癫痫

Vagus nerve stimulation is used to treat pharmacotherapy-resistant epilepsy and depression.

迷走神经刺激用于治疗药物治疗无效的癫痫和抑郁症。

OBJECTIVE: To observe the characteristics of epileptiform activities of rat hippocampal CA1 pyramidal neurons induced by low-dosage veratridine and investigate its possible ion mechanism.

目的：观察小剂量藜芦碱诱发大鼠脑海马CA1区锥体神经元产生癫痫样活动的特征，探讨其可能的离子机制。

The effects of phenytoin (2.5, 5, 10 and l5 μmol/L) and gabapentin (2.5, 5 and l0μ mol/L) on the epileptiform activity were observed under the volt age- clamp configuration. and the current changes for 1 hour in CA I neurons was also observed. Results Nine-sixteen minutes after veratridine perfusion, the huge.

分别在电压钳模式下观察2.5、5、10、15μmol/L苯妥英和2.5、5、10μmol/L加巴喷丁对这种癫痫活动的影响；测定藜芦碱灌流后CA1锥体神经元Ih电流的变化规律。

Low-dosage veratridine may induce runs of PDS like epileptiform activities on rat CA1 pyramidal neurons.

小剂量藜芦碱可在大鼠脑海马CA1区锥体神经元上诱发出阵发性去极化漂移样癫痫活动。

Recertly, the intrinsic nature of PDS has received more attention.OBJECTIVE: To observe the characteristics of epileptiform activities of rat hippocampal CA1 pyramidal neurons induced by low-dosage veratridine and investigate its possible ion mechanism.

近年来，阵发性去极化漂移的内因机制得到进一步关注和重视。；目的：观察小剂量藜芦碱诱发大鼠脑海马CA1区锥体神经元产生癫痫样活动的特征，探讨其可能的离子机制。

RESULTS: After perfusion of 0.5 μmol/L veratridine, the rat pyramidal neurons in CA1 area displayed relatively fixed-mode of runs of PDS bursting, followed by the hyperpolarization of cell membrane.

小剂量藜芦碱可在大鼠脑海马CA1区锥体神经元上诱发出阵发性去极化漂移样癫痫活动。

Methods By means of whole-cell patch clamp technique, the epileptiform discharge model of rats hippocampal CA1 neurons was constructed with extracellular perfusion of 0.5 μmol/L veratridine, and the model should be regarded as successfully estabilshed if bursting discharge emerged within 30 min perfusion.

通过膜片钳全细胞记录技术，胞外灌流0.5μmol/L藜芦碱，制作大鼠海马CA1锥体神经元癫痫样放电模型，如果在灌流30min内出现振荡样放电，即认为造模成功。

Objective To observe the effects of low dose of veratrine on the discharges of rat hippocampus pyramidal neurons, and to elucidate its possible cytological mechanism.

目的 观察小剂量藜芦碱对大鼠海马CA1锥体神经元放电的影响，并对其诱发产生癫痫样放电的离子机制进行初步探讨。

Results After a perfusion with low dose of veratrine, the pyramidal neurons were found to discharge relatively fixed-mode slow wave epileptoid bursts accompanied with hyperpolarization of membrane potential.

结果 小剂量Ver灌流后随着膜电位的超极化，大鼠CA1锥体神经元产生模式相对固定的慢波样癫痫样活动。

Inducing slow wave epileptoid bursts, the low dose of veratrine can remarkably change the discharge features of CA1 pyramidal neurons.

小剂量Ver可明显改变大鼠海马CA1锥体神经元的放电模式，诱发慢波样癫痫电活动。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。