白细胞

Objective To appraise the factors relevant to agranulocytosis induced by antithyroid drugs, the methods of treatment and the importance of monitoring.

目的 探讨抗甲状腺药物引起粒细胞缺乏症的影响因素、治疗措施及周围血白细胞计数监测的重要性。

Although the list of available and effective agents appears to be extensive, several are contraindicated in pregnant women, and long-term use of antibiotics to target inflammation has been linked to agranulocytosis and Stevens-Johnson syndrome.

尽管可用且有效的药物有很多，但是很多药物对怀孕女性会造成不良反应，而且长期针对炎症服用抗菌素容易导致粒性白细胞缺乏症和Stevens-Johnson综合症。

Recurring oral infections may indicate diabetes mellitus, agranulocytosis, neutropenia, leukemia, immunoglobulin defects, or disorders of leukocyte function.

反复出现的口腔感染，可能存在糖尿病，粒细胞缺乏症，中性粒细胞减少症，白血病，免疫球蛋白缺乏病或白细胞功能紊乱。

Recurring oral infectio may indicate diabetes mellitus, agranulocytosis, neutropenia, leukemia, immunoglobulin defects, or disorders of leukocyte function.

反复出现的口腔感染，可能存在糖尿病，粒细胞缺乏症，中性粒细胞减少症，白血病，免疫球蛋白缺乏病或白细胞功能紊乱。

In the diease,the GD itself and Antithyroid drug all can cause leukopenia,even agranulocytosis which can cause the infection ,septicemia,shock,e-ven thyroid storm .

在疾病过程中，GD本身和应用抗甲状腺药物均可引起白细胞减少，甚至粒细胞缺乏，易引起感染、败血症、休克，甚至甲亢危象，影响患者的预后。

It also is related to bone marrow structural damage resulting from tumor invasion,large proliferation of granulation or fibrous tissue,which often affect hemopoiesis.Leukemoid reaction occurred in the majority of malignancies is myeloid leukemia response,among which some are.neutropenia,and even agranulocytosis and increasion or decreasion of platelets.These are all have close relationship with marrow invasion of malignant tumor,immune reaction of the body and chemotherapy as well as radiotherapy.

亦与骨髓被恶性肿瘤细胞浸润、肉芽和纤维组织大量增生，使骨髓结构破坏，影响红系造血有关；绝大多数恶性肿瘤并发的类白血病反应是粒细胞性的，部分患者白细胞减少，甚至粒细胞缺乏，以及血小板增高或减少，均与恶性肿瘤细胞骨髓浸润、机体的免疫反应、放化疗有关。

Ping chuan-fang prescription is carefully composed accordingly. The clinical investigation shows that PCHF can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously improve the pulmonary function of the patient. The animal experiment showed that PCHF can prolong the asthmatic time and low the concentration of WBC, EOS, IL-4, ET-1 in the blood and BALF. It can restrain the collection of EOS in the lung and relieve the inflammation caused by EOS. It also can cut down the secretion of the respiratory air-way and relieve the obstruction of it.

动物实验表明：平喘方能明显延长卵蛋白造模大鼠的引喘潜伏期，且与氨茶碱对照有非常显著性差异(P＜0.01)；能降低哮喘模型大鼠血浆及肺泡灌洗液中白细胞、嗜酸性粒细胞及IL-4、ET-1的含量；能抑制肺局部EOS的聚集，明显减轻由EOS浸润引起的慢性变应性炎症反应；能减少气道分泌物，减轻细支气管及小血管管壁的增厚，减轻周围组织的水肿，从而减轻气道的阻塞，最终改善肺通气，缓解喘息症状。

Ping chuan-fang prescription is carefully composed accordingly. The clinical investigation shows that PCHF can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviouslycan not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously improve the pulmonary function of the patient. The animal experiment showed that PCHF can prolong the asthmatic time and low the concentration of WBC, EOS, IL-4, ET-1 in the blood and BALF. It can restrain the collection of EOS in the lung and relieve the inflammation caused by EOS. It also can cut down the secretion of the respiratory air-way and relieve the obstruction of it.

动物实验表明：平喘方能明显延长卵蛋白造模大鼠的引喘潜伏期，且与氨茶碱对照有非常显著性差异(P＜0.01)；能降低哮喘模型大鼠血浆及肺泡灌洗液中白细胞、嗜酸性粒细胞及IL-4、ET-1的含量；能抑制肺局部EOS的聚集，明显减轻由EOS浸润引起的慢性变应性炎症反应；能减少气道分泌物，减轻细支气管及小血管管壁的增厚，减轻周围组织的水肿，从而减轻气道的阻塞，最终改善肺通气，缓解喘息症状。

The antibodies in plasma were also detected by indirect antiglobulin test. The result showed that levels of WBC,TB,DB,Glu and reticulocyte in six patients treated with β-lactam antibiotics were raised remarkably. DAT was strongly positive,but no RBC antibodies were detected in the plasma by IAT. The binding of red cells by monocytes or lymphocytes was great,and the hemolysis of red cells by alexin not appeared. After stopping above-mentioned β-lactam antibiotic administration,patient's WBC,TB,DB,and Glu levels returned to normal values.

结果发现：6例患者的临床治疗的药物都属于β内酰胺类；住院期间患者的WBC、TB、DB、Glu的检测结果出现异常，红细胞的DAT试验结果均为阳性，IAT试验结果均为阴性；将DAT阳性的红细胞进行补体结合实验时，结果为阴性；细胞涂片见部分红细胞表面有颗粒状物质附着，细胞培养见部分红细胞被白细胞识别、黏附；改用其它抗生素后，患者的上述化验指标恢复到正常值范围内，DAT试验结果转为阴性。

The result showed that levels of WBC,TB,DB,Glu and reticulocyte in six patients treated with β-lactam antibiotics were raised remarkably. DAT was strongly positive,but no RBC antibodies were detected in the plasma by IAT. The binding of red cells by monocytes or lymphocytes was great,and the hemolysis of red cells by alexin not appeared. After stopping above-mentioned β-lactam antibiotic administration,patient's WBC,TB,DB,and Glu levels returned to normal values.

结果发现：6例患者的临床治疗的药物都属于β内酰胺类；住院期间患者的WBC、TB、DB、Glu的检测结果出现异常，红细胞的DAT试验结果均为阳性，IAT试验结果均为阴性；将DAT阳性的红细胞进行补体结合实验时，结果为阴性；细胞涂片见部分红细胞表面有颗粒状物质附着，细胞培养见部分红细胞被白细胞识别、黏附；改用其它抗生素后，患者的上述化验指标恢复到正常值范围内，DAT试验结果转为阴性。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。