皮内性的

Small intestinal biopsies showed subepithelial collagen deposition with varying degrees of villous atrophy and varying numbers of intraepithelial lymphocytes. Four patients had previous biopsies showing enteropathic changes without collagen deposition. Seven cases were associated with collagenous colitis and 1 also had features of lymphocytic colitis. Three patients also had collagen deposition in gastric biopsies. One case was associated with lymphocytic gastritis. Celiac disease (CD, gluten-sensitive enteropathy) was documented in 4 patients. Five patients made a clinical improvement with combinations of a gluten-free diet and immunosuppressive therapy. Two patients died of complications of malnutrition and 1 of another illness. Clonal T-cell populations were identified in 5 of 6 cases tested. Four of these patients improved clinically after treatment but 1 has died. Collagenous sprue evolved on a background of CD in 4 cases. There was no history of CD in others and these cases may be the result of a biologic insult other than gluten sensitivity.

小肠活检表现为上皮下胶原沉积，绒毛萎缩程度不一，上皮内淋巴细胞浸润数量不等。4例患者以往曾做过活检，表现为其他肠病改变，并没有胶原沉积。7例患者合并胶原性结肠炎，且1例还有淋巴细胞性结肠炎的特征。3例患者胃活检也发现有胶原沉积。1例患者合并淋巴细胞性胃炎。4例患者有乳糜泻（CD，谷蛋白敏感性肠病）病史。5例患者经无麸质饮食和免疫抑制治疗后，临床症状有所改善。2例患者因营养不良合并另一种疾病而死亡。6例患者做了T细胞受体基因重排，其中5例发现有克隆性T细胞群，这5例中有4例治疗后临床症状加重，且1例死亡。4例患者在CD的基础上病发胶原性口炎性腹泻；其余患者无CD病史，他们的发病也许是生物源性损害，而非谷蛋白敏感。

Objective To investigate the effect of all-trans retinoic acid on the change in intracellular glycogen in ovarian epithelioma cell line in vitro and ovarian epithelial carcinoma in nude mice in vivo.

目的 探讨全反式维甲酸干预后卵巢癌细胞株及裸鼠卵巢上皮性癌动物模型肿瘤细胞内糖原的变化及意义。

The distribution characteristics of primary neurons in skin referral area and gastric mucosa are that spinal ganglions present segmental distribution and superposing with each other,moreover,sympathetic ganglions present diffused distribution and have no segmental distribution,which may be the neural basis of treating visceral pain by intracutaneous- injection drug.

结论胃痛的皮肤牵涉区与胃黏膜初级神经元分布的特点是在脊神经节呈节段性分布且相互重叠，在交感神经节呈弥散性分布，无节段性分布，也相互重叠，这可能是皮内注药治疗内脏痛的神经基础。

The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients.

本发明涉及免疫原性组合物，其用于皮内输送与一种或多种赋形剂相组合的抗原性或免疫原性试剂。

In the present study, weclarify the capsaicin concentration dependency for developmentand maintenance of secondary mechanical allodynia and the roleof spinal opioid receptor like1 (ORL1) receptor and N -methyl-d-aspartatereceptor in the development and maintenance of secondary mechanicalallodynia induced by an intradermal capsaicin injection. Capsaicin50 L of 0.03% induced the most intense secondary mechanicalallodynia.

在这个实验中，作者研究皮内注射辣椒素与继发性机械性异常性疼痛的相关性和脊髓阿片受体相关1受体激动剂（ ORL1）和 N-甲基-D-天门冬氨酸受体在皮内注射引起的继发性机械性异常性疼痛的发生和维持中的作用。0.03%的辣椒素50uL 导致最强的异常性疼痛。

The nuclei were of low to intermediate nuclear grade with minimal nuclear pleomorphism. Thirteen of 17 cases (76%) were associated with conventional high-grade invasive urothelial carcinoma and 9 cases showed very focal intracytoplasmic vacuoles mimicking signet ring cells.

