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白血病

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The median time from the diagnosis of RAEB to leukemia transformation , was 27 months in 7 cases with hypoplastic RAEB.

17例患者中7例自低增生RAEB转为急性白血病时间为1-74个月,中数为27个月。

Amplified cells were cultured in PGC culture medium and non-adherence culture flask till idiosome formed, adhered and differentiated.

体外分化采用无黏附特性的培养瓶和除去白血病抑制因子的原始生殖细胞培养液,以脱饲养层法悬浮培养扩增的细胞,直到拟胚体形成及贴壁分化。

At the fifth passage, two cell strains were made into cell suspension at l×10^9L^(-1). 0.5 mL was subcutaneously incubated at the inguina of each rat for 8 weeks. Amplified cells were cultured in PGC culture medium and non-adherence culture flask till idiosome formed, adhered and differeotiated.

体内实验取连续传5代的2个细胞株,分别制备浓度为l×10^9L^(-1)的细胞悬液,于每只小鼠两侧腹股沟处皮下各接种0.5 mL,培养8周体外分化采用无私附特性的培养瓶和除去白血病抑制因子的原始生殖细胞培养液,以脱饲养层法悬浮培养扩增的细胞,直到拟胚体形成及贴壁分化。

Objective: The first aim of this study was to investigate bcr-abl associated T cell receptorVαand Vβgene repertoire by analyzing the restricted usage and clonal expansion of TCRVαand Vβsubfamily T cells from the normal individual peripheral blood induced bybcr-abl peptideso The second aim was to construct the idiotype TCR Vα-PIRES-TCR Vβeukaryotic vector and investigate its expression in vitro. The data will be expected toprovided the methods in development of the leukemia antigen specific cytotoxic Tlymphocyte modified by the specific TCR.

目的:通过分析bcr-abl多肽诱导正常人T细胞克隆性增殖和TCR Vα和TCR Vβ基因选用情况,获得识别bcr-abl多肽的特异性TCR基因,并构建TCR Vα和TCR Vβ双基因表达载体及分析其体外转染细胞和表达特点,从而为研制TCR转基因获得白血病抗原特异T细胞的研究提供实验依据。

Indirubin has been used clinically to treat chronic granulocytic leukemia, but poor solubility limited its absorption in the body.

靛玉红用于临床治疗慢性粒细胞白血病已有多年',疗效明确,但溶解度差,影响在体内的吸收。

Intrathecal Medications Certain types of leukemia and lymphoma have a tendency to spread to the nervous system.

鞘内用药。确定类型的白血病和淋巴瘤有向神经系统播散的倾向。

Intrathecal Medications Certain types of leukemia and lymphoma have a tendency to spread to the nervous system.

鞘内用药。某些类型的白血病和淋巴瘤倾向于扩散到神经系统。

Patients were consideredpositive when the expression were more than 20% cutoff for ZAP-70 and30% cutoff for CD38 .The CDS+ T cells in the same sample were used asinternal positive control, Isotype control was use for every sample .serumβ2-microglobulin was analyzed by ratenephelometry.

应用四色流式细胞术检测50例B-CLL患者外周血白血病细胞ZAP-70和CD38的表达,以ZAP-70≥20%、CD38≥30%为阳性,以CD5~+的自身T细胞为内在阳性对照,同时作同型对照。

Results:LAK cell activity was lower in patients with leukemia than in normal individuals.

目的:了解钝顶螺旋藻多糖对正常人和白血病患者LAK细胞活性作用,探讨螺旋藻作用机理。

Except that HTLV-Ⅰ was related to leucemia,the relationship between it and rheumatism is a controversial question.

除了与白血病有关外,HTLV-Ⅰ与风湿病的关系仍是国内外颇具争议的研究热点。

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