservation of the public faith; encouragement of agriculture, and of commerce as its handmaid; the diffusion of information and arraignment of all abuses at the bar of the public reason; freedom of religion; freedom of the press, and freedom of person under the protection of the habeas corpus, and trial by juries impartially selected.

我打算尽量简略地加以陈述，只讲一般原则，而不讲其全部范畴：不管人们的地位、宗教信仰或政治主张有何不同，人人都应得到平等和绝对公正的待遇；与所有国家和平相处，互相通商，并保持诚挚的友谊，但不与任何国家结盟，以免纠缠不清；维护各州政府的一切权利，使它们成为处理我们内政最合适的机构，以及抵制反共和趋势的最有力的屏障；维护全国的政府，使之能充分行使宪法赋予的权力，从而成为对内和平和对外安全的最后堡垒；要十分注意维护人民的选举权，因为革命留下的弊端，一时没有和平的补救办法，而人民选举权乃是对那些弊端的一种温和而安全的矫正手段；要绝对服从多数的决定，这是共和政体的主要原则，离开这个原则，便只好诉诸武力，而这就是专制的主要原则和直接起源；要维持一支纪律严明的民团，以作为和平时期和战争初期的最好依仗，直至正规军来接替；实行文权高於军校的政制；节省政府开支，减轻劳动人民的负担；如实偿还我们的债务，把维护政府的信用看作神圣的义务；促进农业发展，并鼓励以商辅农；传播知识并以公众理智为依据谴责一切弊端；保障宗教自由及出版自由，并以人身保护令以及由公平选出的陪审团进行审判来保障人身自由。

Pan-grill a slice of sourdough bread until toasted, drizzle with olive oil and cover with melted dark chocolate.

用平底锅烤一片面包直至烘热，洒上些橄榄油，最后抹上融化了的纯巧克力。

Lastly , pull the lower corner up to tuck it under baby s chin to complete a secure swaddle .

最后，拉较低的角落，直至塔克下婴儿的下巴完成一个安全的襁褓。

My last long termer, an Audi Allroad, didn't need its first service until 19,000 miles thanks to Audi's variable servicing schedule.

我最后的长期服刑，奥迪Allroad ，没有必要的服务，直至其第一一点九○○万英里感谢奥迪的可变服务时间表。

It was not till the last shred of pale Turkish tobacco had been consumed, and the grey ashes knocked out upon the topmost bar of the grate, that this pleasant dream floated off into the great storehouse in which the visions of things that never have been and never are to be, are kept locked and guarded by some stern enchanter, who only turns the keys now and then and opens the door of his treasure-house a little way for the brief deight of mankind.

直至灰白色土耳其烟草的最后一小撮也消耗殆尽，在炉栅最高的铁条上把灰白的烟灰从烟斗里敲了出来，这令人愉悦的美梦才飘浮到那最伟大的仓库里去了；世间从来不曾有过、将来也不会有的事物的幻象，都上了锁藏在这大仓库里，由某个严格的巫师守卫着，只是不时转动钥匙，稍稍打开一点儿仓库的门，让人类享有片刻的喜悦。

Usually, when peole have nothing to do, they will think a lot, something like a day dream,and I'm also of them. I'm an ordinary people, a worldling. I spent a lot of time to dream, and it's blind and dull. I can not reconigze myself a little bit. This's not what I used to be- very healthy, happy, optimistic, and full of energy. I know that I cannot keep going like this. If I continue doing this, my life will have nowhere to run, and then, I will slowly fall into depression till the day I will be destroyed."No, no way." I warned myself again and again,"get the confident I used to have and try my best to live." Although it maybe in vain, I have to try , to change my situation, to live better, untill I can be a sunny guy again.

人在无事可做的时候，是很容易胡思乱想的，我也不例外，我也是凡人，更是个俗人，大把的时间里不断的胡思乱想着，盲目又无聊，我有点不认识我自己了，这已经不是曾经的那个健康、快乐、积极、充满活力的我了，我不能再继续这样了，在这样下去我的人生将变得无路可逃，我也终究会慢慢的消沉下去，直至毁灭，不能，绝对不能，一次次的告诫自己，要拿出曾经的勇气来努力的好好生活，即使再徒劳，也要作出最后的努力，改变现状，好好生活，直到做回曾经那个阳光的我！

I will compress them within the narrowest compass they will bear, staling the general principle, but not all its limitations. Equal and exact justice to all men, of whatever state or persuasion, religious or political; peace, commerce, and honest friendship with all nations, entangling alliances with none; the support of the State governments in all their rights, as the most competent administrations for our domestic concerns and the surest bulwarks against antirepublican tendencies; the preservation of the General Government in its whole constitutional vigor, as the sheet anchor of our peace at home and safety abroad; a jealous care of the right of election by the people--a mild and safe corrective of abuses which are lopped by the sword of revolution where peaceable remedies are unprovided; absolute acquiescence in the decisions of the majority, the vital principle of republics, from which is no appeal but to force, the vital principle and immediate parent of despotism; a well-disciplined militia, our best reliance in peace and for the first moments of war, till regulars may relieve them; the supremacy of the civil over the military authority; economy in the public expense, that labor may be lightly burthened; the honest payment of our debts and sacred preservation of the public faith; encouragement of agriculture, and of commerce as its handmaid; the diffusion of information and arraignment of all abuses at the bar of the public reason; freedom of religion; freedom of the press, and freedom of person under the protection of the habeas corpus, and trial by juries impartially selected.

我打算尽量简略地加以陈述，只讲一般原则，而不讲其全部范畴：不管人们的地位、宗教信仰或政治主张有何不同，人人都应得到平等和绝对公正的待遇；与所有国家和平相处，互相通商，并保持诚挚的友谊，但不与任何国家结盟，以免纠缠不清；维护各州政府的一切权利，使它们成爲处理我们内政最合适的机构，以及抵制反共和趋势的最有力的屏障；维护全国的政府，使之能充分行使宪法赋予的权力，从而成爲对内和平和对外安全的最后堡垒；要十分注意维护人民的选举权，因爲革命留下的弊端，一时没有和平的补救办法，而人民选举权乃是对那些弊端的一种温和而安全的矫正手段；要绝对服从多数的决定，这是共和政体的主要原则，离开这个原则，便只好诉诸武力，而这就是专制的主要原则和直接起源；要维持一支纪律严明的民团，以作爲和平时期和战争初期的最好依仗，直至正规军来接替；实行文权高于军校的政制；节省政府开支，减轻劳动人民的负担；如实偿还我们的债务，把维护政府的信用看作神圣的义务；促进农业发展，并鼓励以商辅农；传播知识并以公衆理智爲依据谴责一切弊端；保障宗教自由及出版自由，并以人身保护令以及由公平选出的陪审团进行审判来保障人身自由。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。