白桦脂醇

Results Seven known compounds: ocotillol (1), ursolic acid (2), betulin (3), lupeol (4), 1β-hydroxy-lupeol (5),β-sitosterol (6) and sitosterol-4-en-3-one (7) were isolated.

结果 分离得到7个化合物，分别鉴定为：20S，24R-环氧达玛烷－3β，25-二醇(ocotillol， 1)、熊果酸(2)、白桦脂醇(3)、羽扇豆醇(4)、1β-羟基羽扇豆醇(5)、β-谷甾醇(6)、谷甾－4-烯－3-酮(7)。

Objective To investigate the effects and mechanism of betulin on rats with alcoholic liver disease.

目的：观察白桦脂醇对大鼠酒精性肝损伤的保护作用及其机制。

Objective To study the antioxidant effects of betulin on alcoholic liver disease in rats.

目的 观察白桦脂醇对大鼠酒精性肝损伤的抗氧化作用。

It is significant to study the pharmaceutical activities of betulin ,betulinic acid andtheir derivatives and to confirm the relationship between th...

研究白桦脂醇、白桦脂酸及其衍生物的药理活性，确定结构与活性间的关系，对筛选出更为经济、有效的药物成分具有重要意义。

They are obtained from avariety of botanical sources and betulinic acid can be easily prepared from the more plentifulprecursor betulin in a simple two-step process.

它们可以从丰富的植物资源中获得，白桦脂酸也可由更丰富的前体白桦脂醇经简单的两步制得。

Betulin has obviously protective effects on alcoholic liver injury in rats.The mechanism may be the induced decrease of lipid peroxide.

白桦脂醇能抑制酒精诱导脂质过氧化反应对肝组织的损伤，对酒精性肝损伤有明显的保护作用。

Methods Rats were randomly divided into six groups: normal group,alcoholic liver disease model group,betulin low-dose group,betulin middle-dose group,betulin high-dose group and positive control group.

将SD大鼠随机分为6组，正常组和酒精性肝病模型组、白桦脂醇低、中、高剂量组和阳性药物对照组。

The hepatic injuries of rats in the highdose betulin group were recovered obviously.

高剂量白桦脂醇还能明显改善由酒精引起的肝组织脂肪样变和坏死。

Betulin,betulinic acid and many of theirderivatives exhibit great promise as bioactive agents for the treatment of HIV infection andcancer.

白桦脂醇、白桦脂酸及其衍生物作为生物制剂在 HIV 和癌症治疗方面表现出了巨大的潜能。

High-dose of betulin has obviously protective effects on alcoholic liver injury in rats,the mechanisms probably contribute to reducing lipid peroxide and reducing fatty sediment in liver.

高剂量白桦脂醇对酒精性肝损伤有明显的保护作用，其作用机制可能为抗氧化、清除自由基代谢产物，抑制脂质过氧化反应；调节血脂、减少脂肪在肝脏的沉积。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。