白血病

In these diseases, there is an increase in DNA damage and a risk of progression to acute leukemia.

该病中DNA损伤和发展为急性白血病的风险增加。

It is reported that ABA can inhibit the proliferation of mice leukemia L5178Y cells.

有研究表明ABA能对鼠白血病L5178Y细胞增殖产生抑制作用。

Some leukemogenesis has been shown to be aberrance of epigenetic modification.

白血病的发生和发展与表观遗传修饰异常直接相关。

Objective To assess the clinical significance of detection of immunosuppressive acidic protein in patients with acute leukemia.

目的 探讨免疫抑制酸性蛋白测定在急性白血病病人中的临床意义。

Actinomycin D is the potent inhibitor of RNA synthesis, and is demonstrated to be able to induce Sf-9 cell, K562 cell, aleolar macroages cell CTLL-2 and Jurkat cell apoptosis.

放线菌素D是RNA合成抑制剂，具较强的诱导细胞凋亡的能力，实验证明放线菌素D可诱导Sf-9细胞，人白血病细胞株K562，肺泡巨噬细胞，CTLL-2和Jurkat细胞等凋亡。

Objective To investigate the expression of BP1 gene in patients with acute leukemia and its significance.

目的 探讨BP1基因在急性白血病患者中的表达及其临床意义。

Objective:To evaluate the role of telomerase activity in development of acute myeloid leukemia.

目的：探讨端粒酶活性在急性髓细胞白血病发生中的作用。

Meanwhile,HDAC1 acetylation level is significantly increased.The overexpression of HDAC1 can promote erythroid cell proliferation and inhibits induced differentiation,the knockdown of HDAC1 or 2 inhibits erythroid cell proliferation and promotes induced differentiation.We also found that HDAC1 affects GATA1 mediated transcription activity.Thus our data revealed that HDAC1 may negatively regulate GATA1 mediated transcription and suggest that the dynamic regulation of GATA1 associated NuRD/MeCP1/HDAC1/HDAC2 complex may determine the onset of erythroid differentiation programs.Moreover,this study will eventually help to design new therapeutic approaches in treatment of leukemia.

研究发现在被诱导分化的小鼠红细胞白血病细胞中与GATA1相结合的HDAC1被乙酰化并失去活性，在血细胞中过表达HDAC1能够促进血细胞的增殖并抑制分化，反之在血细胞中敲除HDAC1或HDAC2能抑制血红细胞的增殖并促进分化，而且HDAC1能够负调控GATA1的转录活性，GATA1与NuRD/MeCP1复合体之间的动态调控，决定血红细胞分化的发生和发展，并为探索白血病的致病机理奠定了理论基础。

The CALM and AF10 fusion transcripts are involved in the pathogenesis of haematological malignancies with t(10, 11), and is associated with a poor prognosis.

CALM—AF10与t(10；11)转换白血病的发生密切相关，且t(10；11)转换的白血病患者预后较差。

A total of 58 cases of de novo adult patients with AML M5 were investigated.

急性单核细胞白血病（AML-M5）是一类具有独特生物学和临床特征的急性髓细胞白血病。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。