盐酸化的

In the process of laboratory study, oxycodone was prepared by oxidating thebaine at 6,14-position under oxydol, hydrodeoxidizing 7,8-position double bond and 14-position ether under palladium catalyst. Furthermore, N-methyl of oxycodone was isolated byα-chloro-ethyl chloroformate under anhydrous condition and protection of 14-position hydroxyl to obtain noroxycodone, which was further converted into methylnaltrexone by N-alkylation in presence of cyclopropyl bromomethane, then by isolating 3-position methyl of methylnaltrexone under boron tribromide, becoming hydrochloride to prepare target compound, natrexone hydrochloride.

实验室工艺方面，本文首先用双氧水氧化蒂巴因的6-位和14-位、在钯炭催化下加氢还原7-8位双键和14-位醚合成羟考酮，然后提出并优化了在无水和14-位保护的情况下，用氯甲酸-α-氯乙酯脱去羟考酮的N-位甲基合成去甲羟考酮，再用环丙甲基溴将去甲羟考酮的N-位烷基化合成甲基纳曲酮，最后采用三溴化硼脱去甲基纳曲酮的3-位甲基和成盐酸盐合成盐酸纳曲酮。

The molar ratio of sulfate ions to carboxylate ions is determined by conductometric titration method and the molecular weight is tested by high performance gel permeation chromatography. The precision of these two methods is also studied. To improve the detection sensitivity, guanidine hydrochloride is used as the best derivation reagent of 911. A systematic research is done on the optimum derivatization condition of 911 and Guanidine hydrochloride. The M /G ratio of 911 has direct relation to its biological activity.

论文首先对911的基本理化性质进行了系统的分析，以电导滴定法和高效凝胶渗透色谱法分别测定了分子中硫酸根羧酸根的比值和911的分子量，并探讨了两种分析方法的精密度。911分子没有紫外吸收，为提高检测灵敏度，本文采用荧光标记法，通过对三种荧光试剂与几种寡糖和多糖衍生效果的综合比较，最终确定了盐酸胍为最佳衍生试剂，并以911为代表详细探讨了衍生化反应的最优条件。911糖链结构与褐藻胶主链结构类似，以甘露糖醛酸和古罗糖醛酸的嵌段形式存在，分子中M/G比值与911的物理化学性质和生物活性有直接关系。

The chemistry behavior research of wollastonite indicated that the silicon-potassium fertilizer has a chemical active in organic acid.The factors affecting manurial effect of silicon-potassium fertilizer are not only soil pH and desilicification,but also content and type of organ in the soil.Wollastonite chemistry behavior indicates that silicic acid can be dissolved out from silicon-potassium fertilizer in chlorhydric acid solution if pH of solution is not smaller than 2. The drop of apparent density,increase of DBP sorptive rate and specific surface for leavings indicate that hydrated silicon oxide is polyporous,and those mineralogic feature presignify that silicon-potassium fertilizer has a role of conservation of both Moisture and Fertility and improving soil structure.After active ingredient releasing,silicon-potassium fertilizer leaves half the substance (non-active ingredient)in soil.

熟料单矿物在酸溶液中的化学行为研究表明，硅钾肥矿物在有机弱酸中的化学活性较好，影响硅钾肥肥效发挥的因素是土壤pH值和土壤的去硅化程度，还有土壤有机质的含量与种类；硅灰石在盐酸溶液中化学行为表明，在反应体系pH不小于2的情况下，硅钾肥矿物大量溶出硅酸根组分；溶解残余物表观密度降低、DBP吸着率和比表面积增加表明水合二氧化硅是以多孔形式存在，为硅钾肥具有保水保肥、改良土壤结构的提供了矿物学依据。

In the synthesis of 2,3,5-trichloropyridine, 2-aminopyridine was firstly chloridized to 2-amino-3, 5-dichloropyridine, and then sodium nitrite solution was added with the existence of hydrogen chloride to diazotize the 2-amino-3,5-dichloropyridine.

在2，3，5-三氯吡啶的合成上，首先通过对2-氨基吡啶的氯化生成2-氨基-3，5-二氯吡啶，然后再有盐酸存在条件下加亚硝酸钠溶液重氮化后，发生桑德迈尔反应生成2，3，5-三氯吡啶和3，5-二氯吡啶-2-酮的混合物，最后用氯化亚砜进行再次氯化，经处理得到产品2，3，5-三氯吡啶。

Using hydrochloric acid as a cheap catalyst,perfume methyl furoate was synthesized from methanol and furoic acid prepared from furfural,and was characterized by GC,IR and 1H-NMR.

从糠醛出发，由制备的糠酸和甲醇反应，在盐酸催化下，合成了香料糠酸甲酯，并用IR、1HNMR、GC等进行了表征；探讨了包括高纯度糠酸的制备在内的反应影响因素，在醇酸物质的量之比为 5∶1、催化剂体积占甲醇体积 13.0 %、反应时间 3h的最佳工艺条件下，酯化收率为81 0 %，收率比硫酸法、某些固体超强酸法

The famciclovir was synthesized from purine by a series of steps by Acylation, Decarboxylation, Reduction ,and so on; Derivatives of these intermediates is described from the 6-chloro- 9H- purin-2-amine as raw materials in different conditions when the iodine and bromide were synthesized with the addition of two intermediate 6-bromo-9H-purin-2-amine and 6-iodo-9H-purin-2-amine; There is elaborated from the main part of a acetophenone, urineaminohydrochloride, phenylhydrazine, ethyl acetoacetate as raw material through a series of reactions to synthetic 3-phenyl-4-formylphenyl pyrazole and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-aldehyde two pyrazole aldehyde, and then with 2-amino-6-chlorine-9-(2-methicillin-oxo-co-methyl-4-yl) purine reaction of the two new pyrazole purine Schiff bases.

本论文主是采用以鸟嘌呤为原料，经过一系列的酰基化，脱羧，还原等反应作用下最终得到了产物2-氨基-9-(4-乙酰氧基-3-乙酰氧基甲基丁基)嘌呤；其中的中间体衍生物主要是阐述从以2-氨基-6-氯鸟嘌呤为原料通过在不同的条件下进行溴代与碘代分别合成了另外两种中间体2-氨基-6-溴鸟嘌呤及2-氨基-6-碘鸟嘌呤；还有一部分主要是阐述从以苯乙酮，盐酸氨基脲，苯肼，乙酰乙酸乙酯为原料通过一系列的反应先合成3-苯基-4-醛基吡唑及5-氯-3-甲基-1-苯基-1H-吡唑-4-甲醛这两个吡唑醛，然后再与2-氨基-6-氯-9-(2-甲氧羰基丁酸甲酯-4-基)嘌呤反应得到了两个新型的吡唑嘌呤席夫碱

The title compound used as an amino acetylating reagent was further reacted to yield Cefepime hydrochloric acid, the crystals obtained has white pale color and is stable to temperature, and has no E-isomer too.

用其作为氨基酰基化试剂进一步合成盐酸头孢吡肟，也得到基本上白色的对温度稳定的不含E-异构体的晶态化合物。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。