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In Chapter 3 and Chapter 4, this kinetic method was applied to the studies of inactivation kinetics of Chinese hamster dihydrofolate reductase by urea or guanidine hydrochloride.

在第三、四两章中,我们将酶活性不可逆抑制底物反应动力学理论应用于中华仓鼠二氢叶酸还原酶的脲和盐酸胍失活动力学研究。

Denaturation with guanidine hydrochloride or urea is one of the primary ways of measuring the conformational stability of proteins and comparing the stability of mutant proteins.

测定天然蛋白质和蛋白质突变体构象稳定性的一个基本方法是在盐酸胍或脲作用下进行蛋白质变性研究。

Except for unstable V66W102, the guanidine and thermal denaturation of fragments are cooperative and well approximated by the two-state transition.

除了不稳定的V66W102,其它片段的盐酸胍和热变性过程协同,符合二态模型。

To explore a unified mechanism of protein folding, the unfolding of pepsin induced by urea or guanidine hydrochloride has been studied by "phase diagram" method of fluorescence.

为了探索一个统-的蛋白质折迭机理,用荧光相图法分别对脲和盐酸胍诱导的胃蛋白酶的去折迭过程进行了研究。

OBJECTIVE To study the plasma protein binding rate of harmine hydrochloride.

目的:测定盐酸去氢骆驼蓬碱的血浆蛋白结合率。

The plasma concentrations of harmine hydrochloride were measured by reversed phase high performance liquid chromatography.

结果 :大鼠灌胃盐酸去氢骆驼蓬碱胶囊后血浆药物浓度在 0 2 3h左右达峰(2 95 8g·mL-1),消除半衰期为 5 33h ,灌胃胶囊剂的生物利用度为 19 6 5 %。

OBJECTIVE To provide biological pharmaceutical basis for dosage forms design of harmine hydrochloride by studying its absorption kinetics in various intestinal segments of rat.

目的 研究盐酸去氢骆驼蓬碱在大鼠胃肠道各段的吸收动力学特征,为其剂型设计提供生物药剂学依据。

Harmine hydrochloride was absorbed perfectly in the duodenum, jejunum, ileum, and colon.

结论盐酸去氢骆驼蓬碱在十二指肠、空肠、回肠及结肠中均能较好地吸收。

Harmine hydrochloride was encapsulated into liposomes by active loading method.

目的 制备高包封率的盐酸去氢骆驼蓬碱脂质体。

Results As the pH value increasing, the solubility of harmine hydrochloride was decreased, while the apparent oil-water distribution coefficient was increased.

结果 随pH值的增大,盐酸去氢骆驼蓬碱的溶解度降低,表观油水分配系数增大;采用主动载药法,包封率随脂质体内外相pH梯度的减少而降低,受孵育温度的影响不大,在药脂比小于1∶5时脂质体包封率达到80%以上。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。