瘤细胞核的核级为低到中级，伴轻微的多形性。17例中有13例（76%）与常见的高度侵袭性的尿路上皮癌相关；有9例含灶性胞浆内空泡的瘤细胞，类似印戒细胞。

The stable clones are further identified by RT-PCR and Western blot; 6 MTT assay is used to investigate the effect of ZNRD1 on the cell growth of cells (AGS, SGC7901, MKN28, NIH3T3, GES-1); 7 Soft agar assay is used to investigate the effect of ZNRD1 on the clonality of cells (AGS, MKN28); 8 Nude mice assay is used to investigate the effect of ZNRD1 on the cell growth of gastric cancer cells (AGS, MKN28); 9 Flow cytometry is used to investigate the effect of ZNRD1 on the cell cycle distribution of cells (AGS, MKN28, NIH3T3, GES-1); 10 Flow cytometry is used to investigate the effect of ZNRD1 on the cell apoptosis of cells (AGS, MKN28, NIH3T3); 11 MTT assay is used to investigate the effect of ZNRD1 on the drug sensitivity of cancer cells (SGC7901, SGC7901/VCR, HL-60, HL-60/VCR) in vitro; 12 SRCA is used to investigate the effect of ZNRD1 on the drug sensitivity of gastric cancer cells (SGC7901, SGC7901/VCR) in vivo; 13 Flow cytometry is used to investigate the effect of ZNRD1 on adriamycin accumulation of cancer cells (SGC7901, SGC7901/VCR, HL-60, HL-60/VCR); 14 Transmission electron microscope is used to investigate the effect of ZNRD1 on the sensitivity of SGC7901 cells towards drug-induced apoptosis; 15 Flow cytometry and DNA ladder assay are used to investigate the effect of ZNRD1 on the sensitivity of cells (SGC7901, SGC7901/VCR, HL-60/VCR) towards drug-induced apoptosis; 16 Microarray is used to investigate the profiling of ZNRD1-responsive genes in gastric cancer cells (AGS, MKN28, SGC7901, SGC7901/VCR); 17 RT-PCR and Western blot are used to identify the results of microarray; 18 Reporter gene assay is used to investigate the effect of ZNRD1 on the transcriptional activity of cyclin D1; 19 Reporter gene assay is used to investigate the effect of ZNRD1 on the transcriptional activity of MDR1; 20 Kinase assay is used to investigate the effect of ZNRD1 on the activity of cyclin E-CDK2 kinase; 21 The antisensenucleic acids of p21 is used to inhibit the expression of p21, and flow cytometry is used to investigate the effect of p21 on ZNRD1-induced cell cycle arrest in gastric cancer cells; 22 The antisensenucleic acids of p27 is used to inhibit the expression of p27, and flow cytometry is used to investigate the effect of p27 on ZNRD1-induced cell cycle arrest in gastric cancer cells; 23 Liposome is used to up-regulate the expression of Skp2, and flow cytometry is used to investigate the effect of Skp2 on ZNRD1-induced cell cycle arrest in gastric cancer cells; 24 Western blot is used to investigate the effect of ZNRD1 on the stability of Skp2 and p27 in gastric cancer cells; 25 MVD assay is used to investigate the effect of ZNRD1 on the angiopoietic activity of gastric cancer cells; 26 ELISA is used to investigate the effect of ZNRD1 on the expression of VEGF165 in gastric cancer cells; 27 The roles of DARPP-32 in MDR of gastric cancer cells are investigated using gene transfection, MTT assay, SRCA, flow cytometry and DNA ladder assay.

应用杂交瘤技术制备ZNRD1的首个单克隆抗体；2）利用RT-PCR、Western blot和免疫组化检测ZNRD1在胃癌组织、胃炎组织、正常胃上皮组织、胃癌细胞和正常胃组织上皮细胞中的表达；3）构建ZNRD1的小干扰RNA载体，并测序鉴定；4）利用脂质体将ZNRD1的真核表达载体及其空载体转染胃癌细胞（AGS、SGC7901、MKN28）和小鼠成纤维细胞（NIH3T3），G418筛选后进行鉴定；5）利用脂质体将ZNRD1的小干扰RNA载体及其空载体转染药敏胃癌细胞（SGC7901）、正常胃组织上皮细胞（GES-1）、对长春新碱耐药的胃癌细胞（SGC7901/VCR）、药敏白血病细胞（HL-60）、对长春新碱耐药的白血病细胞（HL-60/VCR），G418筛选后进行鉴定；6）利用MTT实验检测ZNRD1高/低表达对细胞（AGS、SGC7901、MKN28、NIH3T3、GES-1）生长的影响；7）通过软琼脂克隆形成实验检测上调ZNRD1对AGS、MKN28细胞克隆形成能力的影响；8）通过裸鼠成瘤实验检测上调ZNRD1对AGS、MKN28细胞体内成瘤性的影响；9）通过流式细胞仪分析ZNRD1高/低表达对细胞（AGS、MKN28、NIH3T3、GES-1）的细胞周期的影响；10）通过流式细胞仪分析上调ZNRD1对细胞（AGS、MKN28、NIH3T3）的凋亡的影响；11）通过MTT实验检测ZNRD1高/低表达对细胞（SGC7901、SGC7901/VCR、HL-60、HL-60/VCR）体外药物敏感性的影响；12）通过肾包膜下移植法检测ZNRD1高/低表达对细胞（SGC7901、SGC7901/VCR）体内药物敏感性的影响；13）通过流式细胞仪分析ZNRD1高/低表达对细胞（SGC7901、SGC7901/VCR、HL-60、HL-60/VCR）内阿霉素蓄积和泵出的影响；14）通过透射电镜检测上调ZNRD1对SGC7901细胞凋亡敏感性的影响；15）通过流式细胞仪和DNA梯度试验检测ZNRD1高/低表达对细胞（SGC7901、SGC7901/VCR、HL-60）凋亡敏感性的影响；16）通过基因芯片检测ZNRD1高/低表达对胃癌细胞内基因表达谱的影响；17）利用RT-PCR、Western blot对基因芯片的结果进行鉴定；18）利用报告基因实验检测ZNRD1对cyclin D1的启动子活性的调节作用；19）利用报告基因实验检测ZNRD1高/低表达对MDR1的启动子活性的调节作用；20）利用激酶试验检测ZNRD1对cyclin E-CDK2 激酶活力的影响；21）利用反义核酸技术抑制p21的表达；通过流式细胞仪检测抑制p21对ZNRD1介导的细胞周期阻滞的影响；22）利用反义核酸技术抑制p27的表达；通过流式细胞仪检测抑制p27对ZNRD1介导的细胞周期阻滞的影响；23）利用脂质体转染法上调Skp2的表达；通过流式细胞仪检测上调Skp2对ZNRD1介导的细胞周期阻滞的影响；24）利用Western blot检测ZNRD1对p27和Skp2的蛋白稳定性的影响；25）利用微血管密度实验检测ZNRD1对AGS、MKN28细胞裸鼠移植瘤微血管形成的影响；26）利用ELISA检测ZNRD1对AGS、MKN28细胞培养上清和移植瘤匀浆中VEGF165含量的影响；27）利用脂质体转染法、MTT实验、肾包膜下移植法、流式细胞仪和DNA梯度试验检测新耐药相关分子DARPP-32对细胞（SGC7901、SGC7901/VCR、对阿霉素耐药的胃癌细胞SGC7901/ADR）多药耐药表型的影响；利用脂质体转染法和MTT实验检测下调ZNRD1对DARPP-32介导的胃癌多药耐药的调控作用。

