白血病的

Background and objective Although marked progress has been made in the treatment of acute myeloid leukemia,about 20%～40% patients with AML failed to get complete remission after standard induction chemotherapy. Furthmore, approximate 70% patients in CR will die because of relapse or refractory to therapy during post remission chemotherapy.

研究背景及目的：尽管目前急性髓系白血病(acute myeloid leukemia，AML)的治疗取得了显著的进步，但仍有20％～40％的患者经标准诱导治疗未能达到完全缓解(complete remission，CR)，即使获得CR的患者，在巩固化疗后仍有70％左右复发或发展为难治性急性髓系白血病而治疗无效死亡。

Low-flow priapism is a rare complication of leukemia resulting in hyperviscosity due to high leukocytes with leukostasis and is most frequently found in chronic myeloid leukemia.

低流量的阴茎异常勃起症为白血病罕见的并发症，是由於大量的白血球并白血球留滞而导致高黏稠性所造成的，最常见於慢性骨髓性白血病。

Subacut myeloid leukemia can be a defined type of leukemia. The common characteristics of subacute myeloid leukemia are as follows: the onset is insidious, and anemia and hemorrhage of skin and mucosa are the main clinical manifestations. Hepatosplenomegaly is rare. There are multilineage abnormalities in blood cell counts and increased blasts in the bone marrow with cytogenetical abnormal clone in most cases. The disease course is subacute and progressive.

1、亚急性髓性白血病是一个可以确定的白血病类型，其特征为：起病隐袭，以贫血或皮肤粘膜出血为主要症状，肝脾肿大的特征较少，血象为一系、二系或三系的异常，骨髓细胞形态学检查原早幼粒细胞异常增高，细胞遗传学检查多数有克隆性异常核型，病程中可有克隆演进，呈现亚急性而进行性的临床经过。

In vitro, studies demonstrated that new retinoids in combination with IFN-γ could induce monoblastic leukemia cells to differentiate and inhibit their proliferention.

本文研究了NB4细胞株和新鲜急性早幼粒白血病细胞在新维甲类R9158、R8923、R9123和YS904012作用后的生物学特性变化；并且在初筛的基础上，选用R9158和YS904012与IFN-γ联合使用，研究对U937细胞株和6例原代单核系白血病细胞的增殖分化作用。

Incontrast, berbamine had slight effect on normal bone marrow cells and its IC〓 value was 103.650± 10.257μg/ml which was 17.5-27.5 times higher than those of leukemic cells.

上述结果提示，小檗胺具有较广谱的抗白血病细胞的作用，白血病细胞对小檗胺的敏感性明显地高于正常骨髓单个核细胞。

Methods Sixty-six patients with hematological diseases （40 cases of acute leukemia, 24 chronic myeloid leukemia, and one each severe aplastie anemia and β-thalassemia） rceived bone marrow （ BMT, n = 48） or peripheral blood stem cell transplantation （ PBSCT, n = 18 ） from HLA-compatible unrelated donors after BUCY or TBI conditioning. Forty patients received longer and intensive GVHD prophylaxis （ cyclos- porin A from day - 10 combined with mycophenolate mofetil）.

方法慢性粒细胞白血病患者24例，急性白血病患者40例，其他血液病患者2例，经预处理治疗后，进行人类白细胞抗原基本相合的非血缘关系骨髓移植48例，外周血干细胞移植18例：部分患者采用长程加强的移植物抗宿主病的预防方案（将环孢菌素A提前至预处理开始时使用，同时加用霉酚酸酯）。

ES cells were maintained on gelatin-coated dishes in Iscove's modified Dulbecco medium containing 0.1 mmol/L of nonessential amino acids, 2 mmol/L of L-glutamine, 0.1 mmol/L of monothioglycerol, 15% fetal bovine serum, and 1000 U/mL leukemia inhibitory factor. Embryonic bodies were firstly formed by ES cells with hang drip method in IMDM without LIF. Six-day-old EBs were trypsinized and the cells were resuspended at a concentration of （3-4）×109 L-1 cells per 1 mL of a 1:1 mixture of culture medium and Matrigel?

实验方法：将鼠胚胎干细胞株接种于被覆明胶的培养瓶内，加入含0.1 mmol/L非必需氨基酸、2 mmol/L L-谷酰胺、0.1 mmol/L二羟基丙硫醇、15%胎牛血清、1 000 U/mL白血病抑制因子的IMDM培养液。3 d后采用&悬滴法&使细胞在不含白血病抑制因子的上述IMDM培养液中形成胚胎体，6 d后胰酶消化得到胚胎干细胞，浓度调整为（3~4）×109 L-1，与Matrigel？

Many childhood leukemias result from mutations called translocations, where gene pieces on chromosomes accidentally relocate and misalign. In infant leukemia, the chromosome containing the MLL gene breaks within MLL and ends up fused to a different gene.

很多儿童白血病是由一种被称为易位的基因突变（染色体上基因片断突然移位重排）引起的，在幼儿白血病中，含有MLL的染色体破损，然后融合到其它基因上。

To cooperate cure better, improve the life quality of patient of leukaemia of chronic bead cell, nurse commonly in executive internal medicine on groovy foundation, increase the standardization that suits patient of leukaemia of chronic bead cell to nurse content.

为了更好地配合治疗，提高慢性粒细胞白血病病人的生命质量，在执行内科一般护理常规的基础上，增加适合慢性粒细胞白血病病人的规范化护理内容。

Furthermore, the abnormality of PARP's activity and chromatin structure in leukemia cells was detected. Possible significance of this result was discussed.

在此认识的基础上，初步研究了PARP在白血病细胞中的异常活性，白血病细胞染色质结构异常及其可能的意义。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新