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In these cases it is an indication of some injury or serious disease such as leukemia or sickle-cell anemia.

在这样的病例中,阴茎持续勃起症是某些损伤或严重疾病的征象,例如白血病或镰刀状红细胞贫血症。

Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis .

这样的脾肿大通常预示有骨髓增生型疾病,例如慢性髓性白血病或骨髓纤维化。你知道它的英文吗?

A patient's age, general health and subtype may play a role in determining the best treatment plan.

病人的年龄,健康状况,所患白血病亚型可在最佳治疗方案的确定中起作用。

Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.

在实验研究基础上,本研究进一步运用免疫沉淀和Western Blot印迹方法,检测AML患者原代细胞JAK2和STAT3活化情况,并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现,11例AML患者中,有3例呈现STAT3组成型活化(STAT3阳性,下同),无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性;在此3例患者中,1例未取得缓解,另外2例虽然取得短暂缓解,但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高,而凋亡率数值较低。

Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia

伴染色体 t(8;21)为特征的四倍体克隆的急性白血病二例

For instance, GCs are used to suppress immunity and treat lymphoid leukemia because they can induce apoptosis in thymocyte, leukemia cells and lymphocyte.

已知的如GCs能诱导胸腺细胞和淋巴细胞的凋亡,因此被临床用来抑制免疫功能和治疗淋巴细胞白血病。

She began by trying to see if she could unearth any environmental factor behind childhood leukemia, a tragic condition which unaccountably causes the death of many hundreds of UK children each year.

她首先希望看到她能发现任何环境因素是儿童白血病,一个悲惨的状况,莫名其妙死亡的原因很多数百名英国儿童每年。

Objective:To eveluate the value of monoclonal antibody in the classification of the acute leukemia unclassified by morphology.

目的:探讨单克隆抗体在形态学难以分型的急性白血病分型中的价值。

While CLL is a disease of elderly patients, subjects older than 65 years are heavily underrepresented in clinical trials.

虽然慢性淋巴细胞性白血病是一种发生于老年患者的疾病,临床试验中受试者在65岁以上的严重不足。

In 6 patients with chronic myeloid leukemia, all of them presented very high white blood cell counts (〉45 × 10^9/L) and represented completely wider and larger unimodal distribution of leukocyte histogram (100- 450 fl), among them 83.3 % cases were extremely higher (〉 100 × 10^9/L).

慢性粒细胞白血病患者白细胞总数均〉45 10^9/L,其中83.3%的患者白细胞总数异常增高(〉100 10^9/L),白细胞直方图均呈形状单一而分布广泛(100-450fl)的大细胞峰图形。

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