This paper summarizes various structural models, structural belts, Cenozoic deformation frameworks and tectonic evolution concerning intraplate deformation in the West Kunlun - Pamir Cenozoic erogenic belt and Southwest Tarim foreland basin and suggests that the Cenozoic intraplate deformation be characterized by segmentation and stage evolution.

笔者总结了西昆仑—帕米尔造山带及塔西南前陆盆地板内变形的各类构造模式、构造分带、新生代变形格局及构造演化，提出其新生代板内变形具有弧形构造分段性和阶段性演化的特点，发现了依格孜牙、柯克亚、桑株—杜瓦、卡兹克—阿尔特薄皮弧形推覆构造、齐姆根主弧形构造段及玉力群—克里阳构造段的三角带构造及叶尔羌—棋盘对冲过渡型弧形构造。

Autosomal dominant polycystic kidney disease , one of the most common monogenetic human disorders, is characterized by the formation and progressive expansion of multiple cystic lesions, which compromise the function of normal renal parenchyma and lead to nearly 10％ of cases of end-stage renal failure in adults.

中文题名角质细胞生长因子在ADPKD肾囊肿组织中的表达及对囊肿衬里上皮细胞增殖作用的研究副题名外文题名 Expression of keratinocyte growth factor in ADPKD cystic tissue and effect of proliferation on ADPKD cyst-lining epitheliar cells 论文作者刘沙勤导师梅长林朱有华教授学科专业内科学研究领域\研究方向学位级别博士学位授予单位第二军医大学学位授予日期2002 论文页码总数104页关键词角质细胞生长因子肾病囊肿衬里上皮细胞株肾囊肿馆藏号BSLW /2003 /R692 /1 ADPKD是人类为之付出昂贵代价的一种全身性遗传性疾病，是引起慢性肾功能衰竭的第四位病因，在临床上以肾脏满布大小不一并不断增大的囊性液泡、最终引起肾功能进行性损害为特征性的改变。

These three internal fixations of femoral peritrochanteric fracture were differ. For example, Gamma nail is less harmful, better clinical treatment, shorter in shape and stronger in anti-hip inversion. DHS, DCS have a better treatment and are stronger in anti-hip inversion but more harmful and excessive bleeding, and HCS, which is named Minimally Invasive Surgery, is the least harmful, less bleeding, suitable for old patients and the patients of tolerance of poor operation, but poor in anti-hip inversion.

3种不同方法内固定治疗转子间骨折具有各自的特点，Gamma钉具有手术损伤小及良好的临床疗效力臂短对抗髋内翻的能力强；滑动加压鹅头钉具有良好的临床疗效及相对坚强的抗内翻能力，但手术损伤相对较大，失血量较大；空心加压螺钉固定的手术损伤最小，属于微创手术方法，可经皮完成，手术出血少，适用于高龄及手术耐受性差的患者，但抗髋内翻的能力最差。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。