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To observe pharmacological effects of Zangqingguo Houpian on antibacterial effect in vitro,2,4-dinitrophenol induced fever in rats,the croton oil induced swelling in mouse's ear and carrageen induced WBC movement in rat chest,rat granuloma induced by tampon,acetic-acid-induced twisting test in mouse and prednisolone acetate caused immunosuppressive mice.

采用体外抗菌、对2,4-二硝基苯酚所致大鼠发热、巴豆油所致小鼠耳肿胀及角叉菜胶致大鼠胸腔白细胞游走、棉球致大鼠肉芽组织增生、冰醋酸致小鼠疼痛、醋酸泼尼松龙致免疫低下等模型,观察藏青果喉片的药效学作用。

Methods (1) The influence on the rats with non-bacterial prostatitis of 1.5% carrageenin. Rats were divided randomly into the normal control group, the model control group, the Qianliean low-dose group (1.5 g/kg), mid-dose group (3.0 g/kg), high-dose group (6.0 g/kg), with 10 rats in each group. All groups were treated continuously for 7 days, once a day. The model control group was given distilled water, 30mins after the last medication, injects 1.5% carrageenin 0.05ml in each rat's prostate, after 24hs, behead execute the rats and record the white blood cell number and Lecithin density.(2) the influence on the swelling ears of rats.

方法(1)对1.5%角叉菜胶致大鼠非细菌性前列腺炎的影响:将大鼠随机分为正常对照组、模型对照组、前列安颗粒小剂量组(1.5 g/kg)、前列安颗粒中剂量组(3.0 g/kg)、前列安颗粒大剂量组(6.0 g/kg)及阳性药前列舒乐颗粒组(2.4 g/kg)6组,每组10只,各给药组大鼠连续灌胃给药7日,每日1次,模型对照组给予等容量蒸馏水,末次给药后30 min,在每鼠前列腺内注入1.5%角叉菜胶0.05 mL,24 h后断头处死大鼠,取致炎前列腺组织,镜下记录白细胞数和卵磷脂小体密度。

Objective To conduct Pharmacodynamics research of Qianliean pellet and provide the basis for the clinical medication. Methods (1) The influence on the rats with non-bacterial prostatitis of 1.5% carrageenin. Rats were divided randomly into the normal control group, the model control group, the Qianliean low-dose group (1.5 g/kg), mid-dose group (3.0 g/kg), high-dose group (6.0 g/kg), with 10 rats in each group. All groups were treated continuously for 7 days, once a day. The model control group was given distilled water, 30mins after the last medication, injects 1.5% carrageenin 0.05ml in each rat's prostate, after 24hs, behead execute the rats and record the white blood cell number and Lecithin density.

方法(1)对1.5%角叉菜胶致大鼠非细菌性前列腺炎的影响:将大鼠随机分为正常对照组、模型对照组、前列安颗粒小剂量组(1.5 g/kg)、前列安颗粒中剂量组(3.0 g/kg)、前列安颗粒大剂量组(6.0 g/kg)及阳性药前列舒乐颗粒组(2.4 g/kg)6组,每组10只,各给药组大鼠连续灌胃给药7日,每日1次,模型对照组给予等容量蒸馏水,末次给药后30 min,在每鼠前列腺内注入1.5%角叉菜胶0.05 mL,24 h后断头处死大鼠,取致炎前列腺组织,镜下记录白细胞数和卵磷脂小体密度。

Leukocytes, blood, and mucus may be present in the stool, depending on the causative agent.

大便可能含白细胞、血和粘液,这要视引起腹泻的原因而定。

Objective To establish leucopenia mouse model induced by chemotherapeutics and provide scientific basis for evaluation of CELLAID enhancing the effect of WBC on animal models.

目的 建立化疗药物使白细胞减少的动物模型,为富氧矿素提高实验动物WBC作用的评价方法提供科学依据。

The rise of CINC was an effect of activiting WBC after the ischemia or ischemia reperfusion and indicated that the change was involving in the damage of ischemia reperfusion.

实验性脑缺血再灌注外周血CINC有表达增高改变,其作用过程可能与白细胞激活过程有关,提示CINC增高可能在脑缺血再灌注损伤中起一定作用。

The changes of MDA in the plasma, CINC/IL-8 and NO in the serum, MPO in the skeletal muscle were studied at the end of ischemia and 1h, 2h, 4h, 8h, 12h during reperfusion.

分别于缺血4h末,再灌注1、2、4、8、12h,测定各组血浆中的MDA、骨骼肌组织中的MPO,血清嗜中性粒细胞化学趋化因子(CINC/IL-8),血清一氧化氮,用流式细胞仪及免疫组化法观察各组白细胞上粘附分子CD11b/CD18和骨骼肌血管中ICAM-1的表达情况及各组的组织学改变。

EGCG was reported to inhibit leukocyte migration in response to chemokines such as IL-8, CINC and MIP-2, to trap reactive oxygen species, to inhibit neutrophil degranulation and inhibit inflammatory mediator release.

EGCG的抗炎作用涉及多个环节,包括抑制趋化因子如白介素-8(IL-8、细胞因子诱导的中性粒细胞趋化因子-1(CINC-1)、巨噬细胞炎性蛋白-2(MIP-2)等诱导的白细胞的定向迁移、清除氧自由基、抑制嗜中性粒细胞脱颗粒及炎性介质的释放等。

The result of divide into groups comparison make clear the Troche of bearing blood have clearcut effect on the number decrease of leucocyte after radiotherapy,to comparise with model groupsp

通过分组比较结果表明生血片对肿瘤放疗后白细胞数减少有明确的治疗作用,与模型组比较(P<0.05),对骨髓有核细胞的检测表明生血片确有保护骨髓的作用。

MLL fusion genes likely co-opt normal MLL functions in blood cells, leading to the overproduction of white cells and leukemia.

融合后的基因含有正常MLL功能,这会导致白细胞过度增生,最终形成白血病。

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