皮霉菌病

This paper provided a statistical analysis of 2000 patients with allergicdiseases in Xi'an and the surrounding area.The results of the analysis show-edg:(1) the incidence of the allergic disease had little difference be-tween male and female, while it was higher in youth and children; respi-ratory allergy, skin allergy, and pollinosis were main types of the disea-ses;(2)the positive ratio of the skin tests of atopic inhalant allergenswas 66.4%,among which, mite, pollen, mold and house dust were high...

本文分析西安及其周围地区2000例变态反应病的情况，结果表明：两性发病率基本相同；青年期和儿童期为好发病期；过敏性呼吸道疾病、皮肤疾病及花粉症是主要发病类型；特异性吸入性过敏原皮试阳性率为66.4%，其中螨、花粉、霉菌的阳性率最高，室尘次之，是本地区过敏性疾病的主要过敏原；采用免疫治疗总有效率为90.15%，非特异性免疫调节治疗可增加免疫治疗效果。

Indications: for quick treatment of localized mycosis, dermatophytes, Athlete's foot, Candidiasis, Fungal Infection, Labial moniliasis, Vulvitis, genital, anal and peri-anal mushrooms, Erythrasma, Ingrown and nail Fungal infection

适应症：快速治疗局部霉菌病、皮霉菌、运动员脚、念珠菌、真菌皮肤感染、唇念珠菌病、外阴炎、生殖器、肛门及肛门周围蘑菇形增生。红藓，指甲长入肌肉以及指甲霉菌感染。

Among the patients, fungal infections were correlated with male gender and bedridden status while xerosis was associated with increasing age. For scabies infection, a previous history of scabies was the most significant statistical risk factor.

针对病患来看，统计上发现霉菌感染与男性性别及长期卧床相关，乾皮症与年龄相关，而疥疮感染的危险因子主要为过去的疥疮病史。

For individuals with suspected scabies or fungal infections, skin samples were collected, prepared by standard procedures, and then examined microscopically. Results: Fungal infections were found in 61.6% of nursing home patients, of which most (95.1%) were on the foot. 58.3% of patients were diagnosed with xerosis, mainly on the lower leg (94.0%).

结果：由临床诊断，发现61.6%的病患患有霉菌感染，其病灶多发生在跖部(95.1%)。58.3%的病患有乾皮症，但多集中在小腿(94.0%)，甲癣占病患总数57.3%，足癣34.4%，以及手癣11.6%。

MTT assay FAK signaling pathway inhibitor genistein on human corneal epithelial cell cytotoxicity;RT-PCR detection of human corneal epithelial cells adhesion to fungus at different times,extracellular matrix protein including laminin,fibronectin,FN glass,Ⅳcollagen,transmembrane protein integrinαⅤ,integrinβ1(ITGβ1),as well as the FAK signaling pathway FAK1,FAK2 and Paxillin gene expression;Western blot detection of the signal transduction pathway adhesion-associated protein ITGβ1,FAK and PAX expression and the inhibition of genistein. Immunocytochemical method was used to observe the LN,FN and FAK expression in human corneal epithelial cells during interaction with the fungues;Laser scanning confocal microscope had a cell positioning on FN,FAK and PAX,observed the changing of the human corneal epithelial cytoskeleton after stimulated by fungues;Quantitatived by flow cytometry to detect of human corneal epithelial cells with PAX at ITGβ1 fungal expression after adhesion;Optical microscopy quantitied the fungues and human corneal epithelial cell adhesion and recorded to determination the integral optical density afrer adhesion;Scanning and transmitted electron microscope observed the changing of cell ultrastructure after fungues and human corneal epithelial cell adhesion.

第一部分真菌激活人角膜上皮细胞FAK信号转导通路的体外实验研究将三种常见致病真菌(白色念珠菌、烟曲霉菌和茄病镰刀菌)分别与人角膜上皮细胞共孵育，MTT法检测FAK信号通路抑制剂染料木黄酮的对人角膜上皮细胞的细胞毒性作用；RT-PCR检测真菌黏附人角膜上皮细胞后不同时间细胞外基质层连蛋白、纤连蛋白、玻连蛋白、Ⅳ型胶原、跨膜蛋白整合素αV、整合素β1(ITGβ1)，以及FAK信号通路中FAK1、FAK2和桩蛋白基因的表达情况；Western blot的方法检测黏附信号转导途径相关蛋白ITGβ1、FAK和PAX的表达，以及染料木黄酮对真菌刺激人角膜上皮细胞FAK信息通路活化的抑制作用；免疫细胞化学方法观察人角膜上皮细胞与真菌相互作用过程中LN、FN和FAK的表达；激光共聚焦显微镜对FN、FAK和PAX进行了细胞定位，并观察真菌刺激后人角膜上皮细胞骨架的变化；流式细胞仪定量检测人角膜上皮细胞ITGβ1与PAX在真菌黏附后表达的改变；光学显微镜观察真菌与人角膜上皮细胞黏附数量，记录并测定了黏附后积分光密度值OD扫描及投射电镜观察了真菌与人角膜上皮细胞黏附后，细胞超微结构的改变。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失