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Results Cortical tumors were seen in 9 cases, including adenomatous hyperplasia in 3 cases, adenoma in 4, cortical adenocarcinoma in 2;Medullary tumors were seen in 9 cases, including pheochromocytoma in 5 cases, metastasis in 3, neuroblastoma in 1;interstitial tumors were seen in 9 cases, including myelolipoma in 4 cases, and neurofibroma,cyst, lymphoma, malignant transformation of mesothelioma, malignant mesenchymal tumor in one, respectively.

结果 皮质肿瘤9例,其中肾上腺腺瘤样增生3例,腺瘤4例,皮质腺癌2例;髓质肿瘤9例,包括嗜铬细胞瘤5例,转移瘤3例,神经母细胞瘤1例;间质肿瘤9例,其中骨髓脂肪瘤4例,神经纤维瘤、囊肿、淋巴瘤、间皮瘤恶变、间叶组织来源恶性肿瘤各1例。

Histological structures of bursas of Fabricius were observed at the different developmental stages from chicken embryoes to chickens. The results were as follows. The bursa of Fabricius began to develop on the 13th day of post-hatching and its cell aggregated into the nodosity clique underneath the epithelium mucosae. On the 15th day of post-hatching, those cell cliques were surrounded by the flat epithelium and formed the basic structure of folliculus lymphaticus. The number of lymphocytes in the folliculus lymphaticus increased gradually, and the medulla and cortex of a majority of folliculus were not discriminated obviously. Until on the 7th day for chickens, the medulla and cortex of folliculus formed completely and the number of folliculus increased significantly. From 21 to 35 days old, the folliculus lymphaticus transformed from polygon into rectangle. Mucosa epithelial cells increased gradually and their cytoblasts arranged compactly into aline in the basilar part on the 35th day.

本研究观察了从鸡胚到出壳后的不同生长发育阶段法氏囊的组织结构,结果表明:胚胎13日龄时,法氏囊开始发育,粘膜上皮下形成结节状细胞集团;胚胎15日龄,聚集的细胞集团形成初始的淋巴滤泡;胚胎18日龄到出壳后1日龄,滤泡内淋巴细胞数量增多,多数滤泡髓质和皮质界限仍不明显;7日龄雏鸡法氏囊髓质皮质分界清晰,滤泡数量显著增多;21日龄到35日龄,滤泡由多边形逐渐转变成长方形;在35日龄时,粘膜上皮细胞逐渐增多,排列紧密,细胞核紧密排列成直线位于基底部。

ConclusionGR mRNA upregulation in lung tissue could be one of the mechanism of glucocorticoid's effective cure for pulmonary fibrosis,and GR mRNA downregulation in lung tissue in renalyang asthenia syndrome could be one of cause of glucocorticoid's noneffective therapy for pulmonary fibrosis,in addition,the Chinese traditional medicine with warming Yang effect could be effective therapy for pulmonary fibrosis.

结论肺组织GRmRNA表达的上调是糖皮质激素防治肺纤维化之所以有效的机理之一,而肾阳虚状态下肺纤维化肺组织GRmRNA表达下调是临床上许多肺纤维化病人对糖皮质激素不敏感的原因之一,同时,温阳药也极可能具有防治肺纤维化的作用。

Fas immunoreactivity could be seen in the cytoplasm and processes of Purkinje cells and in the brain stem nuclei, including vestibular nucleus, dorsal nucleus of vagus and spinal nucleus of trigeminal nerve.

大脑皮质各层可见FasL阳性神经细胞,以Ⅱ、Ⅴ层的锥体细胞阳性明显,Fas未见分布。小脑皮质的梨状细胞层的Pukinge细胞胞浆和突起呈Fas阳性反应,而FasL阳性神经元分布于小脑神经核。

Intensely and densely stained PKC_γimmunoreactive neurons were mainly observed in the cerebral cortex, hippocampus,amygdaloid complex,cerebellar cortex,ventral and dorsal cochlear nuclei,caudal spinal trigeminal nucleus and spinal dorsal horns.

研究发现PKCγ阳性神经元广泛分布于大鼠神经系统,密集、浓染的PKCγ阳性神经元主要见于大脑皮质、海马、杏仁复合体、小脑皮质、耳蜗腹侧核和耳蜗背侧核。

Objective:To explore the signaling transduction of CCK8 in mice neurons by proteomics methods.Methods:Cultured neurons were labled with [32P]orthophosphate (2.03×105Bq/ml) for 2h in 5%CO2 at 37℃. DMEM and CCK8 (10-7mol/L) were added to respectively for 0, 5, 20, 60 and 120min.

目的:通过应用蛋白质组学的方法与技术,对八肽胆囊收缩素(octapeptite cholecystokinin, CCK8)作用于乳小鼠皮质神经元后蛋白质磷酸化状态进行分析,为初步探讨胆囊收缩素在皮质神经元中的信号转导途径提供依据。

Results Sacroiliac joints in 62 cases were abnormal:in early stage,articular face was affected and the bone cortex incrassated and osteosclerosis partly,joint space was normal;in late stage,vermiform destruction of bone was seen in articular face,the density of cortex was heighten irregular,joint space widen or narrow,and at last the joint space vanished,the joint ankylosed.

结果 62例患者骶髂关节表现异常,包括:早期,骨关节面受侵蚀、骨皮质局限增厚、硬化,关节间隙正常;后期,关节面呈虫蚀状改变,关节面皮质密度不规则增高,关节间隙增宽或变窄,最终关节间隙消失,关节强直。

Brain injury in rat activated NF-κB for long time. During the first 1-2hours after injury, activated NF-κB existed mainly in axon, and then appeared inastrocyte in the next 24 hours, lasted for 1 year in pallium.

鼠脑损伤后可致NF-κB的长时间激活,创伤后1~2小时内,激活的NF-κB主要存在于轴突,在创伤24小时后激活的NF-κB主要存在于受伤皮质内的小神经细胞和星形胶质细胞内,这种激活可在脑皮质中至少持续1年。

Right hemisphere became obviously swelling and pale, the sign ofhemorrhage under cerebral pia mater is manifest, and the other side of the brain isnormal. The colors of whole brains were stained into rose pink with TTC.

电镜超微结构形态学观察:小脑皮质最先在HIBD 1h出现凋亡征象,其次为大脑皮质在HIBD 12h、海马CA1区在HIBD 24h出现凋亡细胞超微结构明显改变,随损伤时程进展各部位细胞超微结构改变明显,细胞器损伤加重。

Corticoadrenal hormone treatment of CAH should select different kind of corticoadrenal medicine for different kind of CAH. Treatment of sex hormones is not suitable for children suffered from 17 hydroxylase dificincy until prepuberty.

先天性肾上腺皮质增生应根据疾病类型而选用不同皮质激素进行治疗,对于17α羟化酶缺乏的病例,儿童期至青春期不宜应用性激素治疗。

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