白细胞的

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，"PMN-EC"相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，虽具有相对高的致白细胞和血小板下降的骨髓毒性，但毒副作用可耐受，已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物，但是作为一线用药仍然需要更多的临床证据来证实。

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，&PMN-EC&相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Reduce the hoist of leucocytes of sinus coronaries blood of myocardial ischemia and reperfusion injury dogs;2. decrease the leakage of plasma CK, CK-MB and LDH;3. regulate the vaso-active substances such as ET, TXB〓 and PGI〓;4. decreased the inflammatory cell factors such as IL-1, IL-6 and TNF

综上，奥沙恩注射液可降低心肌缺血再灌注损伤模型犬冠状窦血白细胞总数，减少I／R后CK、CK-MB和LDH的释放，调节血管活性物质ET、〓和〓的产生，降低血清炎性细胞因子TNF-α、IL-1和IL-6的含量，抑制PMN的激活及对心肌的浸润，减轻心肌组织的病理改变，以及减轻心肌缺血及坏死程度、降低心肌耗氧量，从而显示出较强的对犬急性心肌缺血再灌注损伤的保护作用。

We are sad cried, arrived in the evening, effort was done not have on my daughter body, send all over soft, be troubled by all the time, it is such pasts this day night the following day, I still have my Mom to holding the child in the arms to build a car directly with my wife went to city haemal institute, be in when us second when making detailed inspection to the daughter, the leucocyte that discovers a daughter is as high as 610 thousand, red blood cell has 30 thousand only much, the doctor says, your child is too small, if cure, the likelihood can have life risk at any time, if not cure, your child still can live a few days more, hear this news I am about to break down simply, my tear flowed, passed a little while, we let a doctor help us look for bed, let daughter be in hospital, the doctor says, miss your child this circumstance, you are spent namely 100 thousand 200 thousand 1 million, when your child is being treated, life is potential a few minutes of lives were done not have, your child is held in the arms do not answer Hubei, you spend the money in how, also be person money two sky, the doctor says: Do you have remedial money?

我们都伤心哭了，到了晚上，我女儿身上没了力气，浑身发软，一直闹，这天晚上算是这样过去了第二天，我跟我老婆还有我妈抱着孩子直接搭车去了市血液研究所，当我们在次给女儿做详细检查的时候，发现女儿的白细胞高达61万之多，红细胞只有3万多，医生说，你的孩子太小，如果医治，可能随时都会有生命危险，如果不医治，你的孩子还可以多活几天，听到这个消息我简直快要崩溃了，我的眼泪哗啦的就流了下来，过了一会，我们让医生帮我们找床位，让女儿住院，医生说，想你们孩子这个情况，你就是花10万20万100万，你的孩子在治疗的时候，生命可能几分钟命就没了，你们的孩子就抱不回湖北了，你们花在多的钱，也是人财两空，医生说：你们有治疗的钱吗？

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。