白血病

During these years (1997-2000) in the research area of annonaceous acetogenins 5 natural products and a number of chiral-pure analogs of annonaceous acetogenins have been synthesized using sugars as the starting materials. Their high activity and selectivity against cell line of colon tumor and a relationship between activity and configuration have been found too. In the respect of inhibitor of sialidase two new methodologies for the synthesis of chiral-pure 3-deoxy-ulosonic acid using hetero-Diels-Alder reaction or asymmetric propargylation as the key reaction were developed. On the topic of anti-leukemia marine natural product clavulactone a synthetic method based on the free radical cyclization and starting from sugar has been developed. In other title of PKC inhibited agent sphingosine a new synthetic route with SN2' as the key reaction has also been disclosed.

项目期间（1997-2000）在番荔枝内酯方面从糖出发合成了五个天然产物和一批手性纯的类似物，它们对肠癌细胞有很高的活性和选择性，并与构型有关；在唾液酸酶抑制剂方面发展了二类全新手性纯高碳糖的合成方法－杂原子D－A反应或丙炔基不对称加成为关键的反应；抗白血病海洋天然产物群柱虫内酯方面研究了由糖出发和自由基环化反应的合成方法；对PKC 起抑制作用的鞘氨醇方面也开创了新的合成途径－由糖出发并以SN2'反应为关键反应。

Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis.

这样的脾肿大通常预示有骨髓增生型疾病，例如慢性髓性白血病或骨髓纤维化。

Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis .

这样的脾肿大通常预示有骨髓增生型疾病，例如慢性髓性白血病或骨髓纤维化。你知道它的英文吗？

Every year in the United States, more than 30,000 people are stricken with leukemia and other fatal blood diseases.

在美国，每年有三万多人罹患白血病或其他血液方面的绝症。

MethodsThe tumor xenografts model was established by injecting the mouse lymphocytic leukemia cells (P388) in the subcutis of anterior axillary of Kunming mice, and then was treated with CZBG by intragastric administration and different doses of adriamycin by intraperitoneal injection.

方法将小鼠淋巴细胞白血病细胞系P388细胞接种于昆明小鼠腋前皮下构建小鼠移植瘤模型，予复方浙贝颗粒联合不同剂量的阿霉素治疗。

Objective:To study the changes of serum sIL-2R and T-lymphocyte subgroup in patients with leukemia.

目的：探讨白血病患者外周血T淋巴细胞亚群和可溶性白细胞介素-2受体(sIL-2R)的变化。

Treatment and outcomes depend on the type and subtype of leukemia.

治疗和结果取决于白血病的类型和亚型。

A patient's age, general health and subtype may play a role in determining the best treatment plan.

病人的年龄，健康状况，所患白血病亚型可在最佳治疗方案的确定中起作用。

Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.

在实验研究基础上，本研究进一步运用免疫沉淀和Western Blot印迹方法，检测AML患者原代细胞JAK2和STAT3活化情况，并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现，11例AML患者中，有3例呈现STAT3组成型活化（STAT3阳性，下同），无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性；在此3例患者中，1例未取得缓解，另外2例虽然取得短暂缓解，但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高，而凋亡率数值较低。

METHODS: A series of N-octyl-N'-succinyl chitosan labeled with fluorescein, were incubated with HepG2 liver cancer cells, K562 leukemia cells, A549 human lung cancer cells, and BGC cancer cells respectively and followed by using flow cytometry and enzyme-linked immunosorbent assay to assess the affinity and inhibition of N-octyl-N'-succinyl chitosan for the four kinds of tumor cells already mentioned.

用异硫氰酸荧光素对N-正辛基－N'-琥珀酰基壳聚糖进行标记，再分别与人肝癌细胞(HepG2)、人白血病细胞(K562)、人非小细胞肺癌细胞(A549)及人胃癌细胞共培养，通过流式细胞仪及酶联免疫检测仪测定N-正辛基－N'-琥珀酰基壳聚糖对肿瘤细胞的亲和性及抑制力。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。