白血病

To explore the expressions of the intercellular adhesion molecule3（ICAM3） in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的 探讨细胞间粘附分子3(intercellular adhesion molecule3，ICAM3)在急性白血病（acute leukemia，AL）中的表达及其在临床疗效、髓外浸润中的意义。

Objective To explore the expressions of the inter-cellular adhesion molecule-3 (ICAM-3) in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的 探讨细胞间粘附分子－3(inter-cellular adhesion molecule-3， ICAM-3)在急性白血病(acute leukemia， AL)中的表达及其在临床疗效、髓外浸润中的意义。

To explore the expressions of the intercellular adhesion molecule-3（ICAM-3） in acute leukemia and to investigate its role in clinical therapeutic efficacy and extramedullary infiltration.

目的探讨细胞间粘附分子-3(intercellular adhesion molecule-3，ICAM-3)在急性白血病（acute leukemia，AL）中的表达及其在临床疗效、髓外浸润中的意义。

Extramedullary infiltration was more common in hHCA＋ patients with AML than in hHCA－ patients.

至于急性髓性白血病预后有待进一步探讨。

Preliminary antitumor activity in vitro of the new compounds indicated that the compounds have obvious inhibitory effect on human leukaemia cell (HL-60) and human galactophore cancer cell (MDA-MB-468) in the concentration of 10-4 mol/L. This result is a basis for further study on the synthesis and biological activity of this kind of compounds.

对所合成的10个新化合物进行了抗肿瘤体外生物活性试验，初步生物活性实验结果表明，该类化合物在浓度为10-4 mol/L时对人白血病细胞株(HL-60)和人乳腺癌细胞株(MDA-MB-468)有明显的抑制作用，在浓度为10-5 mol/L时没有明显的抑制作用，这一研究结果为进一步研究此类化合物的合成、生物活性的研究奠定了基础。

The effects of gambogic acid on the growth of three leukemia cell lines were studied by MTT assay.

结果：(1)藤黄酸对HL-60、U937、K562三种白血病细胞系均具有明显的抑制增殖作用。

Study Group easy Zhengfang, he said, with gambogic acid inhibiting angiogenesis cancer the biggest advantage is that in theory it can inhibit the growth of any tumor, including leukemia caused the liquid tumor, it is not the traditional method of cancer match.

研究组的易正芳博士说，用藤黄酸抑制血管新生抗癌的最大优势是，它在理论上能抑制任何一种肿瘤的生长，包括引起白血病的液体肿瘤，这是传统抗癌方法所无法比拟的。

Part II Regulation of gambogic acid on anti-apoptotic protein of Jurkat cells and Raji cellsTo study the Regulation of gambogic acid on anti-apoptotic protein of Jurkat cells and Raji cells.

第二部分藤黄酸对淋系肿瘤细胞系的细胞凋亡及抗凋亡蛋白的调控作用研究藤黄酸对人急性T淋巴细胞白血病细胞株Jurkat细胞和人Burkitt淋巴瘤细胞株Raji细胞的诱导凋亡及抗凋亡蛋白的调控作用。

Both U937 and K562 cells were found arrested in G0/G1 phase when interfered by gambogic acid, while the percentage of cells in S phase was decreased accordingly.

此外，藤黄酸也不是对所有白血病细胞均有诱导周期阻滞作用，HL-60细胞可能在其发生周期阻滞前即已凋亡。

Part III Gambogic acid induces death inducer-obliterator 1-mediated apoptosisTo explore the apoptosis inducing effects of GA on Jurkat cells and Raji cells and its underlying mechanism.

第三部分藤黄酸对淋系肿瘤细胞系死亡诱导清理子的调控作用探讨藤黄酸对人急性T淋巴细胞白血病细胞株Jurkat细胞和人Burkitt淋巴瘤细胞株Raji细胞的抗癌作用的分子机理。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。