白血病

Methods Sixty-six patients with hematological diseases （40 cases of acute leukemia, 24 chronic myeloid leukemia, and one each severe aplastie anemia and β-thalassemia） rceived bone marrow （ BMT, n = 48） or peripheral blood stem cell transplantation （ PBSCT, n = 18 ） from HLA-compatible unrelated donors after BUCY or TBI conditioning. Forty patients received longer and intensive GVHD prophylaxis （ cyclos- porin A from day - 10 combined with mycophenolate mofetil）.

方法慢性粒细胞白血病患者24例，急性白血病患者40例，其他血液病患者2例，经预处理治疗后，进行人类白细胞抗原基本相合的非血缘关系骨髓移植48例，外周血干细胞移植18例：部分患者采用长程加强的移植物抗宿主病的预防方案（将环孢菌素A提前至预处理开始时使用，同时加用霉酚酸酯）。

ES cells were maintained on gelatin-coated dishes in Iscove's modified Dulbecco medium containing 0.1 mmol/L of nonessential amino acids, 2 mmol/L of L-glutamine, 0.1 mmol/L of monothioglycerol, 15% fetal bovine serum, and 1000 U/mL leukemia inhibitory factor. Embryonic bodies were firstly formed by ES cells with hang drip method in IMDM without LIF. Six-day-old EBs were trypsinized and the cells were resuspended at a concentration of （3-4）×109 L-1 cells per 1 mL of a 1:1 mixture of culture medium and Matrigel?

实验方法：将鼠胚胎干细胞株接种于被覆明胶的培养瓶内，加入含0.1 mmol/L非必需氨基酸、2 mmol/L L-谷酰胺、0.1 mmol/L二羟基丙硫醇、15%胎牛血清、1 000 U/mL白血病抑制因子的IMDM培养液。3 d后采用&悬滴法&使细胞在不含白血病抑制因子的上述IMDM培养液中形成胚胎体，6 d后胰酶消化得到胚胎干细胞，浓度调整为（3~4）×109 L-1，与Matrigel？

Objective:Studies the East Asian pliers scorpion poisonous weakly to perish in vitro induction acute early young granule leukemia cell line HL-60 and to suppress its growth the function.

东亚钳蝎毒诱导白血病细胞HL-60凋亡的实验研究目的：研究东亚钳蝎毒在体外诱导急性早幼粒白血病细胞株HL-60凋亡并抑制其生长的作用。

However, as for the leukemia patient, the leukemia cells would damage the defense mechanism of urinary system through infiltration of leukemia cells, what's more, the RBC in haematuria is good nutrient for growth of bacteria, and thus the infection is quite easy to be caused.

但到病人患有白血病后，白血病细胞对泌尿系统的浸润会损害泌尿系的防卫机制。加之血尿中的红细胞是细菌生长的良好营养，故及易发生感染。

Chromosome analysis of metaphases from bone marrow cells or cul-tured peripheral blood lymphocytes of 15 patients with blood disorderswas carried out.

对15例血液病患者进行了骨髓或外周血培养细胞的染色体观察。15例中12例临床确诊为慢性粒细胞白血病，2例诊断为急性粒细胞白血病，1例为继发性红细胞增生症。

Many childhood leukemias result from mutations called translocations, where gene pieces on chromosomes accidentally relocate and misalign.

Ernst说：&MLL是造成一岁以下儿童白血病的最常见基因，而这种白血病利用现有癌症治疗手段的效果非常不好。&

Many childhood leukemias result from mutations called translocations, where gene pieces on chromosomes accidentally relocate and misalign. In infant leukemia, the chromosome containing the MLL gene breaks within MLL and ends up fused to a different gene.

很多儿童白血病是由一种被称为易位的基因突变（染色体上基因片断突然移位重排）引起的，在幼儿白血病中，含有MLL的染色体破损，然后融合到其它基因上。

To cooperate cure better, improve the life quality of patient of leukaemia of chronic bead cell, nurse commonly in executive internal medicine on groovy foundation, increase the standardization that suits patient of leukaemia of chronic bead cell to nurse content.

为了更好地配合治疗，提高慢性粒细胞白血病病人的生命质量，在执行内科一般护理常规的基础上，增加适合慢性粒细胞白血病病人的规范化护理内容。

The poor survival of AML patients raises expectations that LSC-targeted therapies might achieve durable remissions.

急性髓性白血病病人具有较低的生存率，因此，人们期望靶向白血病干细胞的治疗策略可以使AML得到缓解。

Furthermore, the abnormality of PARP's activity and chromatin structure in leukemia cells was detected. Possible significance of this result was discussed.

在此认识的基础上，初步研究了PARP在白血病细胞中的异常活性，白血病细胞染色质结构异常及其可能的意义。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。