白血病的

The study was aimed to investigate the mechanism of cytotoxic effect of trichosanthin on leukemia or lymphoma cell lines.

本研究的目的是探讨天花粉蛋白对人白血病和淋巴瘤细胞系的杀伤作用机制。

METHODS: We searched for abnormalities of the proapoptotic Bcl-x deamidation pathway in primary cells from patients with chronic myeloid leukemia or polycythemia vera, myeloproliferative disorders associated with the BCR-ABL fusion kinase and the Janus tyrosine kinase 2 (JAK2) V617F mutation, respectively.

我们分别对来自慢性粒细胞白血病或真性红细胞增多症、骨髓增生性疾病相关的BCR-ABL融合蛋白激酶及Janus酪氨酸激酶2 (JAK2) V617F突变体患者原代细胞凋亡前Bcl-x脱酰胺途径的异常情况进行研究。

Objective To investigate antitumor activity and molecular mechanism of deguelin to the human U937 leukaemia cells and to explore the mechanisms regulating cell cycle and nucleoporin 98 （Nup98） and nucleoporin 88 （Nup88） in vitro.

目的研究鱼藤素对人类白血病细胞株U937细胞体外抗肿瘤作用，研究其引起细胞周期与核孔蛋白Nup98和Nup88的改变，探讨其抗癌作用的分子机制。

Methods: Human T cell leukemia cell line Jurkat was chosen as a model. The effect of deguelin on the growth of Jurkat cells was studied by 3-(4,5-dimethyl-2-thiazolyl)-2,5 diphenyl-2H-tetrazolium assay. Apoptosis was detected through DNA fragmentation assay, Hoechst 33258 staining assay and Annexin V/PI double-labeled cytometry. The expression levels of nucleophosmin and nucleoporins, including Nup88 and Nup214, were studied by flow cytometry, Western Blot and reverse transcription-polymerase chain reaction.

以人类T淋巴细胞白血病细胞系Jurkat作为研究对象，采用MTT法检测细胞增殖活性；DNA ladder法、Hoechst33258染色法和Annexin V-FITC/PI双标法检测细胞凋亡；流式细胞术、Western Blot、RT-PCR检测鱼藤素作用前后，Jurkat细胞内核孔蛋白Nup88、Nup214与核磷蛋白(nucleophosmin， NPM)表达水平的变化；激光共聚焦显微技术观察上述核孔蛋白与核磷蛋白的亚细胞定位情况。

Objective To study the effects of diallyl trisulfide on proliferation, apoptosis and cell cycle in acute myeloid leukemia cells HL-60 and the probable mechanism involved, aiming at offering credible academic and experimental bases for clinical use.

目的：研究二烯丙基三硫对急性髓细胞系白血病细胞株HL-60细胞增殖、凋亡及细胞周期的影响并探讨其作用机制，为二烯丙基三硫用于临床防治癌症提供可靠的理论基础和实验依据。

Objective:To study the proliferation and expression of survivin protein in human leukemia HL-60 cell line treated with diallyl disulfide and to thus investigate the mechanism of DADS to inhibit HL-60 cells' growth.

目的：观察二烯丙基二硫(diallyl disulfide，DADS)作用于人白血病HL-60细胞株后，细胞增殖及survivin蛋白表达的变化，探讨DADS对HL-60细胞增殖的影响及其机制。

The therapeutic effect of recombinant vaccinia virus encoding human IL-2 gene(IL-2VV) on the tumor-bearing mice was investigated. The tumor-bearing mice were established by subcutaneus inoculation with 2×106 FBL-3 erythroblastic leukemia cells into C57BL/6 mice.

观察了编码人白细胞介素2(IL-2)基因的重组痘苗病毒(recombinant vaccinia virus encoding human IL-2 gene，IL-2VV)对小鼠接种FBL-3红白血病细胞诱发肿瘤的治疗作用。

Our previous researches have proved that matrine with certain concentrations may induce erythroid differentiation and apoptosis of K562 human leukemia cells and evidently influence the cell cycle and telomerase activity.

我们多年来的研究证明，苦参碱在体外可明显抑制人白血病细胞K562的增殖，诱导其向正常形态分化并显著影响细胞周期和端粒酶活性。

First, we observed the effects of extogenous IL-15 on Jurkat cells which express IL-15 receptors.

首先，我们观察了外源性IL-15对表达IL-15受体(IL-15R)的人类T细胞白血病细胞系Jurkat细胞的体外影响。

To explore the expressions of the intercellular adhesion molecule3（ICAM3） in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的 探讨细胞间粘附分子3(intercellular adhesion molecule3，ICAM3)在急性白血病（acute leukemia，AL）中的表达及其在临床疗效、髓外浸润中的意义。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。