皮埃尔拉特

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

The monasteries of Italy were suppressed by the Piedmontese in 1866, during the generalship of Raffaello Lippi of Ponticulo (1862-69) and in 1873 their fate was shared by the houses of the previously immune Roman province.

该寺院的镇压意大利的皮埃蒙特在1866年，在将军的拉斐尔里皮的Ponticulo （ 1862年至1869年），并於1873年他们的命运是共同的房子以前免疫罗马省。

The All-Star Game kicks-off at 21.30, with two sides consisting of Demetrio Albertini, Franco Baresi, Luca Cassol, Augusto De Megni, Mario Fargetta, Fabrizio Fontana, Franz, Gene Gnocchi, Mario Ielpo, Max Pisu and Valerio Staffelli on one side and Max Biaggi, Simone Braglia, Fabio Caressa, Claudio Coldebella, Maurizio Ganz, Leonardo, Paolo Ligresti, Marco Nosotti, Eros Ramazzotti, Ringo and Corrado Tedeschi on the other.

全明星赛将在21：30开始，两队球员包括了：阿尔贝蒂尼，巴雷西，卡索尔，迪。梅格尼，法格塔，丰塔纳，格诺奇，埃尔波，皮索以及斯特费里一队，另一队球员是，比亚吉，布拉格里亚，卡雷萨，寇德贝拉，冈茨，莱昂那多，里格雷斯特，诺索蒂，拉玛佐蒂，凌古和特德斯奇。

We're here to memorialize 29 Americans: Carl Acord. Jason Atkins. Christopher Bell. Gregory Steven Brock. Kenneth Allan Chapman. Robert Clark. Charles Timothy Davis. Cory Davis. Michael Lee Elswick. William I. Griffith. Steven Harrah. Edward Dean Jones. Richard K. Lane. William Roosevelt Lynch. Nicholas Darrell McCroskey. Joe Marcum. Ronald Lee Maynor. James E. Mooney. Adam Keith Morgan. Rex L. Mullins. Joshua S. Napper. Howard D. Payne. Dillard Earl Persinger. Joel R. Price. Deward Scott. Gary Quarles. Grover Dale Skeens. Benny Willingham. And Ricky Workman.

杂谈我们在这里，怀念29位美国人：卡尔·阿克德、杰森·阿金斯、克里斯多佛·贝尔、格利高里·布洛克、肯尼斯·查普曼、罗伯特·克拉克、查尔斯·蒂莫西·戴维斯、克里·戴维斯、迈克尔·埃尔斯维克、威廉·格里菲斯、史蒂芬·哈拉、爱德华·琼斯、理查德·雷恩、威廉姆·林奇、尼古拉斯·麦考斯基、乔·马克姆、罗纳德·梅尔、詹姆斯·姆尼、亚当·摩根、雷克斯·姆林斯、乔什·纳皮尔、霍华德·佩恩、迪拉德·波辛格、乔尔·普莱斯、迪华德·斯科特、加里·考拉斯、格罗佛·斯金斯、本尼·威灵汉姆、里奇·沃克曼。

Also present were John Elkann, Michel Platini, Giampiero Boniperti, Franzo Grande Stevens, Jean-Claude Blanc and the board of directors, Roberto Bettega, sport and political institutions, representatives from that year's team namely Bonini, Brio, Briaschi, Tacconi and Vignola as well as Alessandro Del Piero, Mariella Scirea, Giovanni Cobolli Gigli, Francesco Morini and Giuseppe Furino.

同样出席的还有约翰。埃尔坎、米歇尔。普拉蒂尼、博尼佩尔蒂、斯蒂文斯、布兰科以及各位董事会成员、贝特加、体育和政治组织、那一年球队中的代表Bonini、Brio、Briaschi、Tacconi和Vignola，还有亚历山德罗。德尔。皮耶罗、玛丽亚拉。西雷阿、吉利、莫里尼和朱塞佩。

Also present were John Elkann, Michel Platini, Giampiero Boniperti, Franzo Grande Stevens, Jean-Claude Blanc and the board of directors, Roberto Bettega, sport and political institutions, representatives from that year's team namely Bonini, Brio, Briaschi, Tacconi and Vignola as well as Alessandro Del Piero, Mariella Scirea, Giovanni Cobolli Gigli, Francesco Morini and Giuseppe Furino.

同样出席的还有约翰·埃尔坎、米歇尔·普拉蒂尼、博尼佩尔蒂、斯蒂文斯、布兰科以及各位董事会成员、贝特加、体育和政治组织、那一年球队中的代表Bonini、Brio、Briaschi、Tacconi和Vignola，还有亚历山德罗·德尔·皮耶罗、玛丽亚拉·西雷阿、吉利、莫里尼和朱塞佩·弗里诺。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。