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皮质激素

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Addison's disease, also known as hypoadrenocorticism, is a reduction of production of glucocorticoids and mineralocorticoids by the adrenal glands.

阿狄森氏病,又名肾上腺皮质功能减退,是肾上腺分泌的糖皮质激素和盐皮质激素减少。

DATA SYNTHESIS:① Under high altitude, the body would generate stress reaction to hypoxia, that is the adaptive action of hypothalamus-adenohypophyseal-adrenal cortical axis, and the increase in the concentration of adrenocorticotrophic hormone to regulate the adaptability of body to stress stimulation, moreover, to induce the increase in releasing factor secretion.

资料综合:①高海拔状态下机体对低氧产生应激反应,表现为下丘脑―垂体―肾上腺皮质轴的适应性运转,血中促肾上腺皮质激素浓度增加,以调节机体对应激刺激的适应能力,同时使促肾上腺皮质激素释放因子分泌增加。

To evaluate the effect of cold stress on hypothalamic-pituitary-adrenal HPA axis in chic-kens,15-day-old male Isa chickens were subjected to acute(for 15min,1h,3h,6h,12h and 24h,respectively) and chronic(for 5d,10d and 20d,respectively) cold stress at 12℃±1℃.The level of expression of corticotropin releasing hormone mRNA in hypothalami and the contents of adrenocorticotrophic hormone,aldosterone and cortisol in serum of the chickens were detected.

为探明冷应激对雏鸡下丘脑-垂体-肾上腺皮质轴的影响,对15日龄公雏鸡进行了急性(15min、1h、3h、6h、12h和24h)与慢性(5d、10d和20d)冷应激处理(12℃±1℃),检测了雏鸡下丘脑促肾上腺皮质激素释放激素mRNA的表达水平及血清促肾上腺皮质激素、醛固酮及皮质醇的含量。

The influencing factors of femoral necrosis included the degree of healing activity, the dosage summation of corticosteroids, and length of ictus therapy. The influencing factors of bone density included age, dosage summation, and length of ictus therapy. The influencing factors of the bone fabric and flexibility included the use and length of ictus therapy. Statistics showed that serum IgG was not related with avascular necrosis of femoral head and osteoporosis.

股骨头缺血性坏死的影响因素有后期活动量、糖皮质激素总量和糖皮质激素冲击疗法的持续天数;骨密度的影响因素有年龄、冲击疗法和糖皮质激素总量;骨结构和骨弹性的影响因素有冲击疗法、冲击疗法持续的天数;血清抗体IgG与患者康复期股骨头缺血性坏死、骨质疏松在统计学上无联系。

Results: 1.Empirical study: The changes of learning and memory performances and hippocampal morphology were related to ageing. Both short-term and long-term administration of excessive glucocorticoids induced the decrease of learning and memory performances and hippocampal neurodegeneration. Adrenalectomy operated during both infancy and senectitude inhibited the hippocampal structure and function.

结果:1、实验研究:动物学习记忆能力及海马的形态与增龄密切相关,短期、长期给予过量糖皮质激素可造成海马退行性改变和学习记忆功能的降低,幼年期糖皮质激素剥夺可影响动物神经发育和功能,老年期长期糖皮质激素剥夺可加重动物海马退行性病变和学习记忆能力下降。

The regulation of estrogen on irrational attacks mainly in the following categories : testosterone, cortisol.adrenocorticotropic hormone and adrenocorticotropic hormone, etc..

激素对非理性攻击行为的调节主要集中于以下几种:睾丸酮、皮质醇、肾上腺皮质激素和促肾上腺皮质激素等。

Conditions in which mineralcorticoid excess occurs include Cushing syndrome, primary hyperaldosteronism, and adrenocorticotropic hormone-secreting tumor s.

皮质激素过多见于库欣综合征、原发性皮质激素增高症和促肾上腺皮质激素分泌性肿瘤。

To observe the change of behavior index and mensurate the contents of plasma CORT, CRH and ACTH by using radiation immunity methods, and observed the change of immunity function by testing IL-2 and lymphocyte multiplication produced by spleen cell. At the same time, the author examined the change of thalamencephalon CRH mRNA and pituitary ACTH mRNA.

观察行为学指标的变化,利用放免法测定血浆皮质酮、下丘脑促肾上腺皮质激素释放激素和血浆促肾上腺皮质激素的含量,并通过脾细胞产生白细胞介素2(IL-2)水平和淋巴细胞增殖试验观察大鼠免疫功能的变化,同时检测大鼠下丘脑CRH mRNA和垂体ACTHmRNA含量变化。

Glucocorticoids are effective in inducing apoptosis via the uncharacterized mechanisms in many hematological malignancies. GC-induced apoptosis is initiated by, and strictly dependent upon, the interaction of GC with its receptor, the GR.

皮质激素(glucocorticoid,GC)通过与其特异性受体-糖皮质激素受体(glucocorticoid receptor,GR)结合,不仅可诱导未成熟胸腺细胞凋亡,而且对急性白血病细胞、淋巴瘤细胞、骨髓瘤细胞等均有促凋亡作用,诱发凋亡正是应用糖皮质激素治疗白血病的分子生物学基础。

DATA SELECTION: Literatures about the comparison of bone density and bone metabolic change between inhaled GC group and control group were consorted deleting randomized controlled trial so as to look up the whole content of healthy controls;While patients in the treatment group received GC inhalation.

研究对象为服用糖皮质激素的成年男性和绝经前女性哮喘患者。资料选择:选取试验包括吸入糖皮质激素治疗组和对照组的骨密度、骨代谢变化比较的相关文献,进行初审,删除明显不随机临床试验的研究,然后查找余下的文献全文,进一步判断是否为 RCT。纳入标准:① RCT,无论是否为单盲、双盲或非盲法;②平行对照组,即未使用激素的哮喘患者或健康对照;治疗组为吸入激素的哮喘患者。

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