皮血管炎

Of the many clinical symptoms, the frequently seen are seborrheic dermatitis, proliferation of blood vessels around cornea, cheilitis, corners of mouth look wet, white, thicker than usual, black and blue with swelling, nipple hypertrophy or atrophy, and often complicated by scrotal dermatitis.

维生素B2缺乏病临床症状较多，常见的有脂溢性皮炎、角膜周围血管增生、唇炎、口角湿白增厚、青红肿、乳头肥大或萎缩，常并发有阴囊皮炎。

The clinical observation suggested that YAG lasers did well in coagulation and charring of blood vessel;MEO did well in improving the growth of epithelium mucosa in the burned surface,and did well in anti-inflammation and styptic.

通过临床观察，YAG激光凝固、炭化血管效果较好，MBO可促进创面粘膜上皮生长、止痛消炎，二者联合应用，增强了治疗效果，缩短了治疗时间，复发率低，患者痛苦小。

The results showed that the contents of glutamic-pyruvic transaminase and glutamic oxaloacetic transaminase in part of the dogs were high and spontaneous pathologic changes occurred in the important organs, such as lung, kidney and brain. The incidences of interstitial pneumonia, cerebral ependymitis and vascular infiltration were high. Cloudy swelling and vasular degeneration appeared in part of hepatocytes and epithelial cells of renal tubules.

实验结果为部分犬的肝功能谷丙转氨酶和谷草转氨酶偏高；肝、肺、肾和大脑等重要脏器有自发性病理改变；肺的间质性肺炎和大脑室管膜炎及血管围管性浸润发生率较高，部分肝细胞和肾小管上皮细胞呈现浊肿或空泡变等。

Mirror infiltrating the cancer vagina the image is that the blood vessel is abnormal mainly,original place cancer vagina mirror visible image acetic acid white epithellum,major partners the shape blood vessei,heterotype blood vessel,mosaic and floccosoids wait a little bit;CIN acetic acid white maximum appears on epithelium,the shape blood vessel,heterotype blood vessel,rnosaic and floccosoids take second place;The chronic cervicitis gives first place to no representative shape blood vessel China and acetic acid white epithelium.

浸润癌阴道镜图像主要是血管异常，原位癌阴道镜图像可见醋酸白色上皮，多数伴有点状血管、异型血管、镶嵌和白斑等；CIN醋酸白色上皮出现最多，点状血管、异型血管、镶嵌和白斑次之；慢性宫颈炎以不典型点状血管和醋酸白色上皮为主。

Mirror infiltrating the cancer vagina the image is that the blood vessel is abnormal mainly,original place cancer vagina mirror visible image acetic acid white epithellum,major partners the shape blood vessei,heterotype blood vessel,mosaic and floccosoids wait a little bit;CIN acetic acid white maximum appears on epithelium,the shape blood vessel,heterotype blood vessel,rnosaic and floccosoids take second place;The chronic cervicitis gives first place to no representative shape blood vessel China and acetic acid white epithelium.

浸润癌阴道镜图像主要是血管异常，原位癌阴道镜图像可见醋酸白色上皮，伴有点状血管、异型血管、镶嵌和白斑等；CIN醋酸白色上皮出现最多，点状血管、异型血管、镶嵌和白斑次之；慢性宫颈炎以不典型点状血管和醋酸白色上皮为主。

Numerous case reports featuring its off-label use suggest the drug could be helpful in treating hidradenitis suppurativa, pyoderma gangrenosum, Sweet's syndrome, cutaneous sarcoidosis, pemphigus, systemic vasculitides, multicentric reticulohistiocytosis and stomatitis.

许多以非常规用药为特色的病例报告指出，该药物有助于治疗化脓性汗腺炎、坏疽性脓皮病、Sweet综合征、表皮结节病、天疱疮、系统性血管炎、多中心网状组织细胞增多症和口腔炎。

Results Among 4913 TRUST tests,57 occur the biological false positive reactions,the most occur the lepra,about 31.82% of the lepra patients,secondly RA 17.78%;systemic LE 17.02%,hepatitis 5.43%,scleroderma 3.33%,dermatomyositis 3.13%,activity tuberculosis 1.82%.

结果 4913例TRUST试验，57例发生生物学假阳性反应，麻风发生率最高，占麻风病例的31.82%，依次为类风湿关节炎17.78%，系统性红斑狼疮17.02%，变应性血管炎6.67%，乙型肝炎5.43%，硬皮病3.33%，皮肌炎3.13%，活动性肺结核1.82%，孕妇0.68%，正常人0.08%。

Results Among 4913 TRUST tests,57 occur the biological false positive reactions,the most occur the lepra,about 31.82% of the lepra patients,secondly RA 17.78%;systemic LE 17.02%,hepatitis 5.43%,scleroderma 3.33%,dermatomyositis 3.13%,activity tuberculosis 1.82%.

结果 4913例TRUST试验，57例发生生物学假阳性反应，麻风发生率最高，占麻风病例的31.82%，依次类风湿关节炎17.78%，系统性红斑狼疮17.02%，变应性血管炎6.67%，乙型肝炎5.43%，硬皮病3.33%，皮肌炎3.13%，活动性肺结核1.82%，孕妇0.68%，正常人0.08%。

In this review data on the use of rituximab is presented from 92 studies involving 1197 patients with the following diseases: systemic lupus erythematosus, idiopathic thrombocytopenic purpura, anti-neutrophil cytoplasmic antibody associated vasculitis, Grave's disease, autoimmune hemolytic anemia, pemphigus vulgaris, hemophilia A, cold agglutinin disease, Sjogren's syndrome, graft vs. host disease, thrombotic thrombocytopenic purpura, cryoglobulinemia, IgM mediated neuropathy, multiple sclerosis, neuromyelitis optica, idiopathic membranous nephropathy, dermatomyositis, and opsoclonus myoclonus.

本综述资料总结了92项共1197例患者应用利妥昔的研究，包括系统性红斑狼疮、特发性血栓性血小板减少性紫癜，抗中性粒细胞抗体相关性血管炎、甲状腺功能亢进、自身免疫性溶血性贫血、寻常型天疱疮、甲型血友病、冷凝集素病、干燥综合征、移植抗宿主疾病、血栓性血小板减少性紫癜、IgM介导性神经病、多发性硬化、视神经脊髓炎、特发性膜性肾病、皮肌炎和眼肌阵挛性肌阵挛。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。