白血病

Skin manifestations of leukemia are varied and include leukemia cutis (direct cutaneous infiltration by leukemic cells), Sweet's syndrome, erythema multiforme, erythema nodosum, pyoderma gangrenosum, and bullous pemphigoid.

白血病的皮肤表现比较多样，包括皮肤白血病（白血病细胞直接渗入皮下）、斯威特氏综合征、多形性红斑、结节性红斑、坏疽性脓皮症以及大疱性类天疱疮。

Methods Compounds were isolated and purified by various column chromatographic techniques and their structures were elucidated on the basis of spectral analysis (IR, ESIMS, 1HNMR, 13CNMR). The inhibitory activity against the proliferation of HL60, REH and Raji cell lines was determined by using MTT assay.

用色谱方法分离栀子中化学成分，用波谱技术(IR，ESIMS，1HNMR，13CNMR)进行结构鉴定，用四唑盐比色法测定化合物对白血病细胞（HL60人早幼粒细胞白血病、REH人急性淋巴细胞白血病、 Raji淋巴瘤）增殖的影响。

Methods Real-time quantitative retroverse polymerase chain reaction method was used for detecting RbAp46 expression levels in BM cells of 140 patients with acute leukemia,13 with chronic myelogenous leukemia in chronic phase, 7 with CML in blast crisis and 32 with non-leukemic disorders.

方法建立实时定量RTPCR方法，利用SYBRGreenⅠ染料检测140例急性白血病、13例慢性粒细胞白血病慢性期和7例CML急变期患者以及32例非白血病患者骨髓细胞RbAp46基因的表达水平。

Our results indicate that 1 NSC606985, at nanomolar level, can effectively induce apoptosis in AML cells NB4 and U937 and significantly inhibit the proliferation without cell death in breakpoint cluster region–Abelson murine leukemia kinase-carrying leukemic K562 cells; 2 At such low concentrations, this agent also significantly inhibits the clonogenic activity of hematopoietic progenitors from patients with AML; 3 For apoptosis induction, NSC606985 rapidly induces the proteolytic activation of protein kinase Cδ with loss of mitochondrial transmembrane potential and caspase-3 activation; 4 Co-treatment with rottlerin, a PKCδ-specific inhibitor, completely blocks NSC606985-induced mitochondrial m loss and caspase-3 activation, while the

结果显示：(1)纳摩尔浓度的NSC606985即可有效诱导AML细胞系NB4和U937细胞凋亡并显著抑制含有bcr-abl融合蛋白激酶的K562细胞的增殖；(2)低浓度的NSC606985也显著抑制来自AML病人骨髓的新鲜白血病细胞的克隆形成能力；(3)除了迅速诱导线粒体跨膜电位的崩塌及Caspase-3的活化外，NSC60698也导致蛋白激酶Cδ的水解激活；(4)PKCδ特异的抑制剂rottlerin能够完全抑制NSC606985诱导的线粒体跨膜电位的崩塌和Caspase-3的活化，而Caspase-3特异的抑制剂z-DEVD-fmk仅能部分削弱PKCδ的活化及细胞的凋亡；(5)以移植PML-RARα转基因小鼠产生的白血病细胞建立的模型研究了该化合物对白血病可能的治疗作用。

A retrospective analysis of 42 cases of leukemia with t(8;21) translocation was undertaken by us.

为了解t（8；21）白血病的特征及在急性白血病分型中的地位，对42例t（8；21）白血病患者作了回顾性分析。

Inthis study, in order to investigate the function of tryptase on the mechanism of acuteleukemia, tryptase expressed by leukemic cells were determined in 61 patients withacute leukemias.

本实验检测了61例急性白血病患者白血病细胞类胰蛋白酶的表达情况，进一步探讨了类胰蛋白酶在急性白血病的发生发展中的作用。

TO Acute Leukemia, the level of IL-1 J3 ,IL-6 and TNF-a rise significant in the stage of Yingfen Syndrome, and significant higher than that of the Weifen and Qinfen stge, when it comes to IL-10, the level of its declines rapidly ,but the level of IFN-r changes a little.The serum level of IL-6 of Yingfen Syndrome of Acute Leukemia is higher than that of the unacute one.

急性白血病发展到营分证阶段时，IL一1日、IL一6、TNF--a 显著升高，高于卫分证、气分证，1L一10则显著下降，而IFN一y无显著变化；急性白血病营分证血清中工L一6的表达水平高于非急性白血病营分证，而工L一10则相反。

In AML,monocytic leukemia is easier to become into HAL than other leukemias. In ALL,T-lineage antigens of HAL group are more easily expressed than those of NHAL group; the leukemia cells of HAL group are naiver than those of NHAL group,meanwhile the prognosis of HAL is poor. http://www.44dx.com

HAL比NHAL骨髓受抑程度更重，AML中单核细胞性白血病发生高白细胞性白血病的可能性高，ALL中HAL比NHAL更易于表达T系抗原，HAL的白血病细胞较NHAL处于更早分化阶段，同时HAL预后不佳。

It is concluded that bone marrow inhibition of hal group is more severe than that of nhal group. in aml,monocytic leukemia is easier to become into hal than other leukemias. in all,t-lineage antigens of hal group are more easily expressed than those of nhal group; the leukemia cells of hal group are naiver than those of nhal group,meanwhile the prognosis of hal is poor.

hal比nhal骨髓受抑程度更重，aml中单核细胞性白血病发生高白细胞性白血病的可能性高，all中hal比nhal更易于表达t系抗原，hal的白血病细胞较nhal处于更早分化阶段，同时hal预后不佳。

Berbamine extracted from Chinese herb might be a promising candidate of new drug for clinical anticancer treatment, especially for bcr-abl〓 diseases.

我们认为，从中草药小檗属植物中提取的小檗胺在体外及体内均有显著的抗白血病作用，且抗瘤谱广，有望成为一种新型的广谱抗白血病药物，尤其在bcr/abl表达阳性白血病的治疗中发挥作用。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。