白血病

Objective To investigate the clinic effects of standard and improved FLAG regimen in treatment of refractory and relap sed acute myeloid leukemia.

目的研究标准和改良FALG方案治疗急性难治性髓系白血病的临床效果。方法选择中国医科大学附属一院血液科内科2005-06~2007-11间，收治的27例难治性AML患者。

Objective To study the relationship between reticulin myelofibrosis of bone marrow and acute leukemia cells with plastic embedding.

目的 应用经塑料包埋骨髓活组织切片技术研究骨髓网硬蛋白纤维与白血病细胞的消长关系。

Methods Before and after the treatment of 16 acute leukemia cases,Gomorri and Masson stainings were used to observe the change of reticulin myelofibrosis content of bone marrow.

采用Gomori染色和Masson三色染色检测16例急性白血病患者治疗前后骨髓网硬蛋白纤维含量变化。

Key words］ chronic Leukemia;myelofibrosis;reticulin fibre;m egakaryocyte.bone marrow biopsy

关键词］慢性白血病；骨髓纤维化；网硬蛋白纤维；巨核细胞；骨髓活组织检查

A ringlike structure, segment, or part.A retrovirus that causes AIDS. HIV was formerly known as HTLV-III.

人类免疫缺陷病毒一种引起爱滋病的反录酶病毒，它原先被认为是人体t细胞白血病毒三期

Our data are showed that apoptosis parameters including DNA fragmentation, nuclear morphological change and sub-G1 fraction, appeared after 24 h by 5 μM rottlerin treatment. Furthermore, rottlerin caused a decrease in 72% of ODC protein expression and an increase in threonine, rather than serine and tyrosine dephosphorylation on ODC enzyme compared with the control after incubation for 10 h. To determine whether ODC could down-regulate rottlerin-induced apoptosis, HL60 cells were stably transfected with ODC cDNA. HL60-ODC cells exhibited a 2.5-fold increase in ODC protein compared with vector only (HL60-pcDNA3) or HL60 cells.

在我们筛选天然化合物实验中，发现rottlerin抑制鸟胺酸去羧化活性最具成效，之前的研究人员已知蛋白激Cd调节鸟胺酸去羧化的活性，因此在人类白血病HL60细胞处理rottlerin的实验中发现加入rottlerin二十四小时后，细胞进行计划性死亡，并可侦测到DNA片段、细胞核浓缩及sub-G1提增；而细胞处理药物十小时后与控制组细胞比较，观察到鸟胺酸去羧化的蛋白表现与活性下降50﹪以上；除此以外，测定鸟胺酸去羧化去磷酸化的情况，发现於酥胺酸位置有显著差异，而丝胺酸和酪胺酸位置并无差异。

It was recently reported in Japan that effective component of the extract of Rubia Cordifolia L has obvious inhibition for leukemia, cancer of colon and carcinoma of the lung in mice, its curative effects equaled or exceeded to the catharanthine, mitomycin and adriacin and had less virulence for normal cells.

近来日本学者系川秀治等研究发现茜草提取物中的有效成分环己肽类化合物对小鼠的白血病、腹水癌、大肠癌、肺癌均有明显的抑制作用，其疗效等于或优于长春碱，丝裂霉素、阿霉素，并且对正常细胞的毒性低。

On human carcinoma cells.MethodsMorphological change observation and live cell accounting were used to investigate the inhibitory effects of Sanguisorba officinalis L.

方法细胞形态观察和活细胞计数法研究地榆水提液对人白血病细胞K562，肝癌细胞HepG2，胃癌细胞BGC823，宫颈癌细胞Hela生长的抑制作用。

FINDINGS: Somatically acquired JAK2 mutations were identified in 16 (18%) patients with Down's syndrome-associated acute lymphoblastic leukaemia.

结果：唐氏综合征相关的急性淋巴母细胞白血病患者中有16例（18％）鉴定出了获得性体细胞JAK2突变。

This method also helps to subclassify cell types, which may, in turn, help the physician to decide on the best treatment to apply in that type of leukemia or lymphoma.

种方法也能够帮助区分细胞亚型，可帮助内科医师制定最佳的治疗方案用于不同类型的白血病或淋巴瘤。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。