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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析,并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography,FFA)、吲哚青绿血管造影(indocyanine green angiography,ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例,73.5%),双眼同时患病118例(80.8%);后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%);前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例,98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%);后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障;毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现;炎症活动期FFA典型表现为斑驳状高荧光,ICGA发现脉络膜血管扩张、通透性增高等改变;VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎,随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

A variety of gram release paper, Glassine paper, kraft paper, double-plastic single silicon paper, double silicon paper, various kinds of imported Release Paper; a variety of PET-off membrane, a single silicon membrane, double-silicon film, the original membrane and white film, black film, membrane switch-specific membrane; all kinds of tape, double-sided tape, Burkina tape, police-style tape, kraft paper tape, textured paper tape, fiber tape; I Division sales PET release film has a different g weight-off edge, and can provide customers from the type of force production.

各种克重离型纸、格拉辛纸、牛皮纸、双塑单硅纸、双硅纸、各种进口离型纸;各种PET离型膜、单硅膜、双硅膜、原膜、白片、黑膜、薄膜开关专用膜;各种胶带、双面胶、布基胶带、警式胶带、牛皮纸胶带、美纹纸胶带、纤维胶带;我司销售的PET离型膜有不同克重的离型力,并可按客户提供的离型力生产。

Shandong Easytouch match factory is designed for all major hotels, restaurants, restaurants, alcoholic drinks and tobacco enterprises, tourism, leisure and entertainment to provide a dedicated manufacturer of matches gifts, breeds all kinds of specifications models have a book-style,éstyle, triangle , rectangular, lipstick-type, such as dozens of products, the use of white card boxes noodles, glass card, plastic, sub-membrane, four-color offset printing, bronzing and other high-end printing technology.sticks of white phosphorus surface smooth, clean and safe.

山东同创火柴厂是专为各大宾馆、饭店、餐厅、烟酒企业、旅游业、休闲娱乐场所等提供专用礼品火柴的生产厂家,品种有各种规格型号的书式、抽拉式、三角形、长方型、口红型等几十种产品,盒面采用白卡、玻璃卡、塑膜、亚膜、四色胶印、烫金等高档印刷工艺。火柴梗枝洁白,磷面光滑、整洁、安全。

The females incubated at 33 , their ovarium has powerful cortex, the germinal epithlium produce oocyte, its medulla degenerate into ovarian cavity. During sexual differentiation, mitochondria and smooth endoplasmic reticulum in cells of ovary increase in quantity, they disintegrate after sexual differentiation. There are a lot of big grana in cells of ovary before sexual differentiation, in the course of sexual differentiation the quantity of the big grana decrease, while small grana increase and peakafter sexual differentiation. The males incubation at 26 , cortices of their testes degenerate into a thin albuginea. Medulla are formed by testicular cords in which scatter spermatogonium.

33℃下孵化的小龟卵巢皮质发达,由原始生殖细胞产生卵原细胞,髓质退化成为卵巢腔,分化时卵巢细胞的超微结构显示线粒体和内质网的数量大大增加,它们在分化结束后解体,分化前细胞内有较多的大颗粒,在分化中大颗粒减少,小颗粒增多,在分化后小颗粒达到最多。26℃下孵化的小龟精巢皮质退化成为一层薄的白膜,髓质有许多睾丸管构成,管腔内有散落排列的精原细胞。

Surface modification of albumin chitosan blended membranes have been reported by us, via immobilization of bioactive complexes or coupling biomolecules on liposome-modified membranes through carbodiimide functional moieties .

表面修饰白蛋白混纺壳聚糖膜已报道的时候,经固定化生物活性物或生物大分子耦合对脂质体膜修饰通过碳化功能材料。

The result of immobilization showed that hydrophile membranes were more advantageous than hydrophobe ones to act as immobilization carrier. Crosslinking organophosphorus hydrolase by glutaraldehyde on polyethersulfone membrane is a simple and practical immobilization method. An appropriate amount of bovine serum albumin and crosslinker is necessary to get a good result of immobilization. In the biodegradation of methyl-parathion through enzyme membrane reactor, the effect of immobilized enzyme amount, flow rate of peristaltic pump, pH of the feed, and the methyl-parathion concentration on biodegradation rate was studied. It was shown that the biodegradation rate increased with immobilized enzyme amount and substrate concentration. Biodegradation rate didn't increase when the folw rate of the peristaltic pump was larger than 7 ml/min.

然后,研究固定化酶降解甲基对硫磷,从不同材料的膜载体固定有机磷水解酶的比较中,发现亲水膜比疏水膜适合作固定化酶载体;在此基础上,将有机磷水解酶固定在聚醚砜微滤膜上,并制成酶膜生物反应器,用于降解甲基对硫磷;戊二醛化学交联法固定时,酶液与10%牛血清白蛋白溶液的比例在3:1~2:1,与交联剂的比例在7:2~7:4范围内,固定化效果较好,并发现牛血清白蛋白和膜载体有降低酶活损失的作用;将固定化的酶膜装于酶膜反应器降解甲基对硫磷,实验结果表明:反应器的降解速率与固定化酶量呈正比,也随底物浓度的增加而加快,当流速低时,降解速率随流速增大而加快,到7ml/min以上时,降解速率不随流速脑黾佣洌到獾淖畹团ǘ任?

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大,疗效确切的抗真菌药,如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等,该类药物主要抑制β-葡聚糖合成酶,体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性,又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在,故具有高效低毒的临床效果,是一极具前途的新型抗真菌药;以真菌细胞膜为靶点开发出Histatin类药物,虽然作用机制目前还不完全明了,但其作用不同于临床常用的多烯类和氮唑类,并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效,并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用;通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Stripping processes are: film metalto screen ink wash, and then rederm phenylate scrub it screen on both sides of the film by soaking in the plan, 5-10 minutes of inmnersion, the version of the film, in which case the available water flushing, version of the film offmy, silk screen with water and dry clean, they can again for coating seihan.

脱膜工艺步调是:脱膜时首先不兵丝网印版上的油墨冲刷肮脏,然后用脱膜剂涂擦丝网印版的两面或者浸泡在脱膜剂洋,不纬5-10分钟把握的浸泡,版膜发白,这时可用火冲刷,版膜不穿着后,用火不兵丝网冲刷肮脏并潮湿,不离可再次用于涂布制版。

Using centrifugal casting method, hollow fiber membrane is encapsulated into dialyzers, and prepared by the water, urea, Lysozyme and BSA simulated liquid form, which uses Lysozyme instead of β_2-MG, BSA instead of human serum albumin. In this paper, the simulation solution is used to evaluate dialysis performance of PES hollow fiber membrane dialyzers.

采用离心浇铸法将中空纤维膜封装成透析器,用溶菌酶代替β_2~-微球蛋白,用牛血清白蛋白代替人血清白蛋白,制备由纯水、尿素、溶菌酶和牛血清白蛋白构成的模拟液,用此模拟液来代替患者血液,对本文研制的聚醚砜中空纤维膜透析器的透析性能进行评价。

Electrochemical properties, photoluminescence and electroluminescence properties of a series of copolymer with different content are studied detailedly. The results indicated there is strong energy transfer between blue- and green-yellow light emission units, so only single blue- or green-yellow emission peak appears in the PL and EL spectra and white light-emission cannot get.

对一系列不同含量的绿-黄光链段共聚物的电化学性能、光致发光和电致发光性能进行了研究,发现蓝光链段与绿-黄光链段间由于存在强的能量转移,导致共聚物膜的光致发光和电致发光光谱只出现单一的蓝-绿光或绿-黄光,而不能复合出白光。

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