白血病

Leukemia is the most common malignant diseases of hematological system.

白血病是血液系统最常见的恶性疾病，近年来白血病的发病率呈逐渐上升的趋势。

MDS might be diagnosed according to the pathosis hemogenesis.

有9例转化为白血病，1例转为急性淋巴细胞白血病。

In conclusion, acute leukemia has high heterogenicity, which could be defined as AML, but more like lymphocytic origination by morphological study. Immunophenotyping analysis could contribute to the final diagnosis of malignant cells.

急性髓系白血病细胞形态学可表现淋巴细胞样特点，结合免疫分型有助于进一步确定白血病细胞的类别分型。

To further investigate whether cyclin A played as a key molecular in cell proliferation, HL-60 cells were exposed to different concentrations of hexamethylene bisacetamide.

为了进一步研究cyclin A在白血病细胞增殖中的作用，用在体内、体外均有抗肿瘤作用的六亚甲基二乙酰胺在体外抑制白血病细胞系HL-60增殖，并诱导其分化。

To further investigate their roles in cell proliferation apoptosis and differentiation, three human leukemia cell lines (K562, U937 and HL60) exposed to various concentration of hexamethylene bisacetamide, a potent inducer of differentiation of transformed cells both in vivo and in vitro, were used as an in vitro model for the study of cell proliferation, differentiation and apoptosis.

为了进一步研究cyclin A和p21在白血病细胞增殖，分化，凋亡中的作用，我们用在体内，外均有抗肿瘤作用的药物六亚甲基二乙酰胺在体外抑制白血病细胞株K562，U937和HL60增殖，诱导其分化，成功地建立了与药物干预浓度呈剂量-效应关系的，具有不同增殖，分化，凋亡状况的实验细胞模型。

Objective: To investigate the situation of TCR Vβ gene repertoire and clonal expansion in peripheral blood T cells from patients with acute lymphoblastic leukemia and T cell strains, and analysis the expressive characters of TCR V β gene idiotype. To develop the anti-lymphoblastic leukemia TCR idiotypic DNA vaccine.

目的：了解淋巴细胞白血病及T细胞株的TCRVβ基因谱系及其克隆性增殖情况，分析TCR Vβ基因独特型表达的特点，并构建具有抗淋巴细胞白血病作用的TCR独特型DNA疫苗。

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Scott, 41-year-old, a former leucemia victim who hit headlines by taking part in several above-ground marathon races clad in a heavy diving suit has taken his charity quest that helps children suffering from leucemia to the bottom of Loch Ness, with hopes for an encounter with the lake's most famous denizen.

41岁的斯科特曾是一位白血病患者，他先后几次穿着厚重的潜水服参加了陆上马拉松赛，成为头条新闻。这次他为患白血病的儿童举行募捐活动——在尼斯湖下进行马拉松，并期待能与湖内最负盛名的居民——尼斯湖水怪相遇。

Avian leukosis virus subgroup J was first isolated in 1989 and identified as a new subgroup of avian leukosis virus.

J亚群禽白血病病毒是1989年被分离、鉴定出的一个新的禽白血病病毒亚群，与其它ALV亚群比较，该亚群病毒的一个显著特点是其env基因非常独特。

Avian leukosis virus Subgroup J is a retrovirus which infects meat-type chickens.

J亚群禽白血病病毒是90年代由英国鉴定出来的ALV新的亚群，主要引起肉鸡的骨髓瘤白血病。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。